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Fisogatinib (BLU-554) - 98%, high purity , CAS No.1707289-21-1, Inhibitor of fibroblast growth factor receptor 4

COA COA
In stock
Item Number
F414033
Grouped product items
SKU Size
Availability
 Price Qty
F414033-1mg
1mg
3
$35.90
F414033-5mg
5mg
3
$147.90
F414033-10mg
10mg
3
$246.90
F414033-25mg
25mg
3
$555.90
F414033-50mg
50mg
2
$741.90
F414033-100mg
100mg
2
$1,286.90
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FGFR Inhibitors

View related series
FGFR (112) fibroblast growth factor receptor 4 Inhibitor (16) Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260)

Basic Description

Synonyms AC-29871 | AS-55934 | BB160379 | BDBM50575072 | BLU554 | BLU-554 | 4-Hydroxy-8-methoxyquinoline-3-carboxylic acid ethyl ester, AldrichCPR | GTPL10220 | InChI=1/C13H10O3/c14-12-7-5-10(6-8-12)9-1-3-11(4-2-9)13(15)16/h1-8,14H,(H,15,16 | M0986 | N-[(3S,4S)-3-
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms Fisogatinib (BLU-554) is a potent, highly-selective, oral FGFR4 inhibitor with an IC50 value of 5 nM. The IC50s for FGFR1-3 is 624-2203 nM.
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of fibroblast growth factor receptor 4
Product Description

Information

Fisogatinib (BLU-554) Fisogatinib (BLU-554) is a potent, highly-selective, oral FGFR4 inhibitor with an IC50 value of 5 nM. The IC50s for FGFR1-3 is 624-2203 nM.


Targets

FGFR4 (Cell-free assay) 5 nM


In vitro

BLU-554 exploits a unique interaction with FGFR4 to confer potency and selectivity


In vivo

BLU-554 is well tolerated in these tumor models. Administration of BLU-554 induces tumor regression in liver cancer models.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Diazanaphthalenes
Subclass Benzodiazines
Intermediate Tree Nodes Quinazolines
Direct Parent Quinazolinamines
Alternative Parents Dimethoxybenzenes  Anisoles  Dichlorobenzenes  Phenoxy compounds  Alkyl aryl ethers  Aminopyrimidines and derivatives  Aryl chlorides  Oxanes  Heteroaromatic compounds  Acrylic acids and derivatives  Secondary carboxylic acid amides  Dialkyl ethers  Azacyclic compounds  Oxacyclic compounds  Organochlorides  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  Amines  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Quinazolinamine - Dimethoxybenzene - M-dimethoxybenzene - 1,3-dichlorobenzene - Phenol ether - Phenoxy compound - Methoxybenzene - Anisole - Halobenzene - Aminopyrimidine - Chlorobenzene - Alkyl aryl ether - Monocyclic benzene moiety - Oxane - Benzenoid - Aryl halide - Aryl chloride - Pyrimidine - Heteroaromatic compound - Acrylic acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Ether - Dialkyl ether - Carboxylic acid derivative - Azacycle - Oxacycle - Organonitrogen compound - Organooxygen compound - Amine - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organohalogen compound - Organochloride - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as quinazolinamines. These are heterocyclic aromatic compounds containing a quianazoline moiety substituted by one or more amine groups.
External Descriptors Not available

Product Properties

ALogP 4.229
hba_count 6
HBD Count 2
Rotatable Bond 7

Associated Targets(Human)

FGFR4 Tclin Fibroblast growth factor receptor 4 (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
KCNH2 Tclin HERG (29587 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C8 Tchem Cytochrome P450 2C8 (1492 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FGFR2 Tclin Fibroblast growth factor receptor 2 (3405 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FGFR1 Tclin Fibroblast growth factor receptor 1 (9149 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2B6 Tchem Cytochrome P450 2B6 (1338 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Huh-7 (12904 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RT-112 (346 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SNU-16 (476 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H1581 (382 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Fgfr4 Fibroblast growth factor receptor 4 (138 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BaF3 (4657 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504772691
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504772691
IUPAC Name N-[(3S,4S)-3-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]oxan-4-yl]prop-2-enamide
INCHI InChI=1S/C24H24Cl2N4O4/c1-4-20(31)28-16-7-8-34-12-17(16)30-24-27-11-14-9-13(5-6-15(14)29-24)21-22(25)18(32-2)10-19(33-3)23(21)26/h4-6,9-11,16-17H,1,7-8,12H2,2-3H3,(H,28,31)(H,27,29,30)/t16-,17+/m0/s1
InChIKey MGZKYOAQVGSSGC-DLBZAZTESA-N
Smiles COC1=CC(=C(C(=C1Cl)C2=CC3=CN=C(N=C3C=C2)NC4COCCC4NC(=O)C=C)Cl)OC
Isomeric SMILES COC1=CC(=C(C(=C1Cl)C2=CC3=CN=C(N=C3C=C2)N[C@@H]4COCC[C@@H]4NC(=O)C=C)Cl)OC
Molecular Weight 503.38
Reaxy-Rn 36627380
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=36627380&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number Certificate Type Date Item
K2218433 Certificate of Analysis Aug 25, 2022 F414033
K2218590 Certificate of Analysis Aug 25, 2022 F414033
K2218591 Certificate of Analysis Aug 25, 2022 F414033
K2218470 Certificate of Analysis Aug 25, 2022 F414033
K2218434 Certificate of Analysis Aug 25, 2022 F414033
K2218448 Certificate of Analysis Aug 25, 2022 F414033

Chemical and Physical Properties

Solubility Solubility (25°C) In vitro DMSO: 100 mg/mL warmed with 50ºC Water: bath (198.65 mM); Ethanol: 2 mg/mL warmed with 50ºC Water: bath (3.97 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility 100
DMSO(mM) Max Solubility 198.6570782
Water(mg / mL) Max Solubility ＜1
Molecular Weight 503.400 g/mol
XLogP3 4.700
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 7
Exact Mass 502.117 Da
Monoisotopic Mass 502.117 Da
Topological Polar Surface Area 94.600 Ų
Heavy Atom Count 34
Formal Charge 0
Complexity 688.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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