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GNE 220 hydrochloride - 98%, high purity , CAS No.2448286-21-1

COA

Grade & Purity:

≥98%

Cas Number: 2448286-21-1
Molecular Weight: 474.99
PubChem CID: 134828260

In stock

Item Number

G651637

Grouped product items
SKU	Size	Availability	Price
G651637-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$650.90
G651637-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,200.90
G651637-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,600.90

View related series

MAP4K (26) MAPK/ERK Pathway (546)

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4 , with an IC 50 of 7 nM.
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4 , with an IC 50 of 7 nM. In Vitro GNE-220 also inhibits a few other kinases with IC 50 s of 9 nM, 476 nM and 1.1 μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM + retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1 + long focal adhesions (FAs). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:MAP4K4 7 nM (IC 50 ) MAP4K5 9 nM (IC 50 ) MAP4K6 1.1 μM (IC 50 ) DMPK 476 nM (IC 50 )

Names and Identifiers

IUPAC Name	6-methyl-12-[4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrazol-4-yl)-3,5,8,10-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaene;hydrochloride
INCHI	InChI=1S/C25H26N8.ClH/c1-16-22-23(30-24(28-16)19-14-27-32(3)15-19)21-12-18(13-26-25(21)29-22)17-4-6-20(7-5-17)33-10-8-31(2)9-11-33;/h4-7,12-15H,8-11H2,1-3H3,(H,26,29);1H
InChIKey	VBVBAEHNBOTZQV-UHFFFAOYSA-N
Smiles	CC1=C2C(=NC(=N1)C3=CN(N=C3)C)C4=C(N2)N=CC(=C4)C5=CC=C(C=C5)N6CCN(CC6)C.Cl
PubChem CID	134828260
Molecular Weight	474.99

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 5.4 mg/mL (11.37 mM; Need ultrasonic) H2O : 5 mg/mL (10.53 mM; Need ultrasonic)

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