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GN 44028 - ≥98%(HPLC), high purity , CAS No.1421448-26-1

COA COA
    Grade & Purity:
  • ≥98%(HPLC)
In stock
Item Number
G288045
Grouped product items
SKU Size
Availability
 Price Qty
G288045-5mg
5mg
3
$276.90
G288045-10mg
10mg
2
$498.90
G288045-25mg
25mg
2
$1,121.90
G288045-50mg
50mg
2
$2,019.90
G288045-100mg
100mg
2
$3,634.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Potent HIF-1α inhibitor

View related series
Glucose Metabolism (1943) HIF/HIF Prolyl-Hydroxylase (128) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine | GN44028
Specifications & Purity ≥98%(HPLC)
Biochemical and Physiological Mechanisms Potent HIF-1αinhibitor (IC50= 14 nM). Inhibits hypoxia-induced HIF-1αtranscriptional activity without suppressing HIF-1αmRNA expression, HIF-1αprotein accumulation, or HIF-1α/HIF-1βheterodimerization. Cytotoxic to a range of cancer cell typesin vitro.
Storage Temp Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Benzodioxanes
Subclass Benzo-1,4-dioxanes
Intermediate Tree Nodes Not available
Direct Parent Benzo-1,4-dioxanes
Alternative Parents Alkyl aryl ethers  Para dioxins  Imidolactams  Benzenoids  Pyrazoles  Heteroaromatic compounds  Oxacyclic compounds  Azacyclic compounds  Hydrocarbon derivatives  Amines  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Benzo-1,4-dioxane - Alkyl aryl ether - Para-dioxin - Benzenoid - Imidolactam - Azole - Pyrazole - Heteroaromatic compound - Ether - Oxacycle - Azacycle - Amine - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as benzo-1,4-dioxanes. These are heterocyclic compounds containing a benzene ring fused to a 1,4-dioxane ring.
External Descriptors Not available

Associated Targets(Human)

HIF1A Tchem Hypoxia-inducible factor 1-alpha (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PC-3 (62116 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCT-116 (91556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HeLa (62764 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504772186
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504772186
IUPAC Name N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
INCHI InChI=1S/C18H15N3O2/c1-2-4-13-11(3-1)9-14-17(13)20-21-18(14)19-12-5-6-15-16(10-12)23-8-7-22-15/h1-6,10H,7-9H2,(H2,19,20,21)
InChIKey CGZKSZVSWAAUHE-UHFFFAOYSA-N
Smiles C1COC2=C(O1)C=CC(=C2)NC3=NNC4=C3CC5=CC=CC=C54
Isomeric SMILES C1COC2=C(O1)C=CC(=C2)NC3=NNC4=C3CC5=CC=CC=C54
Molecular Weight 305.33
Reaxy-Rn 23401922
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23401922&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Item
K2218469 Certificate of Analysis Aug 29, 2022 G288045
K2218453 Certificate of Analysis Aug 29, 2022 G288045
K2218456 Certificate of Analysis Aug 29, 2022 G288045
K2218455 Certificate of Analysis Aug 29, 2022 G288045
K2218454 Certificate of Analysis Aug 29, 2022 G288045

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 30.53, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 30.53, Max Conc. mM: 100
Molecular Weight 305.300 g/mol
XLogP3 3.500
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 2
Exact Mass 305.116 Da
Monoisotopic Mass 305.116 Da
Topological Polar Surface Area 59.200 Ų
Heavy Atom Count 23
Formal Charge 0
Complexity 434.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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