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Furamidine dihydrochloride - 98%, high purity , CAS No.55368-40-6

COA

Grade & Purity:

≥98%

Cas Number: 55368-40-6
Molecular Weight: 377.27
PubChem CID: 9799856

In stock

Item Number

F286803

Grouped product items
SKU	Size	Availability	Price	Qty
F286803-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$61.90
F286803-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$256.90

Selective PRMT1 inhibitor

View related series

Anti-infection (2803) Epigenetics (1496) Histone Methyltransferase (190) Histone Modification (1379) Metabolic Enzyme/Protease (4860) Nucleic Acid Metabolism (395) Parasite (997) Phosphodiesterase (PDE) (252)

Basic Description

Synonyms	DB 75 \| DB75 \| NSC 305831 \| WR199385 \| 4-[5-(4-carbamimidoylphenyl)furan-2-yl]benzenecarboximidamide;dihydrochloride \| DTXSID90970703 \| 4,4'-(Furan-2,5-diyl)dibenzimidamidedihydrochloride \| 4,4'-(2,5-Furandiyl)dibenzenecarboximidamide dihydrochloride \| 4,
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50= 9.4μM). Exhibits selectivity over PRMT5, PRMT6 and CARM1 (IC50values are 166, 283 and >400μM respectively). Inhibits cell proliferation in leukemia cell lines. Cell-permeable.
Storage Temp	Protected from light,Store at -20°C,Argon charged,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Furans
    - Subclass Diphenylfurans

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Furans
Subclass	Diphenylfurans
Intermediate Tree Nodes	Not available
Direct Parent	2,5-diphenylfurans
Alternative Parents	Benzene and substituted derivatives Heteroaromatic compounds Oxacyclic compounds Carboximidamides Carboxamidines Organopnictogen compounds Organooxygen compounds Organic chloride salts Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	2,5-diphenylfuran - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Amidine - Oxacycle - Carboximidamide - Carboxylic acid amidine - Organic chloride salt - Organic salt - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as 2,5-diphenylfurans. These are organic heterocyclic compounds that contain a furan ring substituted with a phenyl group only the C2- and C5-positions.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	4-[5-(4-carbamimidoylphenyl)furan-2-yl]benzenecarboximidamide;dihydrochloride
INCHI	InChI=1S/C18H16N4O.2ClH/c19-17(20)13-5-1-11(2-6-13)15-9-10-16(23-15)12-3-7-14(8-4-12)18(21)22;;/h1-10H,(H3,19,20)(H3,21,22);2*1H
InChIKey	VXNYQUQHOUERTR-UHFFFAOYSA-N
Smiles	C1=CC(=CC=C1C2=CC=C(O2)C3=CC=C(C=C3)C(=N)N)C(=N)N.Cl.Cl
Isomeric SMILES	C1=CC(=CC=C1C2=CC=C(O2)C3=CC=C(C=C3)C(=N)N)C(=N)N.Cl.Cl
PubChem CID	9799856
Molecular Weight	377.27

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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4 results found

Lot Number	Certificate Type	Date	Item
D2301303	Certificate of Analysis	Feb 03, 2023	F286803
D2301332	Certificate of Analysis	Feb 03, 2023	F286803
D2301301	Certificate of Analysis	Feb 03, 2023	F286803
C2528195	Certificate of Analysis	Feb 03, 2023	F286803

Chemical and Physical Properties

Solubility	Solvent:water, Max Conc. mg/mL: 18.86, Max Conc. mM: 50; Solvent:DMSO, Max Conc. mg/mL: 18.86, Max Conc. mM: 50
Sensitivity	light sensitive；Moisture sensitive
Molecular Weight	377.300 g/mol
XLogP3
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Exact Mass	376.086 Da
Monoisotopic Mass	376.086 Da
Topological Polar Surface Area	113.000 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	396.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	3

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