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Glembatumumab vedotin (anti-GPNMB) - Primary antibody, specific to GPNMB, >90% (SDS-PAGE&SEC), high purity, Human IgG2SA, BINDING AGENT of Transmembrane glycoprotein NMB binding agent, BINDING AGENT of Transmembrane glycoprotein NMB binding agent

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human,Mouse
  • Isotype: Human IgG2SA
  • Conjugation: MC-VC-PAB-MMAE
In stock
Item Number
Ab175551
Grouped product items
SKU Size
Availability
Price Qty
Ab175551-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$189.90
Ab175551-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$919.90
Ab175551-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,299.90
Ab175551-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$3,679.90

Purity>90% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2SA; CHO; ELISA, FACS, Functional assay, Animal Model; Conjugated (MC-VC-PAB-MMAE)

Basic Description

Product Name Glembatumumab vedotin (anti-GPNMB) - Primary antibody, specific to GPNMB, >90% (SDS-PAGE&SEC), high purity, Human IgG2SA, BINDING AGENT of Transmembrane glycoprotein NMB binding agent
Synonyms Glycoprotein (transmembrane) nmb antibody | Glycoprotein nmb antibody | Glycoprotein nmb like protein antibody | Gpnmb antibody | GPNMB_HUMAN antibody | HGFIN antibody | NMB antibody | Osteoactivin antibody | Transmembrane glycoprotein antibody | Transmem
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity GPNMB
Conjugation MC-VC-PAB-MMAE
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type BINDING AGENT
Mechanism of action BINDING AGENT of Transmembrane glycoprotein NMB binding agent
Product Description

Glembatumumab vedotin (anti-GPNMB) is an ADC (antibody-drug conjugates (ADCs)) comprising a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB) and conjugated to the potent tubulinbinding cytotoxic agent MMAE via a protease-sensitive vc linker. Glembatumumab vedotin (anti-GPNMB) has potent anticancer effects.

Product Properties

Isotype Human IgG2SA
Light Chain Type kappa
SDS-PAGE 145.56 kDa
Purification Method Protein A purified
Purity >90% (SDS-PAGE&SEC)
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1182215-65-1

Associated Targets(Human)

GPNMB Tbio Transmembrane glycoprotein NMB (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Glembatumumab vedotin (anti-GPNMB) (Ab175551) - ELISA
Immobilized Recombinant SYDX-C076-huGPNMB-his protein at 2.0 μg/mL can bind Glembatumumab vedotin (anti-GPNMB) (Ab175551) with the EC50 of 13.88 ng/mL.

Glembatumumab vedotin (anti-GPNMB) (Ab175551) - SEC
The purity of Glembatumumab vedotin (anti-GPNMB) (Ab175551) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

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Customer Reviews

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