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Glucosylceramide synthase-IN-1 - 99%, high purity , CAS No.2601393-20-6

COA

Grade & Purity:

≥99%

Cas Number: 2601393-20-6
Molecular Weight: 460.42

In stock

Item Number

G649607

Grouped product items
SKU	Size	Availability	Price
G649607-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$380.90
G649607-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$620.90
G649607-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,250.90

View related series

Glucosylceramide Synthase (GCS) (14) Neuronal Signaling (3320)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Glucosylceramide synthase-IN-1 (T-036) a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC 50 s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase-IN-1 can be used for Gaucher'
Storage Temp	Store at 2-8°C,Protected from light,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Glucosylceramide synthase-IN-1 (T-036) a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC 50 s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase-IN-1 can be used for Gaucher's disease research In Vitro Glucosylceramide synthase-IN-1 (T-036) potently reduces the GCS product, catalyze glucosylceramide (GlcCer), in the fibroblasts with Gaucher’s disease (EC 50 of 7.6 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Glucosylceramide synthase-IN-1 (T-036) has good oral exposure (BA = 67%) and moderate brain penetration ( Kpuu,brain = 0.11). Administration of a single dose of Glucosylceramide synthase-IN-1 (T-036) reduces GlcCer in the plasma and cerebral cortex of wild-type mice, and administration of Glucosylceramide synthase-IN-1 (T-036) for 2 months significantly reduces glucosylsphingosine (GlcSph) in the cerebral cortex of the Gaucher’s disease mouse model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 31 nM (human GCS) and 51 nM (mouse GCS)

Names and Identifiers

Smiles	FC1=CC(OCC(F)(F)F)=C(C2=NC=CC3=C2CN(C4=CC=C(C(C)(O)C)C=C4)C3=O)C=C1
Molecular Weight	460.42

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