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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab175551-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$189.90
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Ab175551-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$919.90
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Ab175551-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,299.90
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Ab175551-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$3,679.90
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Purity>90% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2SA; CHO; ELISA, FACS, Functional assay, Animal Model; Conjugated (MC-VC-PAB-MMAE)
| Product Name | Glembatumumab vedotin (anti-GPNMB) - Primary antibody, specific to GPNMB, >90% (SDS-PAGE&SEC), high purity, Human IgG2SA, BINDING AGENT of Transmembrane glycoprotein NMB binding agent |
|---|---|
| Synonyms | Glycoprotein (transmembrane) nmb antibody | Glycoprotein nmb antibody | Glycoprotein nmb like protein antibody | Gpnmb antibody | GPNMB_HUMAN antibody | HGFIN antibody | NMB antibody | Osteoactivin antibody | Transmembrane glycoprotein antibody | Transmem |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | GPNMB |
| Conjugation | MC-VC-PAB-MMAE |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | BINDING AGENT |
| Mechanism of action | BINDING AGENT of Transmembrane glycoprotein NMB binding agent |
| Product Description |
Glembatumumab vedotin (anti-GPNMB) is an ADC (antibody-drug conjugates (ADCs)) comprising a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB) and conjugated to the potent tubulinbinding cytotoxic agent MMAE via a protease-sensitive vc linker. Glembatumumab vedotin (anti-GPNMB) has potent anticancer effects.
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| Isotype | Human IgG2SA |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 145.56 kDa |
| Purification Method | Protein A purified |
| Purity | >90% (SDS-PAGE&SEC) |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1182215-65-1 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Glembatumumab vedotin (anti-GPNMB) (Ab175551) - ELISA
Immobilized Recombinant SYDX-C076-huGPNMB-his protein at 2.0 μg/mL can bind Glembatumumab vedotin (anti-GPNMB) (Ab175551) with the EC50 of 13.88 ng/mL.
Glembatumumab vedotin (anti-GPNMB) (Ab175551) - SEC
The purity of Glembatumumab vedotin (anti-GPNMB) (Ab175551) is more than 95% verified by HPLC.