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GSK 591 dihydrochloride - ≥97%(HPLC), high purity , CAS No.2320953-89-5

COA

Grade & Purity:

≥97%(HPLC)

Cas Number: 2320953-89-5
Molecular Weight: 453.41
PubChem CID: 124201849
PubChem SID: 504773001

In stock

Item Number

G286872

Grouped product items
SKU	Size	Availability	Price
G286872-5mg	5mg	6	$193.90
G286872-10mg	10mg	5	$298.90
G286872-25mg	25mg	3	$671.90
G286872-50mg	50mg	3	$1,208.90

Potent and selective PRMT5 inhibitor

View related series

Histone Modification (1379)

Basic Description

Synonyms	EPZ015866, GSK 3203591 \| 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydropropyl]-4-pyridinecarboxamide dihydrochloride
Specifications & Purity	≥97%(HPLC)
Biochemical and Physiological Mechanisms	Strong and selective PRMT5 inhibitor (IC50=4 nM). The selectivity to PRMT5 is higher than other PRMTs and lysine methyltransferases. It can inhibit the proliferation of mantle cell lymphoma (MCL) in vitro.
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

Pubchem Sid	504773001
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504773001
IUPAC Name	2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyridine-4-carboxamide;dihydrochloride
INCHI	InChI=1S/C22H28N4O2.2ClH/c27-20(15-26-11-9-16-4-1-2-5-18(16)14-26)13-24-22(28)17-8-10-23-21(12-17)25-19-6-3-7-19;;/h1-2,4-5,8,10,12,19-20,27H,3,6-7,9,11,13-15H2,(H,23,25)(H,24,28);2*1H/t20-;;/m0../s1
InChIKey	CDKUMVXFXBTOBE-FJSYBICCSA-N
Smiles	C1CC(C1)NC2=NC=CC(=C2)C(=O)NCC(CN3CCC4=CC=CC=C4C3)O.Cl.Cl
PubChem CID	124201849
Molecular Weight	453.41

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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8 results found

Lot Number	Certificate Type	Date	Item
F2302435	Certificate of Analysis	May 04, 2023	G286872
F2302431	Certificate of Analysis	May 04, 2023	G286872
F2302429	Certificate of Analysis	May 04, 2023	G286872
F2302428	Certificate of Analysis	May 04, 2023	G286872
F2302430	Certificate of Analysis	May 04, 2023	G286872
F2302424	Certificate of Analysis	May 04, 2023	G286872
F2302423	Certificate of Analysis	May 04, 2023	G286872
F2302426	Certificate of Analysis	May 04, 2023	G286872

Chemical and Physical Properties

Solubility	Solvent:water, Max Conc. mg/mL: 45.34, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 45.34, Max Conc. mM: 100
Sensitivity	Moisture sensitive

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