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GSA10 - ≥96%, high purity , CAS No.300833-95-8, Allosteric modulator of SMO

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GSA10 - ≥96%, high purity , CAS No.300833-95-8, Allosteric modulator of SMO

COA

Grade & Purity:

Moligand™

≥96%

Cas Number: 300833-95-8
Molecular Weight: 450.53
EC Number: 808-811-9
PubChem CID: 54683103

In stock

Item Number

G275761

Grouped product items
SKU	Size	Availability	Price
G275761-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$375.90
G275761-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$676.90
G275761-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,045.90

Smo receptor agonist

View related series

Smo (39) SMO Allosteric modulator (1) Stem Cell/Wnt (1019)

Basic Description

Synonyms	AS-16537 \| AKOS000624567 \| GTPL10326 \| GSA 10; GSA-10 \| J-017772 \| STK034810 \| 4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester \| F82046 \| AG-690/11765216 \| propyl 4-[(1-hexyl-4-hydroxy-2-oxoquinoline-3-carbonyl)amino]b
Specifications & Purity	Moligand™, ≥96%
Biochemical and Physiological Mechanisms	A novel small-molecule Smo receptor agonist. Does not recognize the classic cyclopamine binding site.\xa0May have therapeutic interests in regenerative medicine.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of SMO
Note	Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Shipped at room temperature. Store at -20°C.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Anilides

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Anilides
Intermediate Tree Nodes	Not available
Direct Parent	Aromatic anilides
Alternative Parents	Quinoline-3-carboxamides Hydroxyquinolines Hydroquinolones Hydroquinolines Benzoic acid esters Pyridinecarboxylic acids and derivatives Benzoyl derivatives Pyridinones Hydroxypyridines Vinylogous amides Vinylogous acids Heteroaromatic compounds Secondary carboxylic acid amides Lactams Carboxylic acid esters Monocarboxylic acids and derivatives Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Aromatic anilide - Quinoline-3-carboxamide - Hydroxyquinoline - Dihydroquinolone - Quinoline - Dihydroquinoline - Benzoate ester - Pyridine carboxylic acid or derivatives - Benzoic acid or derivatives - Benzoyl - Hydroxypyridine - Pyridinone - Pyridine - Heteroaromatic compound - Vinylogous amide - Vinylogous acid - Secondary carboxylic acid amide - Lactam - Carboxylic acid ester - Carboxamide group - Azacycle - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as aromatic anilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with an aromatic group. They have the general structure RNC(=O)R', where R= benzene, and R = aryl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

SMO Tclin Smoothened homolog (1 Activities)

Discover Target: SMO

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMO Tclin Smoothened homolog (1371 Activities)

Discover Target: SMO

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

C3H 10T1/2 (488 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	propyl 4-[(1-hexyl-4-hydroxy-2-oxoquinoline-3-carbonyl)amino]benzoate
INCHI	InChI=1S/C26H30N2O5/c1-3-5-6-9-16-28-21-11-8-7-10-20(21)23(29)22(25(28)31)24(30)27-19-14-12-18(13-15-19)26(32)33-17-4-2/h7-8,10-15,29H,3-6,9,16-17H2,1-2H3,(H,27,30)
InChIKey	MDLUYYGRCGDKGL-UHFFFAOYSA-N
Smiles	CCCCCCN1C2=CC=CC=C2C(=C(C1=O)C(=O)NC3=CC=C(C=C3)C(=O)OCCC)O
Isomeric SMILES	CCCCCCN1C2=CC=CC=C2C(=C(C1=O)C(=O)NC3=CC=C(C=C3)C(=O)OCCC)O
Alternate CAS	300833-95-8
Molecular Weight	450.53
Reaxy-Rn	23682377
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23682377&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	Soluble in DMSO to 5 mM warming
Molecular Weight	450.500 g/mol
XLogP3	5.600
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	11
Exact Mass	450.215 Da
Monoisotopic Mass	450.215 Da
Topological Polar Surface Area	95.900 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	726.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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