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Fosamprenavir Calcium Salt - 10mM in DMSO, high purity , CAS No.226700-81-8, Human immunodeficiency virus type 1 protease inhibitor
a water soluble protease inhibitor
Basic Description
Synonyms
Fosamprenavir calcium | 226700-81-8 | Fosamprenavir Calcium Salt | Lexiva | Telzir | Amprenavir phosphate calcium | Fosamprenavir (Calcium Salt) | Fosamprenavir calcium [USAN] | GW433908G | UNII-ID1GU2627N | GW 433908G | GW-433908G | ID1GU2627N | DTXSID0046777 | DTXCID8026777 | ((3S)O
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Fosamprenavir calcium is an HIV protease inhibitor anti-retroviral. It is a water soluble phosphate ester prodrug of amprenavir, the active agent.
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Mechanism of action
Human immunodeficiency virus type 1 protease inhibitor
Product Description
Fosamprenavir Calcium Salt is a HIV protease inhibitor that is water soluble prodrug of amprenavir.
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Benzenoids
Class
Benzene and substituted derivatives
Subclass
Benzenesulfonamides
Intermediate Tree Nodes
Not available
Direct Parent
Aminobenzenesulfonamides
Alternative Parents
Phenylbutylamines Amphetamines and derivatives Benzenesulfonyl compounds Phosphoethanolamines Aniline and substituted anilines Alkyl phosphates Organosulfonamides Tetrahydrofurans Aminosulfonyl compounds Carbamate esters Organic carbonic acids and derivatives Dialkyl ethers Oxacyclic compounds Organic calcium salts Hydrocarbon derivatives Carbonyl compounds Primary amines Organic oxides Organic zwitterions Organopnictogen compounds
Molecular Framework
Aromatic heteromonocyclic compounds
Substituents
Aminobenzenesulfonamide - Phenylbutylamine - Amphetamine or derivatives - Benzenesulfonyl group - Phosphoethanolamine - Aniline or substituted anilines - Organic phosphoric acid derivative - Phosphoric acid ester - Organosulfonic acid amide - Alkyl phosphate - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Aminosulfonyl compound - Carbamic acid ester - Tetrahydrofuran - Sulfonyl - Carbonic acid derivative - Oxacycle - Organoheterocyclic compound - Dialkyl ether - Ether - Organic calcium salt - Organic nitrogen compound - Organopnictogen compound - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Amine - Organic salt - Hydrocarbon derivative - Organic oxide - Carbonyl group - Primary amine - Organic zwitterion - Organic oxygen compound - Aromatic heteromonocyclic compound
Description
This compound belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
External Descriptors
Not available
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
IUPAC Name
calcium;[(2R,3S)-1-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-[[(3S)-oxolan-3-yl]oxycarbonylamino]-4-phenylbutan-2-yl] phosphate
INCHI
InChI=1S/C25H36N3O9PS.Ca/c1-18(2)15-28(39(33,34)22-10-8-20(26)9-11-22)16-24(37-38(30,31)32)23(14-19-6-4-3-5-7-19)27-25(29)36-21-12-13-35-17-21;/h3-11,18,21,23-24H,12-17,26H2,1-2H3,(H,27,29)(H2,30,31,32);/q;+2/p-2/t21-,23-,24+;/m0./s1
InChIKey
PMDQGYMGQKTCSX-HQROKSDRSA-L
Smiles
CC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)OC2CCOC2)OP(=O)([O-])[O-])S(=O)(=O)C3=CC=C(C=C3)N.[Ca+2]
Isomeric SMILES
CC(C)CN(C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)O[C@H]2CCOC2)OP(=O)([O-])[O-])S(=O)(=O)C3=CC=C(C=C3)N.[Ca+2]
RTECS
EY8573300
PubChem CID
131535
Molecular Weight
623.67
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Refractive Index
n20D1.61 (Predicted)
Melt Point(°C)
>257° C (dec.)
Molecular Weight
623.700 g/mol
XLogP3
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
11
Rotatable Bond Count
13
Exact Mass
623.138 Da
Monoisotopic Mass
623.138 Da
Topological Polar Surface Area
192.000 Ų
Heavy Atom Count
40
Formal Charge
0
Complexity
901.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
3
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
2
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