Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Taille | Disponibilité |
Prix | Qté |
---|---|---|---|---|
G127198-5g
|
5g |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
24,90$US
|
|
G127198-25g
|
25g |
2
|
79,90$US
|
|
G127198-100g
|
100g |
2
|
199,90$US
|
|
K + channel blocker
Synonymes | Bastiverit | Daonil | Semi-daonil | Euglucan | Glucolon | Glibenil | glyburide | Duraglucon | Glibenclamide | Glybenclamide | Azuglucon | Glynase | Benclamin | Renabetic | Orabetic | Apo-Glibenclamide | Glybenzcyclamide | Micronase | Betanase | Euglucon | |
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Spécifications et pureté | Moligand™, ≥99% |
Mécanismes biochimiques et physiologiques | Glibenclamide is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. |
Température de stockage | Store at 2-8°C |
Expédié en |
Wet ice Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles. |
Grade | Moligand™ |
Type d'action | BLOCKER, CHANNEL BLOCKER, INHIBITOR |
Mécanisme d'action | Sulfonylurea receptor 1, Kir6.2 blocker |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description |
Glibenclamide(Glyburide) is a sulfonylurea compound that modulates insulin production. |
Taxonomy Tree
Kingdom | Organic compounds |
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Superclass | Benzenoids |
Classe | Benzene and substituted derivatives |
Subclass | Benzenesulfonamides |
Intermediate Tree Nodes | Not available |
Direct Parent | Benzenesulfonamides |
Alternative Parents | Benzenesulfonyl compounds Anisoles Methoxybenzenes Phenoxy compounds Chlorobenzenes Sulfonylureas Alkyl aryl ethers Aryl chlorides Aminosulfonyl compounds Organosulfonic acids and derivatives Carboximidic acids Propargyl-type 1,3-dipolar organic compounds Organopnictogen compounds Organochlorides Organic oxides Hydrocarbon derivatives |
Molecular Framework | Aromatic homomonocyclic compounds |
Substituents | Benzenesulfonamide - Benzenesulfonyl group - Anisole - Phenol ether - Methoxybenzene - Phenoxy compound - Chlorobenzene - Halobenzene - Sulfonylurea - Alkyl aryl ether - Aryl chloride - Aryl halide - Aminosulfonyl compound - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Carboximidic acid - Carboximidic acid derivative - Organic 1,3-dipolar compound - Ether - Propargyl-type 1,3-dipolar organic compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Organohalogen compound - Organochloride - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Aromatic homomonocyclic compound |
Description | This compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring. |
External Descriptors | monochlorobenzenes - N-sulfonylurea |
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ALogP | 4.8 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | Références |
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Pubchem Sid | 504750678 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504750678 |
IUPAC Name | 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide |
INCHI | InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29) |
InChIKey | ZNNLBTZKUZBEKO-UHFFFAOYSA-N |
Smiles | COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3 |
Isomères SMILES | COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3 |
WGK Allemagne | 2 |
RTECS | YS4725200 |
Poids moléculaire | 494 |
Reaxy-Rn | 2230085 |
Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2230085&ln= |
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Article |
---|---|---|---|
Certificate of Analysis | Aug 12, 2024 | G127198 | |
Certificate of Analysis | Jul 12, 2024 | G127198 | |
Certificate of Analysis | Jul 06, 2024 | G127198 | |
Certificate of Analysis | Jul 06, 2024 | G127198 | |
Certificate of Analysis | Jul 06, 2024 | G127198 | |
Certificate of Analysis | Sep 14, 2023 | G127198 | |
Certificate of Analysis | Sep 14, 2023 | G127198 | |
Certificate of Analysis | Sep 14, 2023 | G127198 | |
Certificate of Analysis | Jul 06, 2023 | G127198 | |
Certificate of Analysis | Jul 28, 2022 | G127198 | |
Certificate of Analysis | Jul 28, 2022 | G127198 | |
Certificate of Analysis | Jul 28, 2022 | G127198 |
Solubilité | Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water. |
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Sensibilité | heat sensitive |
Indice de réfraction | 1.62 |
Point de fusion (°C) | 171-174°C |
Poids moléculaire | 494.000 g/mol |
XLogP3 | 4.800 |
Hydrogen Bond Donor Count | 3 |
Hydrogen Bond Acceptor Count | 5 |
Rotatable Bond Count | 8 |
Exact Mass | 493.144 Da |
Monoisotopic Mass | 493.144 Da |
Topological Polar Surface Area | 122.000 Ų |
Heavy Atom Count | 33 |
Formal Charge | 0 |
Complexity | 746.000 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
The total count of all stereochemical bonds | 0 |
Covalently-Bonded Unit Count | 1 |
1. Qiang Gao, Ali Farajtabar. (2024) Glyburide in a series co-solvent solutions: Solubility and modeling, solvation and quantum chemistry research. JOURNAL OF CHEMICAL THERMODYNAMICS, 189 (107195). |
2. Changhong Yuan, Wenwen Fan, Tengfei Zhou, Dianjun Sun, Hongzhuo Liu, Zhonggui He, Yongjun Wang. (2023) Ligand-free high loading capacity ursolic acid self-carried nanovesicles enable hepatocyte targeting via absorbing apolipoproteins. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 638 (122931). |
3. Zixian He, Zhiwei Liu, Haihuan Xie, Pengjie Luo, Xiangmei Li. (2023) An Ultrasensitive Lateral Flow Immunoassay Based on Metal-Organic Framework-Decorated Polydopamine for Multiple Sulfonylureas Adulteration in Functional Foods. Foods, 12 (3): (539). |
4. Haihuan Xie, Yingying Li, Jin Wang, Yi Lei, Anastasios Koidis, Xiangmei Li, Xing Shen, Zhenlin Xu, Hongtao Lei. (2022) Broad-specific immunochromatography for simultaneous detection of various sulfonylureas in adulterated multi-herbal tea. FOOD CHEMISTRY, 370 (131055). |
5. Yun-Jing Zhang, Wen-Li Zhou, Fei Yu, Qian Wang, Can Peng, Jia-Yi Kan. (2021) Evaluation of the effect of Bovis Calculus Artifactus on eight rat liver cytochrome P450 isozymes using LC-MS/MS and cocktail approach. XENOBIOTICA, 51 (9): (1010-1018). |
6. Song-Yang Zhang, Yong-Qiang Dong, Pengcheng Wang, Xingzhong Zhang, Yu Yan, Lulu Sun, Bo Liu, Dafang Zhang, Heng Zhang, Huiying Liu, Wei Kong, Gang Hu, Yatrik M. Shah, Frank J. Gonzalez, Xian Wang, Changtao Jiang. (2018) Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance. EBioMedicine, 31 (202). |
7. Benhong Xu, Huixing Deng, Xiaojing Zhang, Jingxiong Luo, Gaoxiao Zhang, Zaijun Zhang, Yuqiang Wang, Luchen Shan. (2018) A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs. EUROPEAN JOURNAL OF PHARMACOLOGY, 818 (158). |
8. Qiao-Lai Wang, Pei-Xi Zhang, Rui Shen, Meng Xu, Liang Han, Xuan Shi, Zi-Rui Zhou, Jing-Yi Yang, Jie-Qing Liu. (2024) Determination of arbutin in vitro and in vivo by LC-MS/MS: Pre-clinical evaluation of natural product arbutin for its early medicinal properties. JOURNAL OF ETHNOPHARMACOLOGY, 330 (118232). |
9. Chuanxi Tian, Jinyue Zhao, Qian Wang, Keke Luo, Shuang Zhao, Li Wan, Jiarui Li, Kaile Ma, Yanyan Zhou, Min Li. (2024) Exploring the therapeutic efficacy: Unveiling the active compounds of Huashi Baidu granules against COVID-19. Arabian Journal of Chemistry, 17 (105910). |