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GLP-1(32-36)amide - 98%, high purity , CAS No.1417302-71-6

COA

Grade & Purity:

≥98%

Cas Number: 1417302-71-6
Molecular Weight: 570.73

In stock

Item Number

G648329

Grouped product items
SKU	Size	Availability	Price	Qty
G648329-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$275.90
G648329-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$465.90

View related series

Class B GPCR (170) GCGR (64) GPCR/G Protein (3172)

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1 . GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice.
Storage Temp	Desiccated,Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice. In Vitro GLP-1(32-36)amide (0.1-10 μM; 24 h) retains cell viability and decreases apoptosis against Streptozotocin (STZ; 1 μM) in INS-1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: INS-1 cells Concentration: 0.1, 1, 10 μM Incubation Time: 24 hours Result: Decreased cell viability only approximately 30% in 0.1 μM and approximately 20% in ≥1 μM while approximately 45% in saline-treated controls. In Vivo GLP-1(32-36)amide (1 μmol/kg; i.p. once daily for 21 d) protects islet from damage, inhibits weight gain, and relieves symptoms of polydipsia in diabetic mice. GLP-1(32-36)amide (1 μmol/kg; a single i.p.) slightly reduces the mean glucose lever at 30 min after the challenge of glucose in normal mice. GLP-1(32-36)amide (50-70 nmol/kg/d; infusion for 12-16 weeks) prevents the development of diet-induced obesity and hepatic steatosis in high fat-fed mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male KM mice (6-8 weeks; 18-22 g) injected with STZDosage: 1 μmol/kg Administration: I.p. once daily for 21 days Result: Signiﬁcantly lowered the cumulative values of food and water intake. Lowered fasting glucose. Reduced the level of Hemoglobin A1c (HbA1c). Improved glucose tolerance. Suppressed body weight gain. Form:Solid

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GLP-1(32-36)amide - 98%, high purity , CAS No.1417302-71-6

Basic Description

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