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Glucosamine - 95%, high purity , Supplement, CAS No.3416-24-8, Supplement

In stock
Item Number
G413437
Grouped product items
SKU Size
Availability
Price Qty
G413437-5mg
5mg
2
$9.90
G413437-25mg
25mg
2
$35.90
G413437-100mg
100mg
3
$95.90
G413437-250mg
250mg
2
$216.90
G413437-1g
1g
1
$777.90

HIF Inhibitors

Basic Description

Synonyms 2-Amino-2-Deoxy-D-Glucopyranose | BRN 1724602 | N08U5BOQ1K | 4-04-00-02017 (Beilstein Handbook Reference) | DB01296 | Glucosamine free base | 2-Amino-2-Deoxy-D-Glucopyranoside | D-Glucose, 2-amino-2-deoxy- | methyl-3-(chlorosulfonyl)thiophene-2-carboxylat
Specifications & Purity Isomer mixture, ≥95%
Biochemical and Physiological Mechanisms Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine(GS) treatment selectively downregulate
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Isomer mixture
Mechanism of action Supplement
Product Description

Information

Glucosamine Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine(GS) treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.

Product Properties

pKa pKₐ: 12.27 (Predicted), pKₐ: 8.44 (Predicted)

Associated Targets(Human)

F2 Tclin Thrombin (11687 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-1080 (3966 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MG-63 (795 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC22A1 Tchem Solute carrier family 22 member 1 (646 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FIBCD1 Tbio Fibrinogen C domain-containing protein 1 (33 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Mmp2 Matrix metalloproteinase-2 (12 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RAW (181 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cartilage (29 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trametes versicolor (86 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Poria (18 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504758692
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504758692
Smiles C([C@@H]1[C@H]([C@@H]([C@H](C(O1)O)N)O)O)O
Isomeric SMILES C([C@@H]1[C@H]([C@@H]([C@H](C(O1)O)N)O)O)O
RTECS LZ6665000
Molecular Weight 179.17
Beilstein 1423209
Reaxy-Rn 1423209
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1423209&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

21 results found

Lot Number Certificate Type Date Item
E2515039 Certificate of Analysis May 16, 2024 G413437
B2506081 Certificate of Analysis May 16, 2024 G413437
F2427312 Certificate of Analysis May 16, 2024 G413437
F2427313 Certificate of Analysis May 16, 2024 G413437
F2427326 Certificate of Analysis May 16, 2024 G413437
F2427327 Certificate of Analysis May 16, 2024 G413437
F2427328 Certificate of Analysis May 16, 2024 G413437
H2303598 Certificate of Analysis Jul 28, 2023 G413437
H2303602 Certificate of Analysis Jul 28, 2023 G413437
H2303613 Certificate of Analysis Jul 28, 2023 G413437
H2303586 Certificate of Analysis Jul 28, 2023 G413437
H2303623 Certificate of Analysis Jul 28, 2023 G413437
H2303634 Certificate of Analysis Jul 28, 2023 G413437
C2426057 Certificate of Analysis Jul 28, 2023 G413437
C2426058 Certificate of Analysis Jul 28, 2023 G413437
H2303603 Certificate of Analysis Jul 28, 2023 G413437
H2303589 Certificate of Analysis Jul 28, 2023 G413437
H2303599 Certificate of Analysis Jul 28, 2023 G413437
H2303591 Certificate of Analysis Jul 28, 2023 G413437
D2318896 Certificate of Analysis Apr 12, 2023 G413437
D2318913 Certificate of Analysis Apr 12, 2023 G413437

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Chemical and Physical Properties

Solubility Solubility (25°C) In vitro Water: 36 mg/mL (200.92 mM); DMSO: 23 mg/mL (128.36 mM); Ethanol: Insoluble;
Refractive Index n20D1.6 (Predicted)
Boil Point(°C) ~449.9° C at 760 mmHg (Predicted)
Melt Point(°C) 109-111° C
Molecular Weight 179.170 g/mol
XLogP3 -2.800
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 1
Exact Mass 179.079 Da
Monoisotopic Mass 179.079 Da
Topological Polar Surface Area 116.000 Ų
Heavy Atom Count 12
Formal Charge 0
Complexity 155.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 4
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

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2. Qihong Jiang, Lin Chen, Rui Wang, Yin Chen, Shanggui Deng, Guoxin Shen, Shulai Liu, Xingwei Xiang.  (2024)  Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathway.  Food Science and Human Wellness,  13  (842). 
3. Yang Liu, Limei Ran, Yahong Wang, Peng Wan, Hongli Zhou.  (2023)  Basic characterization, antioxidant and immunomodulatory activities of polysaccharides from sea buckthorn leaves.  FITOTERAPIA,  169  (105592). 
4. Shuwei Yuan, Jiahui Wang, Xiang Li, Xun Zhu, Zhenqing Zhang, Duxin Li.  (2023)  Study on the structure, antioxidant activity and degradation pattern of polysaccharides isolated from lotus seedpod.  CARBOHYDRATE POLYMERS,  316  (121065). 
5. Cui Cao, Lilong Wang, Xueqian Zhang, Chunqing Ai, Zhongfu Wang, Linjuan Huang, Shuang Song, Beiwei Zhu.  (2023)  Interaction between Bacteroidetes species in the fermentation of Lycium barbarum arabinogalactan.  FOOD CHEMISTRY,  409  (135288). 
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7. Dongxue Cao, Enwei Wei, Zeyu Wang, Zhengyu Hu, Ling Qi, Hongli Zhou, Jingli Zhao.  (2022)  Microwave-assisted extraction, structural elucidation, and in vitro anti-glioma and immunostimulatory activity of polysaccharide from Panax ginseng C. A. Meyer.  INDUSTRIAL CROPS AND PRODUCTS,  189  (115729). 
8. Jinfang Zhang, Baoyue Zhu, Xiaojian Xu, Yihan Liu, Qinggang Li, Yu Li, Fuping Lu.  (2022)  Remodeling Bacillus amyloliquefaciens Cell Wall Rigidity to Reduce Cell Lysis and Increase the Yield of Heterologous Proteins.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  70  (34): (10552–10562). 
9. Zhengyu Hu, Ruiying Yu, Jinfeng Sun, Yuanqi Duan, Hongli Zhou, Wei Zhou, Gao Li.  (2022)  Static decolorization of polysaccharides from the leaves of Rhododendron dauricum: Process optimization, characterization and antioxidant activities.  PROCESS BIOCHEMISTRY,  121  (113). 
10. Lei Li, Yun Fang, Yongmei Xia, Chunling Bo, Ye Fan.  (2022)  Monosaccharides driving the formation of conjugated linoleic acid vesicles in near-neutral solutions via weak noncovalent bonding interactions.  JOURNAL OF MOLECULAR LIQUIDS,  351  (118656). 
11. Hualing Xie, Jingyu Fang, Mohamed A. Farag, Zhenhao Li, Peilong Sun, Ping Shao.  (2022)  Dendrobium officinale leaf polysaccharides regulation of immune response and gut microbiota composition in cyclophosphamide-treated mice.  Food Chemistry-X,  13  (100235). 
12. Yilin Zhang, Mengqi Wu, Jingrui Xi, Chen Pan, Zhizhen Xu, Wei Xia, Wenqing Zhang.  (2021)  Multiple-fingerprint analysis of Poria cocos polysaccharide by HPLC combined with chemometrics methods.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  198  (114012). 
13. Xiaoguo Ji, Mai Chen, Mengyao Zhao, Yudong Song, Yong Lin, Hao Yin, Liming Zhao.  (2021)  Effects of chitooligosaccharides on the rebalance of gut microorganisms and their metabolites in patients with nonalcoholic fatty liver disease.  Journal of Functional Foods,  77  (104333). 
14. Yuhuan Ma, Wenwei Zheng, Houhuang Chen, Xiang Shao, Pingdong Lin, Xianxiang Liu, Xihai Li, Hongzhi Ye.  (2018)  Glucosamine promotes chondrocyte proliferation via the Wnt/β‑catenin signaling pathway.  INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,  42  (1): (61-70). 
15. Li Guo, Shan Huang, Jinqing Qu.  (2018)  Synthesis and properties of high-functionality hydroxyl-terminated polyurethane dispersions.  PROGRESS IN ORGANIC COATINGS,  119  (214). 
16. Hongyan Zhu, Wanwan Liu, Ziting Cheng, Ke Yao, Yu Yang, Bohui Xu, Gaoxing Su.  (2017)  Targeted Delivery of siRNA with pH-Responsive Hybrid Gold Nanostars for Cancer Treatment.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  18  (10): (2029). 
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18. Ying-Hua Zhang, Jia-Qi Liu, Di Xu, Xin-Huai Zhao.  (2015)  Impacts of glucosamine/oligochitosan glycation and cross-linking by transglutaminase on the structure and in vitro antigenicity of whey proteins.  INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY,  69  (2): (169-176). 
19. Zhen Yao, Kehan Zhu, Tianyi Gu, Oliver J. Schmitz, Duxin Li.  (2024)  An active derivatization detection method for inline monitoring the isolation of carbohydrates by preparative liquid chromatography.  JOURNAL OF CHROMATOGRAPHY A,    (464730). 
20. Liying Hao, Jikui Sun, Qingyin Wang, Haijiao Xie, Xiangui Yang, Qiang Wei.  (2024)  Application of Mesoporous Carbon-Based Highly Dispersed K–O2 Strong Lewis Base in the Efficient Catalysis of Methanol and Ethylene Carbonate.  ACS Applied Materials & Interfaces,  16  (32): (42080-42092). 
21. Juncheng Liu, Xingyu Lu, Fang Fang, Kaizhang Wu, Jihong Wu, Jie Gao.  (2024)  Comparison of the in-vitro effect of five prebiotics with different structure on gut microbiome and metabolome.  Food Bioscience,    (103810). 
22. He Li, Changxin Zheng, Yanru Zheng, Kai Wen, Yingjiu Zhang.  (2024)  Distinct functional diversity of branched oligosaccharides as chaperones and inhibitory-binding partners of amyloid beta-protein and its aggregates.  NEUROPHARMACOLOGY,    (110141). 
23. Yuanqi Duan, Zhengyu Hu, Long Jin, Tieqiang Zong, Xiaohui Zhang, Yanan Liu, Pengcheng Yang, Jinfeng Sun, Wei Zhou, Gao Li.  (2024)  Efficient degradation and enhanced anticomplementary activity of Belamcanda chinensis (L.) DC. polysaccharides via trifluoroacetic acid treatment with different degrees.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,    (134117). 
24. Xiaohui Zhang, Zhengyu Hu, Yuanqi Duan, Yuxin Jiang, Weiwei Xu, Pengcheng Yang, Wei Zhou, Jinfeng Sun, Gao Li.  (2024)  Extraction, characterization, and neuroprotective effects of polysaccharides the stems of Panax ginseng C. A. Meyer by three different solvents (water, acid, alkali).  INDUSTRIAL CROPS AND PRODUCTS,  222  (119512). 
25. Weiwei Xu, Wei Zhou, Jinfeng Sun, Weiwei Chen, Xuanye Wu, Tong Guan, Yilin Zhao, Pengcheng Yang, Zhengyu Hu, Gao Li.  (2024)  Isolation, structural characterization, and hypoglycemic activity of polysaccharides from the stems of Panax ginseng C. A. Meyer.  Frontiers in Sustainable Food Systems,   
26. Qijun Yu, Jinshui Yang, Liang Liu, Yaru Huang, Entao Wang, Dongmei Li, Hongli Yuan.  (2025)  One-step immobilization of chitosanase on microcrystalline cellulose using a carbohydrate binding module family 2.  CARBOHYDRATE POLYMERS,  353  (123291). 
27. Menghan Yuan, Xinyue Huang, Shuang Tian, Shixuan Ma, Yuxing Guo, Mingxuan Tao.  (2024)  Selenized modification and structural characterization of Pleurotus eryngii polysaccharides and their immunomodulatory activity.  PROCESS BIOCHEMISTRY,  144  (97). 
28. Wenli Lei, Shuang Zhang, Jiaxi Shu, Fudong Li, Zixuan Deng, Juejing Liu, Xiaofeng Guo, Yuanmeng Zhao, Changsheng Shan.  (2025)  Self-Powered Glucose Biosensor Based on Non-Enzymatic Biofuel Cells by Au Nanocluster/Pd Nanocube Heterostructure and Fe3C@C-Fe Single-Atom Catalyst.  Small,    (2410326). 
29. Hong Ding, Xuanxiao Lu, Xiaoguo Ji, Shijie Wang, Jiayang Jin, Mengyao Zhao, Xiaofeng Hang, Liming Zhao.  (2024)  Synthesis of glucosamine-selenium compound and evaluation of its oral toxicity and in vitro anti-hepatitis B virus activity.  CHEMICO-BIOLOGICAL INTERACTIONS,    (111184). 
30. Qingyue Zhu, Wenhan Xu, Changqing Zhang, Jiabao Gong, Xinguang Qin, Haizhi Zhang, Gang Liu.  (2024)  Transglutaminase-mediated glycosylation enhances the physicochemical and functional properties of ovalbumin.  FOOD HYDROCOLLOIDS,    (109992). 

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