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GLP-2(3-33) - 99%, high purity , CAS No.275801-62-2

COA

Grade & Purity:

≥99%

Cas Number: 275801-62-2
Molecular Weight: 3557.89

In stock

Item Number

G649313

Grouped product items
SKU	Size	Availability	Price	Qty
G649313-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$280.90
G649313-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$850.90

View related series

Class B GPCR (170) GCGR (64) GPCR/G Protein (3172)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor ( EC 50 =5.8 nM).
Storage Temp	Desiccated,Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor ( EC 50 =5.8 nM). In Vitro GLP-2 is secreted as a 33-amino acid peptide, but is rapidly degraded at an N-terminus site to GLP-2(3-33) in circulation, in large part, by dipeptidylpeptidase IV (DPPIV). GLP-2 (3-33) acts as a partial agonist with potential competitive antagonistic properties on the GLP-2 receptor. In the GLP-2 receptor-binding assay, the binding IC 50 for GLP-2 1–33 was 3.1 nM, and it was 41 nM for GLP-2 3-33. Thus, GLP-2 3–33 had 7.5% binding affinity compared to GLP-2 1-33. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo GLP-2(3-33) (60 ng; once a day i.p. for 4 weeks) increases dyslipidemia and hepatic lipid accumulation in HFD-fed mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male C57BL/6J (B6) mice (HFD)Dosage: 60 ng Administration: Once a day i.p. for 4 weeks Result: Significantly affected plasma lipids; Showed increase of triglycerides and cholesterol and reduction of HDL; Significantly increased plasma ALT and AST and intrahepatic lipid concentration. Form:Solid

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