Skip to the beginning of the images gallery

GGTI-2154 hydrochloride - 98%, high purity , CAS No.478908-50-8

COA

Grade & Purity:

≥98%

Cas Number: 478908-50-8
Molecular Weight: 456.97

In stock

Item Number

G650372

Grouped product items
SKU	Size	Availability	Price	Qty
G650372-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$620.90
G650372-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$980.90

View related series

Apoptosis (4276) Protein Tyrosine Kinase/RTK (1314) ROS Kinase (27)

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	GGTI-2154 hydrochloride is a potent and selective inhibitor geranylgeranyltransferase I (GGTase I) , with an IC 50 of 21 nM. GGTI-2154 hydrochloride shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 hydrochloride can b
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	GGTI-2154 hydrochloride is a potent and selective inhibitor geranylgeranyltransferase I (GGTase I) , with an IC 50 of 21 nM. GGTI-2154 hydrochloride shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 hydrochloride can be used for the research of cancer In Vitro GGTI-2154 inhibits the transfer of geranylgeranyl from [ 3 H]GGPP to H-Ras CVLL, with an IC 50 of 21 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo GGTI-2154 (100 mg/kg/day; s.c. for 14 days) induces breast tumor regression in MMTV-ν-Ha-Ras transgenic mice. GGTI-2154 (50 mg/kg/day; i.p. for 50 day) inhibits A-549 tumor growth in nude mice by 60% . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MMTV-v-Ha-ras transgenic mice bearing mammary carcinomaDosage: 100 mg/kg/day Administration: S.c. with osmotic mini-pumps for 14 days Result: Halted the tumors aggressive growth. Resulted in rapid tumor regression within 3 days of initiation of drug treatment. Form:Solid IC50& Target:IC50: 21 nM (GGTase I)

Names and Identifiers

Smiles	CC(C)C[C@@H](C(O)=O)NC(C1=CC=C(NCC2=CN=CN2)C=C1C3=CC=CC=C3C)=O.[H]Cl
Molecular Weight	456.97

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 250 mg/mL (547.08 mM; Need ultrasonic) H2O : 4.76 mg/mL (10.42 mM; ultrasonic and warming and heat to 60°C)

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration