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FX-11 - 98%, high purity , CAS No.213971-34-7

COA

Grade & Purity:

≥98%

Cas Number: 213971-34-7
Molecular Weight: 350.41
PubChem CID: 10498042

In stock

Item Number

F650409

Grouped product items
SKU	Size	Availability	Price
F650409-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$38.90
F650409-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$93.90
F650409-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$139.90
F650409-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$309.90
F650409-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$549.90

View related series

Apoptosis (4276) Glucose Metabolism (1943) Immunology/Inflammation (1929) Lactate Dehydrogenase (31) Metabolic Enzyme/Protease (4860) NF-κB (747) Pyruvate Kinase (17) Reactive Oxygen Species (309)

Basic Description

Synonyms	7-benzyl-2,3-dihydroxy-6-methyl-4-propyl-naphthalene-1-carboxylic Acid \| 7-benzyl-2,3-dihydroxy-6-methyl-4-propylnaphthalene-1-carboxylic acid \| SCHEMBL233361 \| NCGC00249596-01 \| BDBM50066974 \| FX 11 \| LDHA Inhibitor FX11 \| LDHA Inhibitor, 3 \| HY-16214 \|
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A (LDHA) inhibitor, with a Ki of 8 μM. FX-11 reduces ATP levels and induces oxidative stress, ROS production and cell death. FX-11 shows antitumor activity in lymphoma and panc
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A ( LDHA ) specific inhibitor, with a K i of 8 μM. FX-11 can effectively activate PKM2 (pyruvate kinase M2). FX-11 reduces ATP levels and induces oxidative stress, ROS production and cell death. FX-11 shows antitumor activity in lymphoma and pancreatic cancer xenografts In Vitro FX-11 (9 μM, 24-48 h) shows activation of AMP kinase and phosphorylation of its substrate acetyl-CoA carboxylase. ?\nFX-11 (0-100 μM, 72 h) inhibits cell proliferation in BxPc-3 and MIA PaCa-2 cells. ?\nFX-11 inhibits glycolysis and alters cellular energy metabolism in P493 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: P493 cells Concentration: 9 μM Incubation Time: 24 h, 48 h Result: Showed a decrease in ATP levels, accompanied by activation of AMP kinase and phosphorylation of its substrate acetyl-CoA carboxylase. Cell Proliferation AssayCell Line: BxPc-3 and MIA PaCa-2 cells Concentration: 0-100 µM Incubation Time: 72 h Result: Reduced cell metabolic activity in a concentration-dependent manner, showed a significant reduction in cell proliferation, with IC 50 values of 49.27 µM and 60.54 µM for BxPc-3 and MIA PaCa-2 cells, respectively. In Vivo FX-11 (42 μg/mouse; IP, daily for 10-14 days) inhibits P493 tumor growth. ?\nFX-11 (0-2 mg/kg, IP, daily, for 3 weeks) significantly delays tumor growth. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male SCID mice and RH-Foxn1nu mice (human P493 B-cell xenografts)Dosage: 42 µg/mouse (2.1 mg/kg) Administration: IP; daily for 10-14 days Result: Resulted in a remarkable inhibition of tumor growth, inhibited tumor xenograft progression. Animal Model: Immunocompromised CD-1 mice (6-8 weeks; 20-25 g, n=5 per group)Dosage: 2 mg/kg, 1 mg/kg+15 mg/kg TEPP-46, 2 mg/kg+30 mg/kg TEPP-46 Administration: IP (100 µL), daily, for 3 weeks Result: Significantly lowered LDHA activity in plasma and tumor lysates; significantly lowered the expression of the proliferation marker Ki-67; significantly decreased proliferation indices were observed in tumor sections; significantly delayed tumor growth. Form:Solid IC50& Target:IC50: 23.3 μM (LDHA in HeLa cell)

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Naphthalenes
    - Subclass Naphthalenecarboxylic acids and derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Naphthalenes
Subclass	Naphthalenecarboxylic acids and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Naphthalenecarboxylic acids
Alternative Parents	Naphthols and derivatives Salicylic acid and derivatives Phenols Vinylogous acids Carboxylic acids Organooxygen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic homopolycyclic compounds
Substituents	1-naphthalenecarboxylic acid - 2-naphthol - Dihydroxybenzoic acid - Salicylic acid or derivatives - Hydroxybenzoic acid - Phenol - Monocyclic benzene moiety - Vinylogous acid - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Aromatic homopolycyclic compound
Description	This compound belongs to the class of organic compounds known as naphthalenecarboxylic acids. These are compounds containing a naphthalene moiety, which bears a carboxylic acid group one or more positions. Naphthalene is a bicyclic compound that is made up of two fused benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

LDHB Tchem L-lactate dehydrogenase B chain (3 Activities)

Discover Target: LDHB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LDHA Tchem L-lactate dehydrogenase A chain (2 Activities)

Discover Target: LDHA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LDHA Tchem L-lactate dehydrogenase A chain (1573 Activities)

Discover Target: LDHA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LDHB Tchem L-lactate dehydrogenase B chain (463 Activities)

Discover Target: LDHB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	7-benzyl-2,3-dihydroxy-6-methyl-4-propylnaphthalene-1-carboxylic acid
INCHI	InChI=1S/C22H22O4/c1-3-7-16-17-10-13(2)15(11-14-8-5-4-6-9-14)12-18(17)19(22(25)26)21(24)20(16)23/h4-6,8-10,12,23-24H,3,7,11H2,1-2H3,(H,25,26)
InChIKey	LVPYVYFMCKYFCZ-UHFFFAOYSA-N
Smiles	CCCC1=C(C(=C(C2=C1C=C(C(=C2)CC3=CC=CC=C3)C)C(=O)O)O)O
Isomeric SMILES	CCCC1=C(C(=C(C2=C1C=C(C(=C2)CC3=CC=CC=C3)C)C(=O)O)O)O
PubChem CID	10498042
Molecular Weight	350.41

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
D2422338	Certificate of Analysis	Apr 09, 2024	F650409
D2422339	Certificate of Analysis	Apr 09, 2024	F650409
D2422340	Certificate of Analysis	Apr 09, 2024	F650409
D2422353	Certificate of Analysis	Apr 09, 2024	F650409
D2422341	Certificate of Analysis	Apr 09, 2024	F650409

Chemical and Physical Properties

Solubility	DMSO : 250 mg/mL (713.45 mM; Need ultrasonic)
Molecular Weight	350.400 g/mol
XLogP3	6.200
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	5
Exact Mass	350.152 Da
Monoisotopic Mass	350.152 Da
Topological Polar Surface Area	77.800 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	473.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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