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GSK-J2 - ≥99%, high purity , CAS No.1394854-52-4

COA

Grade & Purity:

≥99%

Cas Number: 1394854-52-4
Molecular Weight: 389.4
PubChem CID: 73010924
PubChem SID: 504772310

In stock

Item Number

G275564

Grouped product items
SKU	Size	Availability	Price
G275564-5mg	5mg	3	$73.90
G275564-10mg	10mg	3	$121.90
G275564-25mg	25mg	3	$274.90
G275564-50mg	50mg	6	$444.90
G275564-100mg	100mg	6	$741.90

Inactive control for GSK-J1

View related series

Histone Modification (1379)

Basic Description

Synonyms	3-[[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-4-pyrimidinyl]amino]propanoic acid \| BCP08263 \| SCHEMBL15937902 \| CHEBI:131154 \| GSK-J2 \| F85052 \| EX-A7232 \| GSK J2 \| 3-[[2-pyridin-3-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]a
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Inactive control for GSK-J1 (IC 50 > 100 µM for inhibition of JMJD3) in vitro . Pyridine isoform of GSK-J1.
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Product description GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Diazines
    - Subclass Pyrimidines and pyrimidine derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Diazines
Subclass	Pyrimidines and pyrimidine derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Pyridinylpyrimidines
Alternative Parents	Benzazepines Beta amino acids and derivatives Dialkylarylamines Secondary alkylarylamines Azepines Aminopyrimidines and derivatives Imidolactams Pyridines and derivatives Benzenoids Heteroaromatic compounds Amino acids Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds Organopnictogen compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Pyridinylpyrimidine - Benzazepine - Beta amino acid or derivatives - Dialkylarylamine - Aminopyrimidine - Azepine - Secondary aliphatic/aromatic amine - Pyridine - Benzenoid - Imidolactam - Heteroaromatic compound - Amino acid or derivatives - Amino acid - Secondary amine - Azacycle - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Amine - Organonitrogen compound - Organooxygen compound - Carbonyl group - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as pyridinylpyrimidines. These are compounds containing a pyridinylpyrimidine skeleton, which consists of a pyridine linked (not fused) to a pyrimidine by a bond.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504772310
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504772310
IUPAC Name	3-[[2-pyridin-3-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid
INCHI	InChI=1S/C22H23N5O2/c28-21(29)7-11-24-19-14-20(26-22(25-19)18-6-3-10-23-15-18)27-12-8-16-4-1-2-5-17(16)9-13-27/h1-6,10,14-15H,7-9,11-13H2,(H,28,29)(H,24,25,26)
InChIKey	LJIFOCRGDDQFJF-UHFFFAOYSA-N
Smiles	C1CN(CCC2=CC=CC=C21)C3=NC(=NC(=C3)NCCC(=O)O)C4=CN=CC=C4
Isomeric SMILES	C1CN(CCC2=CC=CC=C21)C3=NC(=NC(=C3)NCCC(=O)O)C4=CN=CC=C4
Molecular Weight	389.4
Reaxy-Rn	28168691
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=28168691&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
F2302404	Certificate of Analysis	Jun 11, 2024	G275564
F2302403	Certificate of Analysis	Jun 11, 2024	G275564
F2303287	Certificate of Analysis	Jun 11, 2024	G275564
F2303275	Certificate of Analysis	May 09, 2024	G275564
F2302406	Certificate of Analysis	May 09, 2024	G275564
F2302407	Certificate of Analysis	Mar 22, 2024	G275564
F2303302	Certificate of Analysis	Mar 22, 2024	G275564
F2303770	Certificate of Analysis	Mar 22, 2024	G275564
F2302401	Certificate of Analysis	Mar 22, 2024	G275564
F2302402	Certificate of Analysis	Mar 22, 2024	G275564

Chemical and Physical Properties

Solubility	Soluble in DMSO to 100 mM
Molecular Weight	389.400 g/mol
XLogP3	3.600
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	389.185 Da
Monoisotopic Mass	389.185 Da
Topological Polar Surface Area	91.200 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	517.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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