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GNE-490 - 98%, high purity , CAS No.1033739-92-2

COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
G412349
Grouped product items
SKU Size
Availability
 Price Qty
G412349-1mg
1mg
3
$121.90
G412349-5mg
5mg
3
$329.90
G412349-10mg
10mg
3
$534.90
G412349-25mg
25mg
3
$846.90
G412349-50mg
50mg
2
$1,168.90
G412349-100mg
100mg
1
$1,586.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
mTOR (145) pan-PI3K inhibitor (1) PI3K (243) PI3K/Akt/mTOR (765)

Basic Description

Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms GNE-490 is a highly selective pan-PI3K inhibitor that demonstrates selectivity over mTOR.
Storage Temp Protected from light,Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Information

GNE-490 is a highly selective pan-PI3K inhibitor that demonstrates selectivity over mTOR.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Thienopyrimidines
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Thienopyrimidines
Alternative Parents Dialkylarylamines  2,3,5-trisubstituted thiophenes  Aminopyrimidines and derivatives  Morpholines  Imidolactams  Tertiary alcohols  Heteroaromatic compounds  Oxacyclic compounds  Dialkyl ethers  Azacyclic compounds  Primary amines  Hydrocarbon derivatives  Aromatic alcohols  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Thienopyrimidine - 2,3,5-trisubstituted thiophene - Dialkylarylamine - Aminopyrimidine - Morpholine - Oxazinane - Pyrimidine - Imidolactam - Heteroaromatic compound - Tertiary alcohol - Thiophene - Tertiary amine - Oxacycle - Azacycle - Dialkyl ether - Ether - Amine - Organooxygen compound - Organonitrogen compound - Alcohol - Hydrocarbon derivative - Primary amine - Organic nitrogen compound - Aromatic alcohol - Organic oxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as thienopyrimidines. These are heterocyclic compounds containing a thiophene ring fused to a pyrimidine ring. Thiophene is 5-membered ring consisting of four carbon atoms and one sulfur atom. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions.
External Descriptors Not available

Associated Targets(Human)

PIK3CG Tclin Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PIK3CA Tclin Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PIK3CB Tchem Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PIK3CD Tclin Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SYK Tclin Tyrosine-protein kinase SYK (7372 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIK3CD Tclin PI3-kinase p110-delta subunit (6699 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIK3CG Tclin PI3-kinase p110-gamma subunit (5411 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PI4KB Tchem PI4-kinase beta subunit (1593 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAP3K9 Tchem Mitogen-activated protein kinase kinase kinase 9 (945 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIK3CB Tchem PI3-kinase p110-beta subunit (4044 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-3 (62116 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIK3C2B Tchem Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (438 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIK3C3 Tchem Phosphatidylinositol 3-kinase catalytic subunit type 3 (535 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

PIK3CA PI3-kinase p110-alpha subunit (51 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasma (328 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 2-[2-(2-amino-4-methylpyrimidin-5-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]propan-2-ol
INCHI InChI=1S/C18H22N6O2S/c1-10-11(9-20-17(19)21-10)15-22-12-8-13(18(2,3)25)27-14(12)16(23-15)24-4-6-26-7-5-24/h8-9,25H,4-7H2,1-3H3,(H2,19,20,21)
InChIKey SFWTVVNNVHWDEE-UHFFFAOYSA-N
Smiles CC1=NC(=NC=C1C2=NC3=C(C(=N2)N4CCOCC4)SC(=C3)C(C)(C)O)N
Isomeric SMILES CC1=NC(=NC=C1C2=NC3=C(C(=N2)N4CCOCC4)SC(=C3)C(C)(C)O)N
Molecular Weight 386.47
Reaxy-Rn 20433735
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20433735&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot Number Certificate Type Date Item
C2421355 Certificate of Analysis Feb 29, 2024 G412349
C2421356 Certificate of Analysis Feb 29, 2024 G412349
C2421351 Certificate of Analysis Feb 29, 2024 G412349
C2421352 Certificate of Analysis Feb 29, 2024 G412349
C2421353 Certificate of Analysis Feb 29, 2024 G412349
C2421354 Certificate of Analysis Feb 29, 2024 G412349
C2421357 Certificate of Analysis Feb 29, 2024 G412349
C2421359 Certificate of Analysis Feb 29, 2024 G412349
C2421360 Certificate of Analysis Feb 29, 2024 G412349
C2421363 Certificate of Analysis Feb 29, 2024 G412349
C2421365 Certificate of Analysis Feb 29, 2024 G412349

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Chemical and Physical Properties

Sensitivity Light sensitive
Molecular Weight 386.500 g/mol
XLogP3 1.100
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 3
Exact Mass 386.152 Da
Monoisotopic Mass 386.152 Da
Topological Polar Surface Area 139.000 Ų
Heavy Atom Count 27
Formal Charge 0
Complexity 520.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

Reviews

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