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FzM1.8 - 98%, high purity , CAS No.2204290-85-5, Allosteric modulator of FZD 4

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 2204290-85-5
Molecular Weight: 322.32
PubChem CID: 137553171
PubChem SID: 504773500

In stock

Item Number

F288778

Grouped product items
SKU	Size	Availability	Price
F288778-5mg	5mg	3	$100.90
F288778-10mg	10mg	2	$167.90
F288778-25mg	25mg	1	$345.90
F288778-50mg	50mg	1	$642.90
F288778-100mg	100mg	1	$1,157.90

Frizzled 4 allosteric agonist; exhibits biased siginaling; preserves stemness

View related series

FZD4 Allosteric modulator (2) Stem Cell/Wnt (1019) Wnt (104) β-catenin (56)

Basic Description

Synonyms	3-Hydroxy-5-[[(2-Naphthalenylamino)carbonyl]amino]benzoic acid
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	FzM1.8 comes from FzM1 and is an allosteric agonist of FZD4 with a pEC50 of 6.4. FzM1.8 promotes TCF/LEF transcriptional activity in the absence of any WNT ligand, binds to FZD4, and activates WNT/ β- The catenin pathway. FzM1.8 binds to stable FZD4, incr
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of FZD 4

Associated Targets(Human)

FZD4 Tchem Frizzled-4 (1 Activities)

Discover Target: FZD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	504773500
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504773500
IUPAC Name	3-hydroxy-5-(naphthalen-2-ylcarbamoylamino)benzoic acid
INCHI	InChI=1S/C18H14N2O4/c21-16-9-13(17(22)23)8-15(10-16)20-18(24)19-14-6-5-11-3-1-2-4-12(11)7-14/h1-10,21H,(H,22,23)(H2,19,20,24)
InChIKey	XGNNCRZDDAJBFU-UHFFFAOYSA-N
Smiles	C1=CC=C2C=C(C=CC2=C1)NC(=O)NC3=CC(=CC(=C3)C(=O)O)O
Molecular Weight	322.32
Reaxy-Rn	32313897
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32313897&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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10 results found

Lot Number	Certificate Type	Date	Item
F2302870	Certificate of Analysis	Apr 21, 2023	F288778
F2302871	Certificate of Analysis	Apr 21, 2023	F288778
F2302863	Certificate of Analysis	Apr 21, 2023	F288778
F2302862	Certificate of Analysis	Apr 21, 2023	F288778
F2302868	Certificate of Analysis	Apr 21, 2023	F288778
F2302869	Certificate of Analysis	Apr 21, 2023	F288778
F2302864	Certificate of Analysis	Apr 21, 2023	F288778
F2302865	Certificate of Analysis	Apr 21, 2023	F288778
F2302867	Certificate of Analysis	Apr 21, 2023	F288778
F2302866	Certificate of Analysis	Apr 21, 2023	F288778

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 32.23, Max Conc. mM: 100

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