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FLLL32 - 98%, high purity , CAS No.1226895-15-3

COA

Grade & Purity:

≥98%

Cas Number: 1226895-15-3
Molecular Weight: 464.55
PubChem CID: 68019246
PubChem SID: 488202113

In stock

Item Number

F413726

Grouped product items
SKU	Size	Availability	Price
F413726-5mg	5mg	3	$75.90
F413726-25mg	25mg	2	$162.90
F413726-50mg	50mg	1	$271.90
F413726-100mg	100mg	1	$489.90

JAK2 Selective Inhibitors

View related series

Apoptosis (4276) Epigenetics (1496) Histone Modification (1379) JAK (149) JAK/STAT Signaling (507) Non-receptor Tyrosine Kinase (643) Protein Tyrosine Kinase/RTK (1314) STAT (139) Stem Cell/Wnt (1019)

Basic Description

Synonyms	(2E,2'E)-1,1'-cyclohexylidenebis[3-(3,4-dimethoxyphenyl)-2-propen-1-one
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of <5 μM. FLLL32 inhibits the induction of STAT3 phosphorylation by IFNα and IL-6 in breast cancer cells.
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information FLLL32 is a potentJAK2/STAT3inhibitor withIC50of <5 μM. FLLL32 inhibits the induction of STAT3 phosphorylation byIFNαandIL-6in breast cancer cells. Targets JAK2 <5 μM In vitro In MDA-MB-231 breast and PANC-1 pancreatic cancer cells, FLLL32 downregulates STAT3 phosphorylation and DNA-binding activity. In MDA-MB-231 cells, FLLL32 inhibit the formation of colonies and cell invasion. In human multiple myeloma, glioblastoma, liver cancer, and colorectal cancer cell lines, FLLL32 also leads to the inhibition of cell proliferation and the induction of caspase-3 and PARP cleavages. In vivo In MDA-MB-231 xenografted mice, FLLL32 (50 mg/kg, i.p.) significantly reduces tumor burdens. In mouse xenografts with OS-33 osteosarcoma cells, FLLL32 (50 mg/kg, i.p.) also inhibits tumor growth by targeting STAT3. Cell Research(from reference) Cell lines：MDA-MB-231 cell line Concentrations：~5 μM Incubation Time：72 hours

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class Diarylheptanoids
    - Subclass Linear diarylheptanoids

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Diarylheptanoids
Subclass	Linear diarylheptanoids
Intermediate Tree Nodes	Not available
Direct Parent	Curcuminoids
Alternative Parents	Cinnamic acids and derivatives Dimethoxybenzenes Styrenes Phenoxy compounds Anisoles Alkyl aryl ethers Enones Acryloyl compounds Ketones Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Curcumin - Cinnamic acid or derivatives - O-dimethoxybenzene - Dimethoxybenzene - Phenoxy compound - Anisole - Methoxybenzene - Phenol ether - Styrene - Alkyl aryl ether - Monocyclic benzene moiety - Benzenoid - Enone - Acryloyl-group - Alpha,beta-unsaturated ketone - Ketone - Ether - Organic oxygen compound - Carbonyl group - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as curcuminoids. These are aromatic compounds containing a curcumin moiety, which is composed of two aryl buten-2-one (feruloyl) chromophores joined by a methylene group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488202113
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488202113
IUPAC Name	(E)-3-(3,4-dimethoxyphenyl)-1-[1-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]cyclohexyl]prop-2-en-1-one
INCHI	InChI=1S/C28H32O6/c1-31-22-12-8-20(18-24(22)33-3)10-14-26(29)28(16-6-5-7-17-28)27(30)15-11-21-9-13-23(32-2)25(19-21)34-4/h8-15,18-19H,5-7,16-17H2,1-4H3/b14-10+,15-11+
InChIKey	NQDROBVIYYEMDQ-WFYKWJGLSA-N
Smiles	COC1=C(C=C(C=C1)C=CC(=O)C2(CCCCC2)C(=O)C=CC3=CC(=C(C=C3)OC)OC)OC
Isomeric SMILES	COC1=C(C=C(C=C1)/C=C/C(=O)C2(CCCCC2)C(=O)/C=C/C3=CC(=C(C=C3)OC)OC)OC
Molecular Weight	464.55
Reaxy-Rn	56619736
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=56619736&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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9 results found

Lot Number	Certificate Type	Date	Item
C2526162	Certificate of Analysis	Apr 14, 2025	F413726
C2328645	Certificate of Analysis	Jan 20, 2025	F413726
C2328528	Certificate of Analysis	Jan 20, 2025	F413726
C2328686	Certificate of Analysis	Jan 20, 2025	F413726
C2328654	Certificate of Analysis	Jan 20, 2025	F413726
C2328717	Certificate of Analysis	Jan 20, 2025	F413726
C2328671	Certificate of Analysis	Jan 20, 2025	F413726
C2328751	Certificate of Analysis	Jan 20, 2025	F413726
C2328677	Certificate of Analysis	Jan 20, 2025	F413726

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 92 mg/mL (198.04 mM); Ethanol: 25 mg/mL warmed with 50ºC Water: bath (53.81 mM); Water: Insoluble;
Sensitivity	Light sensitive
Molecular Weight	464.500 g/mol
XLogP3	5.800
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	10
Exact Mass	464.22 Da
Monoisotopic Mass	464.22 Da
Topological Polar Surface Area	71.100 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	668.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	2
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	2
Covalently-Bonded Unit Count	1

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