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Gepotidacin - 98%, high purity , Bacterial DNA gyrase inhibitor, CAS No.1075236-89-3, Bacterial DNA gyrase inhibitor

COA COA
In stock
Item Number
G610547
Grouped product items
SKU Size
Availability
 Price Qty
G610547-1mg
1mg
1
$109.90
G610547-5mg
5mg
1
$359.90
G610547-10mg
10mg
1
$699.90
G610547-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,399.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
Antibiotic (1629) Bacterial (3013) Bacterial-Topoisomerase (1) Cell Cycle (2830)

Basic Description

Synonyms GSK 2140944 | GSK2140944 | GSK-2140944
Specifications & Purity Moligand™, ≥98%
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Bacterial DNA gyrase inhibitor
Product Description

Gepotidacin is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Pyranopyridines
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Pyranopyridines
Alternative Parents Pyridopyrazines  Imidazopyridines  Imidazopyrazines  2-pyridylmethylamines  Pyridinones  Alkyl aryl ethers  Aminopiperidines  Aralkylamines  Pyrazines  Heteroaromatic compounds  Azoles  Trialkylamines  Lactams  Oxacyclic compounds  Dialkylamines  Azacyclic compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Pyranopyridine - Pyridopyrazine - Imidazopyridine - Imidazopyrazine - 2-pyridylmethylamine - Alkyl aryl ether - 4-aminopiperidine - Pyridinone - Aralkylamine - Pyridine - Pyrazine - Piperidine - Heteroaromatic compound - Azole - Tertiary aliphatic amine - Tertiary amine - Lactam - Oxacycle - Secondary amine - Azacycle - Secondary aliphatic amine - Ether - Hydrocarbon derivative - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Organic oxygen compound - Amine - Organic oxide - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as pyranopyridines. These are polycyclic aromatic compounds containing a pyran ring fused to a pyridine ring.
External Descriptors Not available

Product Properties

ALogP 0.1

Associated Targets(Human)

TOP2A Tclin DNA topoisomerase II alpha (6317 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Homo sapiens (32628 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Streptococcus pneumoniae (31063 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Enterobacter cloacae (7976 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Neisseria gonorrhoeae (1461 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Salmonella sp. (105 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Haemophilus influenzae (8812 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Streptococcus agalactiae (1777 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
gyrB DNA gyrase (2092 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name (3R)-3-[[4-(3,4-dihydro-2H-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.04,12]dodeca-6,8(12),9-triene-5,11-dione
INCHI InChI=1S/C24H28N6O3/c31-22-4-3-20-24-29(22)15-19(30(24)23(32)13-27-20)14-28-7-5-17(6-8-28)25-11-18-10-16-2-1-9-33-21(16)12-26-18/h3-4,10,12-13,17,19,25H,1-2,5-9,11,14-15H2/t19-/m1/s1
InChIKey PZFAZQUREQIODZ-LJQANCHMSA-N
Smiles O=c1cnc2c3n1[C@H](CN1CCC(CC1)NCc1ncc4c(c1)CCCO4)Cn3c(=O)cc2
Isomeric SMILES C1CC2=CC(=NC=C2OC1)CNC3CCN(CC3)C[C@@H]4CN5C(=O)C=CC6=C5N4C(=O)C=N6
PubChem CID 25101874
Molecular Weight 448.52

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number Certificate Type Date Item
G2415204 Certificate of Analysis Apr 01, 2024 G610547
G2415205 Certificate of Analysis Apr 01, 2024 G610547
G2415206 Certificate of Analysis Apr 01, 2024 G610547
G2415207 Certificate of Analysis Apr 01, 2024 G610547
G2415208 Certificate of Analysis Apr 01, 2024 G610547
G2415209 Certificate of Analysis Apr 01, 2024 G610547
G2415210 Certificate of Analysis Apr 01, 2024 G610547

Chemical and Physical Properties

Molecular Weight 448.500 g/mol
XLogP3 0.100
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 5
Exact Mass 448.222 Da
Monoisotopic Mass 448.222 Da
Topological Polar Surface Area 90.400 Ų
Heavy Atom Count 33
Formal Charge 0
Complexity 893.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 1
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

Reviews

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