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Ganetespib (STA-9090) - ≥98%, high purity , Heat shock protein HSP90 inhibitor, CAS No.888216-25-9, Heat shock protein HSP90 inhibitor

1 Citations COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
G127078
Grouped product items
SKU Size
Availability
 Price Qty
G127078-1mg
1mg
3
$15.90
G127078-5mg
5mg
3
$57.90
G127078-25mg
25mg
3
$127.90
G127078-100mg
100mg
1
$249.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Potent Hsp90 inhibitor

View related series
Amino Acid/Protein Metabolism (1836) Apoptosis (4276) Cell Cycle/DNA Damage (2602) DNA Damage (697) HSP (135) Hsp90 inhibitor (1) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms EX-A250 | 3-(2,4-Dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-1H-1,2,4-triazol-5(4H)-one | AS-35117 | FT-0700397 | 3-(2,4-dihydroxy-5-propan-2-ylphenyl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one | HMS3654K12 | BCP22669 | CHEBI:177770 | GANE
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Ganetespib is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM for OSA 8 cells. Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor Ganet
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type INHIBITOR
Mechanism of action Heat shock protein HSP90 inhibitor
Note Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Ganetespib(STA-9090) is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells.
A unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM for OSA 8 cells

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Azoles
Subclass Triazoles
Intermediate Tree Nodes Triazolones
Direct Parent Aryl 1,2,4-triazolones
Alternative Parents Phenyl-1,2,4-triazoles  N-alkylindoles  Phenylpropanes  Indoles  Cumenes  Resorcinols  1-hydroxy-2-unsubstituted benzenoids  N-methylpyrroles  Heteroaromatic compounds  Azacyclic compounds  Organooxygen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Aryl 1,2,4-triazol-3-one - Phenyltriazole - Phenyl-1,2,4-triazole - N-alkylindole - Phenylpropane - Cumene - Indole - Indole or derivatives - Resorcinol - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Benzenoid - Substituted pyrrole - N-methylpyrrole - Monocyclic benzene moiety - Heteroaromatic compound - Pyrrole - Azacycle - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as aryl 1,2,4-triazolones. These are aromatic heterocyclic compounds containing a 1,2,4-triazolone moiety that is substituted at the 5-position with an aryl group.
External Descriptors Not available

Product Properties

ALogP 3.1

Associated Targets(Human)

HSP90B1 Tchem Endoplasmin (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
TRAP1 Tchem Heat shock protein 75 kDa, mitochondrial (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HSP90AA1 Tchem Heat shock protein HSP 90-alpha (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HSP90AB1 Tchem Heat shock protein HSP 90-beta (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HSP90AA1 Tchem Heat shock protein HSP 90-alpha (4115 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSP90AB1 Tchem Heat shock protein HSP 90-beta (1689 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A-375 (9258 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-3 (62116 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H1299 (3248 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HaCaT (4069 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCT-116 (91556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H460 (60772 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HeLa (62764 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSP90B1 Tchem Endoplasmin (514 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TRAP1 Tchem Heat shock protein 75 kDa, mitochondrial (274 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H2228 (1030 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSP90AA1 Tchem Heat shock protein HSP90 (3606 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK-293T (167025 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LN-229 (376 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSP90B1 Heat shock protein 90 beta (139 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504773389
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504773389
IUPAC Name 3-(2,4-dihydroxy-5-propan-2-ylphenyl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one
INCHI InChI=1S/C20H20N4O3/c1-11(2)14-9-15(18(26)10-17(14)25)19-21-22-20(27)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,25-26H,1-3H3,(H,22,27)
InChIKey RVAQIUULWULRNW-UHFFFAOYSA-N
Smiles CC(C)C1=C(C=C(C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)O)O
Isomeric SMILES CC(C)C1=C(C=C(C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)O)O
Molecular Weight 364.4
Reaxy-Rn 11457851
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11457851&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot Number Certificate Type Date Item
F2208143 Certificate of Analysis Mar 22, 2024 G127078
F2208148 Certificate of Analysis Mar 22, 2024 G127078
D2402251 Certificate of Analysis Mar 04, 2024 G127078
D2402253 Certificate of Analysis Mar 04, 2024 G127078
D2402254 Certificate of Analysis Mar 04, 2024 G127078
D2402255 Certificate of Analysis Mar 04, 2024 G127078
D2402256 Certificate of Analysis Mar 04, 2024 G127078
H2120285 Certificate of Analysis Jun 06, 2023 G127078
H2120283 Certificate of Analysis Jun 06, 2023 G127078

Chemical and Physical Properties

Solubility DMSO 40 mg/mL Water <1 mg/mL Ethanol 9 mg/mL
Molecular Weight 364.400 g/mol
XLogP3 3.100
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 3
Exact Mass 364.154 Da
Monoisotopic Mass 364.154 Da
Topological Polar Surface Area 90.100 Ų
Heavy Atom Count 27
Formal Charge 0
Complexity 610.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

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    Ganetespib (STA-9090), Heat shock protein HSP90 inhibitor
    • 10mM in DMSO

    Starting at $64.90

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Lingyun Ruan, Yuanyuan Cao, Caixia Ren, Huan Li, Xuesong Feng, Rongzhang Hao.  (2023)  Hyaluronic Acid-Functionalized Polydopamine Nanoparticles Augment Photothermal Therapy via Synergetic Tumor-Targeting and Heat Shock Protein Inhibition.  ACS Applied Nano Materials,     

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