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Gemcitabine hydrochloride - 98%, high purity , DNA polymerase (alpha/delta/epsilon) inhibitor, CAS No.122111-03-9, DNA polymerase (alpha/delta/epsilon) inhibitor

2 Citations COA COA
In stock
Item Number
G120180
Grouped product items
SKU Size
Availability
 Price Qty
G120180-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$9.90
G120180-50mg
50mg
3
$11.90
G120180-250mg
250mg
3
$13.90
G120180-1g
1g
2
$22.90
G120180-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$72.90
G120180-10g
10g
1
$119.90
G120180-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$199.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Potent, specific deoxycytidine analog

View related series
Apoptosis (4276) Autophagy (1917) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) DNA/RNA Synthesis (362) Nucleoside Antimetabolite/Analog (200) Nucleosides (90) Pyrimidines (539) Six-Membered Heterocyclic Compounds (1696)

Basic Description

Synonyms EX-A837 | Gemcitabine (as hydrochloride) | Gemcitabine HCL (Gemzar) | INFUGEM | NSC613327 | Gemcitabine hydrochloride [USAN] | LY 188011 hydrochloride | BG164501 | Gemzar (TN) | GEMCITABINE HYDROCHLORIDE [VANDF] | dFdC | dFdCyd | 2′-Deoxy-2′,2′-difluorocy
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms Gemcitabine hydrochloride is used for treatment of non-small cell lung cancer, pancreatic cancer, mammary cancer, ovarian cancer, bladder cancer, nasopharyngeal carcinoma and non-Hodgkin's lymphoma.Deoxycytidine analog that inhibits DNA synthesis. Metabol
Storage Temp Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action DNA polymerase (alpha/delta/epsilon) inhibitor
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.This product is only used for scientific research.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Nucleosides, nucleotides, and analogues
Class Pyrimidine nucleosides
Subclass Pyrimidine 2'-deoxyribonucleosides
Intermediate Tree Nodes Not available
Direct Parent Pyrimidine 2'-deoxyribonucleosides
Alternative Parents Pyrimidones  Aminopyrimidines and derivatives  Hydropyrimidines  Imidolactams  Tetrahydrofurans  Heteroaromatic compounds  Secondary alcohols  Fluorohydrins  Azacyclic compounds  Oxacyclic compounds  Organic oxides  Hydrochlorides  Hydrocarbon derivatives  Organofluorides  Organopnictogen compounds  Primary alcohols  Primary amines  Alkyl fluorides  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Pyrimidine 2'-deoxyribonucleoside - Aminopyrimidine - Pyrimidone - Hydropyrimidine - Pyrimidine - Imidolactam - Heteroaromatic compound - Tetrahydrofuran - Fluorohydrin - Halohydrin - Secondary alcohol - Oxacycle - Organoheterocyclic compound - Azacycle - Hydrochloride - Organic oxide - Organopnictogen compound - Primary amine - Primary alcohol - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Organic oxygen compound - Alkyl fluoride - Alcohol - Organic nitrogen compound - Amine - Hydrocarbon derivative - Alkyl halide - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as pyrimidine 2'-deoxyribonucleosides. These are compounds consisting of a pyrimidine linked to a ribose which lacks a hydroxyl group at position 2.
External Descriptors hydrochloride - organofluorine compound

Associated Targets(Human)

MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCT-116 (91556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H460 (60772 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A2780 (11979 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (1191 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ABCB11 Tchem Bile salt export pump (2311 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ABCC3 Tbio Canalicular multispecific organic anion transporter 2 (718 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ABCC4 Tchem Multidrug resistance-associated protein 4 (785 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
L02 (4864 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

TRAMP-C1A (16 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
C2D cell line (11 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
C2G cell line (11 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TRAMP-C2H (17 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Blood (6 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504753714
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504753714
IUPAC Name 4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride
INCHI InChI=1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1
InChIKey OKKDEIYWILRZIA-OSZBKLCCSA-N
Smiles Cl.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)C2(F)F
Isomeric SMILES C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F.Cl
WGK Germany 3
RTECS HA3840000
Molecular Weight 299.66
Reaxy-Rn 5386970
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5386970&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

22 results found

Lot Number Certificate Type Date Item
F2506549 Certificate of Analysis May 15, 2025 G120180
F2506550 Certificate of Analysis May 15, 2025 G120180
F2121157 Certificate of Analysis Apr 03, 2025 G120180
E1308012 Certificate of Analysis Jan 20, 2025 G120180
K2406356 Certificate of Analysis Oct 19, 2024 G120180
K2406357 Certificate of Analysis Oct 19, 2024 G120180
K2406358 Certificate of Analysis Oct 19, 2024 G120180
K2406359 Certificate of Analysis Oct 19, 2024 G120180
D2415053 Certificate of Analysis Mar 30, 2024 G120180
D2415054 Certificate of Analysis Mar 30, 2024 G120180
D2415055 Certificate of Analysis Mar 30, 2024 G120180
D2415056 Certificate of Analysis Mar 30, 2024 G120180
D2415057 Certificate of Analysis Mar 30, 2024 G120180
D2415058 Certificate of Analysis Mar 30, 2024 G120180
J1811195 Certificate of Analysis Aug 11, 2022 G120180
J1811194 Certificate of Analysis Aug 11, 2022 G120180
F2222064 Certificate of Analysis Jun 01, 2022 G120180
F2222062 Certificate of Analysis Jun 01, 2022 G120180
F2222056 Certificate of Analysis Jun 01, 2022 G120180
F2222060 Certificate of Analysis Jun 01, 2022 G120180
F2222019 Certificate of Analysis Jun 01, 2022 G120180
I2406189 Certificate of Analysis May 07, 2021 G120180

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Chemical and Physical Properties

Sensitivity Heat & Light sensitive；Moisture sensitive
Refractive Index 268
Specific Rotation[α] 48°C
Melt Point(°C) 292°C
Molecular Weight 299.660 g/mol
XLogP3
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 2
Exact Mass 299.048 Da
Monoisotopic Mass 299.048 Da
Topological Polar Surface Area 108.000 Ų
Heavy Atom Count 19
Formal Charge 0
Complexity 426.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 3
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Alternative Products

  1. Gemcitabine hydrochloride, DNA polymerase (alpha/delta/epsilon) inhibitor
    Gemcitabine hydrochloride, DNA polymerase (alpha/delta/epsilon) inhibitor
    • 10mM in Water

    Starting at $28.90

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Zhimei Wang, Yuehuan Zhang, Qing Chen, Xin Xiao, Carl Redshaw.  (2023)  Preparation of pelargonic acid vesicles and sustained drug release.  Canadian Journal of Chemistry,  101  (2):  
2. Yadong Tang,Boxin Huang,Yuqin Dong,Wenlong Wang,Xi Zheng,Wei Zhou,Kun Zhang,Zhiyun Du.  (2017-06-07)  Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy..  Journal of biomaterials science. Polymer edition,  28  ((14)): (1603-1616). 

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