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Gabexate Mesylate - ≥99%, high purity , CAS No.56974-61-9

2 Citations COA COA
    Grade & Purity:
  • ≥99%
In stock
Item Number
G129271
Grouped product items
SKU Size
Availability
 Price Qty
G129271-5mg
5mg
3
$28.90
G129271-25mg
25mg
3
$117.90
G129271-100mg
100mg
3
$391.90
G129271-250mg
250mg
3
$882.90
G129271-1g
1g
3
$3,175.90
G129271-5g
5g
2
$14,288.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

General serine protease inhibitor

View related series
Amino Acid/Protein Metabolism (1836) Factor Xa (34) Functional group compounds (254) Metabolic Enzyme/Protease (4860) Protease inhibitors (22) Proteasome (85)

Basic Description

Synonyms HMS3370J02 | ethyl 4-[6-(diaminomethylideneamino)hexanoyloxy]benzoate;methanesulfonic acid | Gabexate mesilate (JP17) | GABEXATE MESILATE [WHO-DD] | Tox21_110789 | DTXCID8025591 | 2-methylene-butyraldehyde | AKOS025402087 | EOS | HMS3393A22 | NC00153 | AC
Specifications & Purity ≥99%
Biochemical and Physiological Mechanisms General serine protease inhibitor (K i values are 3.4 nM, 5, 1.8 µM and 2.6 mM at tryptase, thrombin, tyrpsin and kallikrein serine proteases respectively). Additionally inhibits nitric oxide synthase. Displays antithrombotic activity and antitumor effect
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Gabexate mesylate
Serine protease inhibitor.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Benzoic acids and derivatives
Intermediate Tree Nodes Not available
Direct Parent Benzoic acid esters
Alternative Parents Phenol esters  Phenoxy compounds  Benzoyl derivatives  Fatty acid esters  Dicarboxylic acids and derivatives  Sulfonyls  Alkanesulfonic acids  Organosulfonic acids  Carboxylic acid esters  Guanidines  Propargyl-type 1,3-dipolar organic compounds  Carboximidamides  Organic oxides  Organic salts  Carbonyl compounds  Organopnictogen compounds  Hydrocarbon derivatives  
Molecular Framework Not available
Substituents Benzoate ester - Phenol ester - Phenoxy compound - Benzoyl - Fatty acid ester - Dicarboxylic acid or derivatives - Fatty acyl - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Organosulfonic acid - Sulfonyl - Alkanesulfonic acid - Carboxylic acid ester - Guanidine - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboxylic acid derivative - Carboximidamide - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic oxide - Organopnictogen compound - Carbonyl group - Organic salt - Organosulfur compound - Hydrocarbon derivative - Organic nitrogen compound - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as benzoic acid esters. These are ester derivatives of benzoic acid.
External Descriptors Not available

Associated Targets(Human)

PTH1R Tclin Parathyroid hormone receptor (47172 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KLK7 Tchem Kallikrein 7 (657 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Pseudomonas aeruginosa (123386 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504764291
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504764291
IUPAC Name ethyl 4-[6-(diaminomethylideneamino)hexanoyloxy]benzoate;methanesulfonic acid
INCHI InChI=1S/C16H23N3O4.CH4O3S/c1-2-22-15(21)12-7-9-13(10-8-12)23-14(20)6-4-3-5-11-19-16(17)18;1-5(2,3)4/h7-10H,2-6,11H2,1H3,(H4,17,18,19);1H3,(H,2,3,4)
InChIKey DNTNDFLIKUKKOC-UHFFFAOYSA-N
Smiles CCOC(=O)C1=CC=C(C=C1)OC(=O)CCCCCN=C(N)N.CS(=O)(=O)O
Isomeric SMILES CCOC(=O)C1=CC=C(C=C1)OC(=O)CCCCCN=C(N)N.CS(=O)(=O)O
Molecular Weight 417.48
Reaxy-Rn 26001927
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26001927&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number Certificate Type Date Item
D2222114 Certificate of Analysis Jan 14, 2025 G129271
D2222123 Certificate of Analysis Jan 14, 2025 G129271
D2222125 Certificate of Analysis Jan 14, 2025 G129271
I2227300 Certificate of Analysis Jul 15, 2024 G129271
I2227303 Certificate of Analysis Jul 15, 2024 G129271
I2227298 Certificate of Analysis Jul 15, 2024 G129271
I2227299 Certificate of Analysis Jul 15, 2024 G129271
H1520105 Certificate of Analysis Mar 09, 2023 G129271

Chemical and Physical Properties

Solubility DMSO 83 mg/mL Water 12 mg/mL Ethanol 83 mg/mL
Melt Point(°C) 91 °C
Molecular Weight 417.500 g/mol
XLogP3
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 8
Rotatable Bond Count 11
Exact Mass 417.157 Da
Monoisotopic Mass 417.157 Da
Topological Polar Surface Area 180.000 Ų
Heavy Atom Count 28
Formal Charge 0
Complexity 493.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Wen Zhang, Xu-Dong Wang, Xiao-Han Zhang, Rui Feng, Jun-Long Wang, Wei-Bao Kong, Ji Zhang, Jun-Yu Liang.  (2023)  Biological activities of Elsholtzia stauntoni essential oil and its major constituents against Tribolium castaneum larvae and Lasioderma serricorne adults.  Journal of Essential Oil Bearing Plants,     
2. Han Liu, Yezhou Ni, Jing Hu, Yameng Jin, Peng Gu, Hua Qiu, Kunlin Chen.  (2022)  Self-Healing and Antibacterial Essential Oil-Loaded Mesoporous Silica/Polyacrylate Hybrid Hydrogel for High-Performance Wearable Body-Strain Sensing.  ACS Applied Materials & Interfaces,  14  (18): (21509–21520). 

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