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GNE-131 - 10mM in DMSO, high purity , CAS No.1629063-81-5(DMSO), Inhibitor of Na v1.1;Inhibitor of Na v1.2;Inhibitor of Na v1.5;Inhibitor of Na v1.6;Inhibitor of Na v1.7

COA COA
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Item Number
G654724
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G654724-1ml
1ml
Available within 8-12 weeks(?)
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$377.90
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Compound libraries (12325) Membrane Transporter/Ion Channel (1822) Sodium Channel (211)

Basic Description

Specifications & Purity Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7 , with an IC 50 of 3 nM.
Storage Temp Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of Na v1.1;Inhibitor of Na v1.2;Inhibitor of Na v1.5;Inhibitor of Na v1.6;Inhibitor of Na v1.7
Product Description

GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7 , with an IC 50 of 3 nM.

In Vitro

GNE-131 (Compound 13) shows moderate clearance in human liver microsomes and excellent functional activity against human NaV1.7 with an IC 50 of 0.003±0.001 μM. GNE-131 shows excellent potency, good in vitro metabolic stability. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GNE-131 shows low in vivo clearance in mouse, rat, and dog. GNE-131 also displays excellent efficacy in a transgenic mouse model of induced pain . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Na v 1.7 3 nM (IC 50 )

Associated Targets(Human)

SCN2A Tclin Sodium channel protein type 2 subunit alpha (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SCN5A Tclin Sodium channel protein type 5 subunit alpha (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SCN9A Tclin Sodium channel protein type 9 subunit alpha (5 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SCN1A Tclin Sodium channel protein type 1 subunit alpha (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SCN8A Tclin Sodium channel protein type 8 subunit alpha (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Names and Identifiers

Smiles C1CC1C2=CN3C(=NN=C3NS(=O)(=O)C4CC4)C=C2OCC56CC7CC(C5)CC(C7)C6
Molecular Weight 442.57

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

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