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GSK 2837808A - ≥98%(HPLC), high purity , CAS No.1445879-21-9

COA COA
    Grade & Purity:
  • ≥98%(HPLC)
In stock
Item Number
G288241
Grouped product items
SKU Size
Availability
 Price Qty
G288241-5mg
5mg
3
$147.90
G288241-10mg
10mg
2
$246.90
G288241-25mg
25mg
1
$543.90
G288241-50mg
50mg
1
$979.90
G288241-100mg
100mg
1
$1,731.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Potent and selective LDHA inhibitor

View related series
Glucose Metabolism (1943) Lactate Dehydrogenase (31) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms 3-[[3-[(Cyclopropylamino)sulfonyl]-7-(2,4-dimethoxy-5-pyrimidinyl)-4-quinolinyl]amino]-5-(3,5-difluorophenoxy)benzoic acid
Specifications & Purity ≥98%(HPLC)
Biochemical and Physiological Mechanisms Potent and selective lactate dehydrogenase A and B (LDHA and LDHB) inhibitor (IC50values are 2.6 and 43 nM for LDHA and LDHB respectively). Inhibits lactate production in selected cancer cell lines. Reduces glucose uptake and enhances mitochondrial oxygen
Storage Temp Protected from light,Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Product description

GSK2837808A is a potent and selective lactate dehydrogenase A (LDHA) inhibitor with IC50s of 2.6 and 43 nM for hLDHA and hLDHB, respectively.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Quinolines and derivatives
Subclass Quinoline-3-sulfonamides
Intermediate Tree Nodes Not available
Direct Parent Quinoline-3-sulfonamides
Alternative Parents Diphenylethers  Phenylpyrimidines  4-aminoquinolines  Diarylethers  Pyridinesulfonamides  Aminobenzoic acids  Benzoic acids  Aniline and substituted anilines  Phenoxy compounds  Benzoyl derivatives  Phenol ethers  Fluorobenzenes  Alkyl aryl ethers  Aminopyridines and derivatives  Organosulfonamides  Primary aromatic amines  Aryl fluorides  Aminosulfonyl compounds  Heteroaromatic compounds  Amino acids  Carboxylic acids  Azacyclic compounds  Secondary amines  Hydrocarbon derivatives  Organic oxides  Organofluorides  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Quinoline-3-sulfonamide - Diphenylether - 5-phenylpyrimidine - Aminoquinoline - 4-aminoquinoline - Diaryl ether - Aminobenzoic acid - Aminobenzoic acid or derivatives - Pyridine-3-sulfonamide - Benzoic acid or derivatives - Benzoic acid - Phenoxy compound - Benzoyl - Phenol ether - Aniline or substituted anilines - Fluorobenzene - Halobenzene - Aminopyridine - Alkyl aryl ether - Organosulfonic acid amide - Monocyclic benzene moiety - Aryl halide - Aryl fluoride - Benzenoid - Pyrimidine - Pyridine - Primary aromatic amine - Heteroaromatic compound - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Aminosulfonyl compound - Sulfonyl - Amino acid or derivatives - Amino acid - Carboxylic acid - Carboxylic acid derivative - Secondary amine - Azacycle - Ether - Amine - Organic oxide - Organohalogen compound - Organofluoride - Organonitrogen compound - Organic oxygen compound - Organooxygen compound - Organosulfur compound - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as quinoline-3-sulfonamides. These are quinolines in which the quinoline ring system is substituted by one sulfonamide group at the 3-position.
External Descriptors Not available

Associated Targets(Human)

LDHB Tchem L-lactate dehydrogenase B chain (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
LDHA Tchem L-lactate dehydrogenase A chain (8 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
LDHA Tchem L-lactate dehydrogenase A chain (1573 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LDHB Tchem L-lactate dehydrogenase B chain (463 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A673 (619 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MIA PaCa-2 (5949 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEL-S-133P L-lactate dehydrogenase (161 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488202259
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488202259
IUPAC Name 3-[[3-(cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino]-5-(3,5-difluorophenoxy)benzoic acid
INCHI InChI=1S/C31H25F2N5O7S/c1-43-29-25(14-35-31(37-29)44-2)16-3-6-24-26(9-16)34-15-27(46(41,42)38-20-4-5-20)28(24)36-21-7-17(30(39)40)8-22(13-21)45-23-11-18(32)10-19(33)12-23/h3,6-15,20,38H,4-5H2,1-2H3,(H,34,36)(H,39,40)
InChIKey RZBCPMYJIARMGV-UHFFFAOYSA-N
Smiles COC1=NC(=NC=C1C2=CC3=NC=C(C(=C3C=C2)NC4=CC(=CC(=C4)C(=O)O)OC5=CC(=CC(=C5)F)F)S(=O)(=O)NC6CC6)OC
Isomeric SMILES COC1=NC(=NC=C1C2=CC3=NC=C(C(=C3C=C2)NC4=CC(=CC(=C4)C(=O)O)OC5=CC(=CC(=C5)F)F)S(=O)(=O)NC6CC6)OC
Molecular Weight 649.62
Reaxy-Rn 23754927
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23754927&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number Certificate Type Date Item
C2413028 Certificate of Analysis Feb 17, 2023 G288241
D2308199 Certificate of Analysis Feb 17, 2023 G288241
D2308215 Certificate of Analysis Feb 17, 2023 G288241
D2308209 Certificate of Analysis Feb 17, 2023 G288241
D2308708 Certificate of Analysis Feb 17, 2023 G288241
D2308211 Certificate of Analysis Feb 17, 2023 G288241
D2308210 Certificate of Analysis Feb 17, 2023 G288241
D2308077 Certificate of Analysis Feb 17, 2023 G288241
D2308688 Certificate of Analysis Feb 17, 2023 G288241
D2308694 Certificate of Analysis Feb 17, 2023 G288241
D2308618 Certificate of Analysis Feb 17, 2023 G288241
L2426209 Certificate of Analysis Feb 17, 2023 G288241

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Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 64.96, Max Conc. mM: 100
Sensitivity light sensitive
Molecular Weight 649.600 g/mol
XLogP3 5.600
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 14
Rotatable Bond Count 11
Exact Mass 649.144 Da
Monoisotopic Mass 649.144 Da
Topological Polar Surface Area 170.000 Ų
Heavy Atom Count 46
Formal Charge 0
Complexity 1140.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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