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Fumonisin B1 - ≥98% (HPLC), high purity , CAS No.116355-83-0

    Grade & Purity:
  • ≥98%(HPLC)
In stock
Item Number
F135527
Grouped product items
SKU Size
Availability
Price Qty
F135527-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$329.90
F135527-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,119.90

Protein serine/threonine phosphatase inhibitor. Cell proliferation inhibitor and apoptosis inducer

Basic Description

Synonyms HSDB 7077 | EX-A8017 | Fumonisin B1 50 microg/mL in Acetonitrile/Water | fumonisin-B1 | SCHEMBL13555629 | fumonisin b1 | fumonisin B(1) | UNII-3ZZM97XZ32 | AKOS024457430 | FUMONISIN B1 [IARC] | DTXSID6020644 | HY-N6719 | 1,2,3-PROPANETRICARBOXYLIC ACID, 1
Specifications & Purity ≥98%(HPLC)
Biochemical and Physiological Mechanisms Fungal metabolite believed to cause leukoencephalomalacia in horses.Mycotoxin and protein serine/threonine phosphatase inhibitor (IC 50 values are 80 μM (PP5), 0.3 (PP2Cα), 0.4 ( PP2A), 0.5 (PP1γ2) and 3 mM (PP2B)). Cell proliferation inhibitor and apopto
Storage Temp Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Fumonisin B1 is a fungal metabolite produced by Fusarium moniliforme, that has been shown to inhibit protein serine/threonine phosphatases (PP1, PP2A, PP2B, PP2C, and PP5/T/K/H), and is most effective with PP5. It has been shown to stimulate the activation of mitogen-activated protein kinase. Fumonisin B1 has been observed to inhibit sphingolipid biosynthesis, preferentially inhibiting sphingomyelin biosynthesis versus glycosphingolipids in neuronal cells. In primary rat liver cells, fumonisin B1 blocked biosynthesis of de novo sphingolipids through LASS (ceramide synthase) inhibition. Caspase-3 activated or DNA fragmented apoptosis induced by fumonisin B1 binding to a TNF receptor has been documented in many human and rat cell lines. Fumonisin B1 has displayed immunotoxic effects by increasing expression of IL-1β, TNFα, IFN-γ; (interferon γ), IL-1α, IL-6, IL-10, IL-18 and IL-12 in varying mouse cells. Immunotoxicity of fumonisin B1 in human dendritic cells has been demonstrated through expression of chemokine CXCL9 and IFN-γ. Further, fumonisin B1 is an activator of Akt.
A serine/threonine phosphatase inhibitor.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Fumonisins
Intermediate Tree Nodes Not available
Direct Parent Fumonisins
Alternative Parents Hexacarboxylic acids and derivatives  Fatty acid esters  Secondary alcohols  Carboxylic acid esters  Amino acids  1,2-aminoalcohols  Polyols  Carboxylic acids  Organopnictogen compounds  Organic oxides  Monoalkylamines  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aliphatic acyclic compounds
Substituents Fumonisin-skeleton - Fumonisin skeleton - Hexacarboxylic acid or derivatives - Fatty acid ester - Fatty acyl - 1,2-aminoalcohol - Amino acid or derivatives - Carboxylic acid ester - Secondary alcohol - Amino acid - Polyol - Carboxylic acid - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Primary amine - Amine - Organic oxide - Alcohol - Hydrocarbon derivative - Aliphatic acyclic compound
Description This compound belongs to the class of organic compounds known as fumonisins. These are diesters of propane-1,2,3-tricarboxylic acid (TCA) and similar long-chain aminopolyol backbones (for FB1: 2S-amino-12S,16R-dimethyl-3S,5R,10R,14S,15R-pentahydroxyeicosane). Structurally, fumonisins resemble the sphingoid bases sphinganine (SA) and sphingosine (SO) to which TCA groups have been added at the C-14 and C-15 positions.
External Descriptors Sphingoid base analogs

Names and Identifiers

IUPAC Name (2R)-2-[2-[(5R,6R,7S,9S,11R,16R,18S,19S)-19-amino-6-[(3R)-3,4-dicarboxybutanoyl]oxy-11,16,18-trihydroxy-5,9-dimethylicosan-7-yl]oxy-2-oxoethyl]butanedioic acid
INCHI InChI=1S/C34H59NO15/c1-5-6-9-20(3)32(50-31(44)17-23(34(47)48)15-29(41)42)27(49-30(43)16-22(33(45)46)14-28(39)40)13-19(2)12-24(36)10-7-8-11-25(37)18-26(38)21(4)35/h19-27,32,36-38H,5-18,35H2,1-4H3,(H,39,40)(H,41,42)(H,45,46)(H,47,48)/t19-,20+,21-,22+,23+,24+,25+,26-,27-,32+/m0/s1
InChIKey UVBUBMSSQKOIBE-DSLOAKGESA-N
Smiles CCCCC(C)C(C(CC(C)CC(CCCCC(CC(C(C)N)O)O)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O
Isomeric SMILES CCCC[C@@H](C)[C@H]([C@H](C[C@@H](C)C[C@@H](CCCC[C@H](C[C@@H]([C@H](C)N)O)O)O)OC(=O)C[C@@H](CC(=O)O)C(=O)O)OC(=O)C[C@@H](CC(=O)O)C(=O)O
WGK Germany 3
RTECS TZ8350000
Molecular Weight 721.83
Reaxy-Rn 7071407
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7071407&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number Certificate Type Date Item
F2511666 Certificate of Analysis May 22, 2025 F135527
J2408287 Certificate of Analysis Sep 19, 2024 F135527
I2209496 Certificate of Analysis Jun 17, 2024 F135527
E2423492 Certificate of Analysis May 14, 2024 F135527
L2115102 Certificate of Analysis Sep 19, 2023 F135527
D1720030 Certificate of Analysis Nov 15, 2022 F135527
I2209493 Certificate of Analysis Jun 18, 2022 F135527

Chemical and Physical Properties

Solubility Soluble in water (25 mg/mL), methanol (10 mg/mL), acetonitrile, and DMSO (10 mM).
Sensitivity Moisture & Light sensitive
Molecular Weight 721.800 g/mol
XLogP3 -0.500
Hydrogen Bond Donor Count 8
Hydrogen Bond Acceptor Count 16
Rotatable Bond Count 31
Exact Mass 721.388 Da
Monoisotopic Mass 721.388 Da
Topological Polar Surface Area 289.000 Ų
Heavy Atom Count 50
Formal Charge 0
Complexity 1070.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 10
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

1. Defeng Wen, Wantong Han, Quan Chen, Guanhui Qi, Mengling Gao, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Qirong Lu, Yinsheng Qiu.  (2024)  Integrating network pharmacology and experimental validation to explore the mechanisms of luteolin in alleviating fumonisin B1–induced intestinal inflammatory injury.  TOXICON,  237  (107531). 
2. Ya-Hui Yu, Xin-Huai Zhao.  (2023)  Longan Polysaccharides with Covalent Selenylation Combat the Fumonisin B1-Induced Cell Toxicity and Barrier Disruption in Intestinal Epithelial (IEC-6) Cells.  Nutrients,  15  (21): (4679). 
3. Peifang Chen, Caiyun Jiang, Zhouping Wang, Hong-zhen Lian, Xiaoyuan Ma.  (2023)  3D plasmonic SERS aptasensor for rapid detection of aflatoxin B1 combined with Au@Ag bimetallic nanostars and Fe3O4@MoS2 magnetic nanoflowers.  MICROCHEMICAL JOURNAL,    (109598). 
4. Ting Wang, Jie Cheng, Jinmao You, Zhiwei Sun.  (2023)  Highly selective and sensitive high performance liquid chromatography method for determination of fumonisins from feed samples with MIL-101 based dispersed micro-solid-phase extraction and precolumn fluorescence derivatization.  MICROCHEMICAL JOURNAL,  194  (109320). 
5. Guo Ge, Tianlin Wang, Zihou Liu, Xiaomeng Liu, Tiange Li, Yuntang Chen, Jialin Fan, Erkigul Bukye, Xianqing Huang, Lianjun Song.  (2023)  A self-assembled DNA double-crossover-based fluorescent aptasensor for highly sensitivity and selectivity in the simultaneous detection of aflatoxin M1 and aflatoxin B1.  TALANTA,  265  (124908). 
6. Zhang Hong, Wang Yuli, Lin Yingtong, Chu Wenjuan, Luo Zhen, Zhao Mingqin, Hu Jiandong, Miao Xiangmin, He Fan.  (2023)  A catalytic hairpin assembly–based Förster resonance energy transfer sensor for ratiometric detection of ochratoxin A in food samples.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  415  (5): (867-874). 
7. Zhu Jing, Xu Wenxing, Yang Ye, Kong Rongmei, Wang Junmei.  (2023)  ssDNA-C3N4 conjugates-based nanozyme sensor array for discriminating mycotoxins.  MICROCHIMICA ACTA,  190  (1): (1-10). 
8. Pengfei Wang, Bin Luo, Ke Liu, Cheng Wang, Hongtu Dong, Xiaodong Wang, Peichen Hou, Aixue Li.  (2022)  A novel COOH–GO–COOH–MWNT/pDA/AuNPs based electrochemical aptasensor for detection of AFB1.  RSC Advances,  12  (43): (27940-27947). 
9. Kezhuo Zhang, Huadong Cai, Min Lu, Daixian Wei, Jiaqi Yin, Nengshui Ding, Weihua Lai, Juan Peng.  (2022)  Quantum dot nanobead immunochromatographic assay based on bispecific monoclonal antibody for the simultaneous detection of aflatoxin B1 and amantadine.  FOOD AND AGRICULTURAL IMMUNOLOGY,  33  (1): (403-418). 
10. Mei Liu, Jinxin Zhang, Shasha Liu, Baoxin Li.  (2022)  A label-free visual aptasensor for zearalenone detection based on target-responsive aptamer-cross-linked hydrogel and color change of gold nanoparticles.  FOOD CHEMISTRY,  389  (133078). 
11. Fan Jia, Yuye Li, Qingfa Gong, Dong Liu, Shuyun Meng, Chengxi Zhu, Tianyan You.  (2022)  A Simple Ratiometric Electrochemical Aptasensor Based on the Thionine–Graphene Nanocomposite for Ultrasensitive Detection of Aflatoxin B2 in Peanut and Peanut Oil.  Chemosensors,  10  (5): (154). 
12. Ting Chen, Yuye Li, Shuyun Meng, Chang Liu, Dong Liu, Daming Dong, Tianyan You.  (2022)  Temperature and pH tolerance ratiometric aptasensor: Efficiently self-calibrating electrochemical detection of aflatoxin B1.  TALANTA,  242  (123280). 
13. Chengxi Zhu, Dong Liu, Yuye Li, Ting Chen, Tianyan You.  (2022)  Label-free ratiometric homogeneous electrochemical aptasensor based on hybridization chain reaction for facile and rapid detection of aflatoxin B1 in cereal crops.  FOOD CHEMISTRY,  373  (131443). 
14. Xiaoyuan Ma, Baoyi Shao, Zhouping Wang.  (2021)  Gold@silver nanodumbbell based inter-nanogap aptasensor for the surface enhanced Raman spectroscopy determination of ochratoxin A.  ANALYTICA CHIMICA ACTA,  1188  (339189). 
15. Xiaoya Bi, Lijun Luo, Libo Li, Xiaohong Liu, Bainian Chen, Tianyan You.  (2020)  A FRET-based aptasensor for ochratoxin A detection using graphitic carbon nitride quantum dots and CoOOH nanosheets as donor-acceptor pair.  TALANTA,  218  (121159). 
16. Yuye Li, Dong Liu, Chengxi Zhu, Xiuli Shen, Yang Liu, Tianyan You.  (2020)  Sensitivity programmable ratiometric electrochemical aptasensor based on signal engineering for the detection of aflatoxin B1 in peanut.  JOURNAL OF HAZARDOUS MATERIALS,  387  (122001). 
17. He Deyun, Wu Zhengzong, Cui Bo, Xu Enbo, Jin Zhengyu.  (2019)  Building a Fluorescent Aptasensor Based on Exonuclease-Assisted Target Recycling Strategy for One-Step Detection of T-2 Toxin.  Food Analytical Methods,  12  (2): (625-632). 
18. Zhengzong Wu, Enbo Xu, Muhammad F.J. Chughtai, Zhengyu Jin, Joseph Irudayaraj.  (2017)  Highly sensitive fluorescence sensing of zearalenone using a novel aptasensor based on upconverting nanoparticles.  FOOD CHEMISTRY,  230  (673). 
19. Xuejuan Chen, Xiaojing Bai, Huiyan Li, Bailin Zhang.  (2015)  Aptamer-based microcantilever array biosensor for detection of fumonisin B-1.  RSC Advances,  (45): (35448-35452). 
20. Tiange Li, Ge Guo, Meijun Lu, Puye Liang, Yan Ma, Lianjun Song, Xianqing Huang, Jiansheng Zhao, Tianlin Wang.  (2025)  A fluorescence and colorimetric dual-mode sensor based on the aptamer-adsorbed hollow cerium oxide for sensitive and visual detection of Aflatoxin B1 in food.  MICROCHEMICAL JOURNAL,  208  (112387). 
21. Yuzheng CAI, Ge GUO, Yankun FU, Xianqing HUANG, Tianlin WANG, Tiange LI.  (2024)  A fluorescent aptasensor based on functional graphene oxide and FRET strategy simultaneously detects aflatoxins B1 and aflatoxins M1.  CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,  52  (100408). 
22. Qiaoning Dang, Bolu Sun, Hongxia Shi, Quhuan Ma, Yuhong Liu, Haoye Zou, Xinlan Wang, Xuanxiu Da, Miao Zhou, Ying Lv, Lin Yang, Xiaofeng Shi.  (2024)  A Highly Sensitive and Rapid Enzyme Biosensor Based on AuNPs/CS@cMWCNTS for Detecting Fusarium Acid.  JOURNAL OF THE ELECTROCHEMICAL SOCIETY,  171  (8): (087521). 
23. Wang Yutong, Liang Xiao, Yang Yaling.  (2025)  A SERS “on–off” sensor for Hg2+ and fumonisin B1 determination in grains based on Au-Janus Ag NPs modified by carbon dots.  MICROCHIMICA ACTA,  192  (3): (1-13). 
24. Yingao Yang, Ruipeng Chen, Yifen Guo, Jiaxin Zhang, Shuyue Ren, Huanying Zhou, Zhixian Gao.  (2025)  A two-color fluorescence sensing strategy based on functionalized tetrahedral DNAzyme nanotweezers for ochratoxin A detection.  TALANTA,  285  (127348). 
25. Lakshani Madushika, Yongming Huang, Menghan Sun, Yuxuan Liu, Linfang Lu, Xiaoli Li, Na Li, Kang Jiang, Sumei Ling, Shihua Wang.  (2025)  Development of sensitive and rapid immunoassays for Moniliformin (MON) detection based on nanomaterials labeled monoclonal antibodies.  FOOD CHEMISTRY,    (142911). 
26. Xiaopeng Hu, Ke Wang, Yufan Yang, Baomiao Ding, Chunqi Yu.  (2025)  Fluorescence/colorimetric sensor based on aptamers-molecular imprinted polymers synergistic recognition for ultrasensitive and interference-free detection of aflatoxin B1.  FOOD CHEMISTRY,  467  (142387). 
27. Liao Song, Gui Liuyang, Yang Yufan, Liu Yiwei, Hu Xiaopeng.  (2024)  Fluorescence/visual aptasensor based on Au/MOF nanocomposite for accurate and convenient aflatoxin B1 detection.  MICROCHIMICA ACTA,  191  (8): (1-10). 
28. Hongcheng Gao, Zhenzhen Xie, Shihao Xu, Changlong Jiang.  (2025)  MUA-modified Au nanocluster-driven fluorescence sensor for chromatographic test strips-based visual detection of patulin.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,    (125736). 
29. Hui-Ling Wu, Jing Chen, Fei Pan, Qi-Sheng Xia, Shi-Wei Zhang, Xue-Jian Chen, Rong-Hu Feng, Gui-Hong Zhang, Lei Liu, Xin-Tian Lai, Pan Tan.  (2024)  Screening for Bongkrekic Acid in Food Using a Monoclonal Antibody-Based Indirect Competitive Enzyme-Linked Immunosorbent Assay (icELISA).  ANALYTICAL LETTERS,     
30. Lianjun Song, Meijun Lu, Puye Liang, Tiange Li, Xianqing Huang, Yan Ma, Libin Wan, Tianlin Wang.  (2024)  Smartphone-assisted ratiometric FRET aptasensor based on quantum dots and gold nanoparticles for point-of-care testing of zearalenone in cereals.  FOOD CONTROL,  165  (110666). 
31. Jun Ma, Ruixue Huang, Huai Zhang, Dongju Liu, Xiaodong Dong, Yan Xiong, Xianrong Xiong, Daoliang Lan, Wei Fu, Honghong He, Jian Li, Shi Yin.  (2024)  The Protective Effect of Quercetin against the Cytotoxicity Induced by Fumonisin B1 in Sertoli Cells.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  25  (16): (8764). 

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