Basic Description

Synonyms	AMMONIUM GLYCYRRHIZINATE \| Ammonium glycyrrhizate \| 53956-04-0 \| Monoammonium glycyrrhizinate \| Glycamil \| Glycyrram \| Monoammonium glycyrrhizate \| 1407-03-0 \| AMGZ \| Ammoniated glycyrrhizin \| Glycyrrhizic acid, ammonium salt \| Glycyrrhizic acid ammonium salt \| Glycyrrhizic acid
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Glycyrrhizic acid salt. Cytoprotective agent. Inhibits ROS production. Shows anti-inflammatory and antinociceptive effects in vivo.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Ammonium Glycyrrhizinate is used in the synthesis of polyion complex nanocarriers which may act as a template for the design of other negatively charged water-soluble drugs. Particularly for anti-inflammatory drugs with which Ammonium Glycyrrhizinate is associated.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lipids and lipid-like molecules
  - Class Prenol lipids
    - Subclass Terpene glycosides
      - Level5 Triterpene glycosides
        Level6 Triterpene saponins

Kingdom	Organic compounds
Superclass	Lipids and lipid-like molecules
Class	Prenol lipids
Subclass	Terpene glycosides
Intermediate Tree Nodes	Triterpene glycosides
Direct Parent	Triterpene saponins
Alternative Parents	Triterpenoids O-glucuronides Disaccharides O-glycosyl compounds Tricarboxylic acids and derivatives Beta hydroxy acids and derivatives Cyclohexenones Pyrans Oxanes Secondary alcohols Acetals Polyols Carboxylic acids Oxacyclic compounds Organic oxides Hydrocarbon derivatives Organic nitrogen compounds
Molecular Framework	Aliphatic heteropolycyclic compounds
Substituents	Triterpene saponin - Triterpenoid - 1-o-glucuronide - O-glucuronide - Glucuronic acid or derivatives - Disaccharide - Glycosyl compound - O-glycosyl compound - Tricarboxylic acid or derivatives - Cyclohexenone - Beta-hydroxy acid - Pyran - Hydroxy acid - Oxane - Secondary alcohol - Ketone - Organoheterocyclic compound - Polyol - Acetal - Carboxylic acid - Carboxylic acid derivative - Oxacycle - Organic oxide - Organic oxygen compound - Alcohol - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organooxygen compound - Aliphatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as triterpene saponins. These are glycosylated derivatives of triterpene sapogenins. The sapogenin moiety backbone is usually based on the oleanane, ursane, taraxastane, bauerane, lanostane, lupeol, lupane, dammarane, cycloartane, friedelane, hopane, 9b,19-cyclo-lanostane, cycloartane, or cycloartanol skeleton.
External Descriptors	organic molecular entity
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid;azane
INCHI	InChI=1S/C42H62O16.H3N/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50;/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54);1H3/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+;/m0./s1
InChIKey	ILRKKHJEINIICQ-OOFFSTKBSA-N
Smiles	CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C.N
Isomeric SMILES	C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O[C@@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C(=O)O)O)O)O)C)(C)C(=O)O.N
WGK Germany	2
RTECS	LZ6500000
Molecular Weight	839.96
Beilstein	3897076
Reaxy-Rn	30023600
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30023600&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Specific Rotation[α]	49 ° (C=1.5, EtOH)
Melt Point(°C)	209°C
Molecular Weight	840.000 g/mol
XLogP3
Hydrogen Bond Donor Count	9
Hydrogen Bond Acceptor Count	17
Rotatable Bond Count	7
Exact Mass	839.43 Da
Monoisotopic Mass	839.43 Da
Topological Polar Surface Area	268.000 Å²
Heavy Atom Count	59
Formal Charge	0
Complexity	1730.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	19
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Jiajia Jin, Jun chen, Xin Shou, Keqing Shi, Xingjie Zan, Yan Zu, Xiaoying Huang. (2023) MAG-encapsulated PLGA microspheres for Lipopolysaccharide-induced acute lung injury. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 86 (104632).
2. Shaowei Tan, Qiyuan Li, Liwei Guo, Yongxiang Wang, Wenwei Zhong. (2023) Investigation of foaming behavior in herbal extracts via the characterization of solution environment for reverse osmosis concentration. FOOD AND BIOPRODUCTS PROCESSING, 137 (28).
3. Hao Zhang, Nan Tang, Xia Yu, Zhongkai Guo, Zhen Liu, Xiaoming Sun, Min-Hui Li, Jun Hu. (2022) Natural glycyrrhizic acid-tailored hydrogel with in-situ gradient reduction of AgNPs layer as high-performance, multi-functional, sustainable flexible sensors. CHEMICAL ENGINEERING JOURNAL, 430 (132779).

Solution Calculators

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Glycyrrhizic acid ammonium salt - 10mM in DMSO, high purity , CAS No.53956-04-0