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Fasudil Hydrochloride - 98%, high purity , CAS No.105628-07-7

1 Citations COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
F122336
Grouped product items
SKU Size
Availability
 Price Qty
F122336-100mg
100mg
3
$37.90
F122336-250mg
250mg
3
$78.90
F122336-500mg
500mg
3
$129.90
F122336-1g
1g
3
$234.90
F122336-5g
5g
3
$1,053.90
F122336-25g
25g
2
$4,738.90
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Bulk Order  SDS  DATASHEET  Specification Sheet

Inhibitor of cyclic nucleotide dependent- and Rho-kinases

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Basic Description

Synonyms 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride | 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline hydrochloride | 111GE018 | AKOS015897321 | Fasudil HCl - HA-1077 | FT-0631034 | EN300-7361975 | BCP26351 | s1573 | REGID_for_CID_4917 | 5-(1-Homopiperazi
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50= 10.7μM). Suppress MMP-2 expression and induce apoptosis in glioblastoma cellsin vivo. Ca2+antagonist and vasodilator. Also inhibits proliferation of vascular s
Storage Temp Protected from light,Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Fasudil, Monohydrochloride Salt is a cell-permeable, selective ROCK inhibitor which induces neuroprotection in vitro. Studies suggest that when acting as a ROCK inhibitor, Fasudil reduces neutrophil transendothelial migration by diminishing cytoskeletal rearrangement of endothelial cells. In addition, Fasudil significantly protects against MeHg-induced axonal degeneration and apoptotic cell death in cultured cortical neurons. Alternate studies show that Fasudil plays an important role in osteoblastic differentiation of stromal cells via increasing the mRNA expression of collagen-I, osteocalcin, and bone morphogenetic protein-2 (BMP-2). Furthermore, noggin, a BMP-2 antagonist can reverse the effects of Fasudil induced mRNA expression of collagen-I and osteocalcin. Upon inhibition of Rho-kinase, Fasudil significantly stimulates FGF-2-induced accumulation of vascular endothelial growth factor (VEGF). Fasudil, Monohydrochloride Salt is an inhibitor of cGKI, MSK1, PKA, PRK2, Rock-2, AMPK, CaMKII, Polycystin-1 and Rsk-1.
A selective ROCK inhibitor

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Isoquinolines and derivatives
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Isoquinolines and derivatives
Alternative Parents 1,4-diazepanes  Pyridines and derivatives  Organosulfonamides  Benzenoids  Sulfonyls  Heteroaromatic compounds  Dialkylamines  Azacyclic compounds  Organopnictogen compounds  Organic oxides  Hydrochlorides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Isoquinoline - 1,4-diazepane - Diazepane - Pyridine - Organosulfonic acid amide - Benzenoid - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Sulfonyl - Heteroaromatic compound - Secondary amine - Secondary aliphatic amine - Azacycle - Hydrocarbon derivative - Amine - Organic nitrogen compound - Organic oxide - Organosulfur compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Hydrochloride - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as isoquinolines and derivatives. These are aromatic polycyclic compounds containing an isoquinoline moiety, which consists of a benzene ring fused to a pyridine ring and forming benzo[c]pyridine.
External Descriptors Not available

Associated Targets(Human)

CCR2 Tchem C-C chemokine receptor type 2 (5628 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTT Tchem Huntingtin (19182 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ROCK2 Tclin Rho-associated protein kinase (137 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Galc Galactocerebrosidase (11 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504757540
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504757540
IUPAC Name 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;hydrochloride
INCHI InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H
InChIKey LFVPBERIVUNMGV-UHFFFAOYSA-N
Smiles C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl
Isomeric SMILES C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl
WGK Germany 1
RTECS HM4033500
Alternate CAS 203911-27-7
Molecular Weight 327.83
Reaxy-Rn 5466340
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5466340&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number Certificate Type Date Item
I2130277 Certificate of Analysis Jul 10, 2025 F122336
J2106184 Certificate of Analysis Jul 10, 2025 F122336
J2106185 Certificate of Analysis Jul 10, 2025 F122336
A1710017 Certificate of Analysis Sep 10, 2024 F122336
I2222036 Certificate of Analysis Aug 10, 2022 F122336
I2221378 Certificate of Analysis Aug 10, 2022 F122336
I2222046 Certificate of Analysis Aug 10, 2022 F122336
I2222047 Certificate of Analysis Aug 10, 2022 F122336
I2222048 Certificate of Analysis Aug 10, 2022 F122336
I2222052 Certificate of Analysis Aug 10, 2022 F122336

Chemical and Physical Properties

Solubility Solvent:water, Max Conc. mg/mL: 32.78, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 24.59, Max Conc. mM: 75
Sensitivity light sensitive
Refractive Index 1.62
Boil Point(°C) 506.2° C
Melt Point(°C) 222 °C
Molecular Weight 327.800 g/mol
XLogP3
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 2
Exact Mass 327.081 Da
Monoisotopic Mass 327.081 Da
Topological Polar Surface Area 70.700 Ų
Heavy Atom Count 21
Formal Charge 0
Complexity 421.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Chen Wenyuanfeng, Qu Yuan, Liu Yining, Zhang Guorui, Sharhan Hasan M., Zhang Xinzhu, Zhang Kunwu, Cao Baocheng.  (2024)  Effects of fasudil on glial cell activation induced by tooth movement.  Progress in Orthodontics,  25  (1): (1-13). 

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