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GS9667 - 98%, high purity , Adenosine A1 receptor partial agonist, CAS No.618380-90-8, Adenosine A1 receptor partial agonist

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 618380-90-8
Molecular Weight: 461.51
PubChem CID: 11561692

In stock

Item Number

G610679

Grouped product items
SKU	Size	Availability	Price
G610679-1mg	1mg	3	$52.90
G610679-5mg	5mg	3	$250.90
G610679-10mg	10mg	3	$274.90
G610679-25mg	25mg	2	$874.90
G610679-50mg	50mg	1	$879.90
G610679-100mg	100mg	1	$1,399.90

View related series

A1 receptor Agonist (32) A2A receptor Agonist (32) A2B receptor Agonist (19) A3 receptor Agonist (35) Class A GPCR (4138)

Basic Description

Synonyms	GS9667 \| 6E68796C40 \| (2S,3S,4R,5R)-2-[(2-fluorophenyl)sulfanylmethyl]-5-[6-[[(1R,2R)-2-hydroxycyclopentyl]amino]purin-9-yl]oxolane-3,4-diol \| UNII-6E68796C40
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	AGONIST, PARTIAL AGONIST
Mechanism of action	Adenosine A1 receptor partial agonist
Product Description	GS-9667, a selective and partial agonist of the A(1) adenosine receptor (AR).

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Nucleosides, nucleotides, and analogues
  - Class 5'-deoxyribonucleosides
    - Subclass 5'-deoxy-5'-thionucleosides

Kingdom	Organic compounds
Superclass	Nucleosides, nucleotides, and analogues
Class	5'-deoxyribonucleosides
Subclass	5'-deoxy-5'-thionucleosides
Intermediate Tree Nodes	Not available
Direct Parent	5'-deoxy-5'-thionucleosides
Alternative Parents	6-alkylaminopurines Glycosylamines Pentoses Thiophenol ethers Secondary alkylarylamines Alkylarylthioethers Aminopyrimidines and derivatives Fluorobenzenes Aryl fluorides N-substituted imidazoles Imidolactams Cyclopentanols Tetrahydrofurans Heteroaromatic compounds Cyclic alcohols and derivatives Sulfenyl compounds Oxacyclic compounds Azacyclic compounds Organofluorides Organopnictogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	5'-deoxy-5'-thionucleoside - Glycosyl compound - N-glycosyl compound - 6-alkylaminopurine - 6-aminopurine - Pentose monosaccharide - Imidazopyrimidine - Purine - Aryl thioether - Thiophenol ether - Halobenzene - Aminopyrimidine - Fluorobenzene - Secondary aliphatic/aromatic amine - Alkylarylthioether - Aryl halide - Cyclopentanol - Pyrimidine - Aryl fluoride - Monosaccharide - Monocyclic benzene moiety - Benzenoid - N-substituted imidazole - Imidolactam - Cyclic alcohol - Tetrahydrofuran - Imidazole - Heteroaromatic compound - Azole - Secondary alcohol - Oxacycle - Azacycle - Organoheterocyclic compound - Sulfenyl compound - Thioether - Secondary amine - Alcohol - Hydrocarbon derivative - Organopnictogen compound - Organic oxygen compound - Amine - Organic nitrogen compound - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as 5'-deoxy-5'-thionucleosides. These are 5'-deoxyribonucleosides in which the ribose is thio-substituted at the 5'position by a S-alkyl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	2.3

Associated Targets(Human)

ADORA2A Tclin Adenosine receptor A2a (1 Activities)

Discover Target: ADORA2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA2B Tclin Adenosine receptor A2b (1 Activities)

Discover Target: ADORA2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA1 Tclin Adenosine receptor A1 (2 Activities)

Discover Target: ADORA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA3 Tchem Adenosine receptor A3 (1 Activities)

Discover Target: ADORA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA1 Tclin Adenosine A1 receptor (17603 Activities)

Discover Target: ADORA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADORA2A Tclin Adenosine A2a receptor (16305 Activities)

Discover Target: ADORA2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADORA2B Tclin Adenosine A2b receptor (7672 Activities)

Discover Target: ADORA2B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(2S,3S,4R,5R)-2-[(2-fluorophenyl)sulfanylmethyl]-5-[6-[[(1R,2R)-2-hydroxycyclopentyl]amino]purin-9-yl]oxolane-3,4-diol
INCHI	InChI=1S/C21H24FN5O4S/c22-11-4-1-2-7-15(11)32-8-14-17(29)18(30)21(31-14)27-10-25-16-19(23-9-24-20(16)27)26-12-5-3-6-13(12)28/h1-2,4,7,9-10,12-14,17-18,21,28-30H,3,5-6,8H2,(H,23,24,26)/t12-,13-,14-,17-,18-,21-/m1/s1
InChIKey	IZRXENCTXNMAMI-DIJFLQFKSA-N
Smiles	O[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1ncnc2N[C@@H]1CCC[C@H]1O)CSc1ccccc1F
Isomeric SMILES	C1C[C@H]([C@@H](C1)O)NC2=C3C(=NC=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CSC5=CC=CC=C5F)O)O
PubChem CID	11561692
Molecular Weight	461.51

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number	Certificate Type	Date	Item
H2429224	Certificate of Analysis	May 23, 2024	G610679
H2429225	Certificate of Analysis	May 23, 2024	G610679
H2429226	Certificate of Analysis	May 23, 2024	G610679
H2429227	Certificate of Analysis	May 23, 2024	G610679
H2429228	Certificate of Analysis	May 23, 2024	G610679
H2429234	Certificate of Analysis	May 23, 2024	G610679
H2429236	Certificate of Analysis	May 23, 2024	G610679
H2429238	Certificate of Analysis	May 23, 2024	G610679
H2429239	Certificate of Analysis	May 23, 2024	G610679
H2429246	Certificate of Analysis	May 23, 2024	G610679
H2429223	Certificate of Analysis	May 23, 2024	G610679
H2429245	Certificate of Analysis	May 23, 2024	G610679

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Chemical and Physical Properties

Molecular Weight	461.500 g/mol
XLogP3	2.300
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	6
Exact Mass	461.153 Da
Monoisotopic Mass	461.153 Da
Topological Polar Surface Area	151.000 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	641.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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