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Fananserin - ≥99%(HPLC), high purity , CAS No.127625-29-0, Antagonist of 5-HT 2A receptor

COA

Grade & Purity:

Moligand™

≥99%(HPLC)

Cas Number: 127625-29-0
Molecular Weight: 425.52
PubChem CID: 60785
PubChem SID: 504753716

In stock

Item Number

F288498

Grouped product items
SKU	Size	Availability	Price
F288498-5mg	5mg	3	$185.90
F288498-10mg	10mg	3	$315.90
F288498-25mg	25mg	2	$711.90
F288498-50mg	50mg	2	$1,038.90
F288498-100mg	100mg	2	$1,711.90

5-HT2Aantagonist; also D4antagonist

View related series

5-HT Receptor (264) 5-HT2A receptor Antagonist (83) Class A GPCR (4138) Dopamine Receptor (237) GPCR/G Protein (3172) Neuronal Signaling (3320)

Basic Description

Synonyms	2H-Naphth[1,8-cd]isothiazole, 2-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-, 1,1-dioxide \| Tox21 112587 \| 3-[3-[4-(4-fluorophenyl)piperazin-1-yl]propyl]-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaene 2,2-dioxide \| HMS3413N09 \|
Specifications & Purity	Moligand™, ≥99%(HPLC)
Biochemical and Physiological Mechanisms	5-HT2Areceptor antagonist that also displays high affinity at D4receptors (Kivalues are 0.26, 2.93, 25, 38, 70 and 726 nM for 5-HT2A, D4, H1,α1, 5-HT1Aand D2receptors respectively). Inhibits inositol phosphate formation evoked by 5-HTin vitro(IC50= 7.76 n
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of 5-HT 2A receptor

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Naphthalenes
    - Subclass Naphthalene sulfonic acids and derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Naphthalenes
Subclass	Naphthalene sulfonic acids and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	1-naphthalene sulfonic acids and derivatives
Alternative Parents	1-naphthalene sulfonamides Phenylpiperazines N-arylpiperazines Benzothiazoles Aniline and substituted anilines Dialkylarylamines Fluorobenzenes N-alkylpiperazines Aryl fluorides Organosulfonamides Trialkylamines Azacyclic compounds Hydrocarbon derivatives Organofluorides Organopnictogen compounds Organic oxides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	1-naphthalene sulfonamide - Naphthalene sulfonamide - 1-naphthalene sulfonic acid or derivatives - Phenylpiperazine - N-arylpiperazine - 1,2-benzothiazole - Tertiary aliphatic/aromatic amine - Aniline or substituted anilines - Dialkylarylamine - Fluorobenzene - Halobenzene - N-alkylpiperazine - Aryl fluoride - Organosulfonic acid amide - Piperazine - Aryl halide - Monocyclic benzene moiety - 1,4-diazinane - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Tertiary aliphatic amine - Tertiary amine - Organoheterocyclic compound - Azacycle - Organic oxide - Organohalogen compound - Amine - Organofluoride - Organic nitrogen compound - Organonitrogen compound - Organic oxygen compound - Hydrocarbon derivative - Organopnictogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as 1-naphthalene sulfonic acids and derivatives. These are organic aromatic compounds that contain a naphthalene moiety that carries a sulfonic acid group (or a derivative thereof) at the 1-position. Naphthalene is a bicyclic compound that is made up of two fused benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

DRD4 Tchem D(4) dopamine receptor (2 Activities)

Discover Target: DRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2A Tclin 5-hydroxytryptamine receptor 2A (4 Activities)

Discover Target: HTR2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2C Tclin 5-hydroxytryptamine receptor 2C (1 Activities)

Discover Target: HTR2C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (2 Activities)

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	504753716
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504753716
IUPAC Name	3-[3-[4-(4-fluorophenyl)piperazin-1-yl]propyl]-2λ6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaene 2,2-dioxide
INCHI	InChI=1S/C23H24FN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2
InChIKey	VGIGHGMPMUCLIQ-UHFFFAOYSA-N
Smiles	C1CN(CCN1CCCN2C3=CC=CC4=C3C(=CC=C4)S2(=O)=O)C5=CC=C(C=C5)F
Isomeric SMILES	C1CN(CCN1CCCN2C3=CC=CC4=C3C(=CC=C4)S2(=O)=O)C5=CC=C(C=C5)F
Alternate CAS	127625-29-0
MeSH Entry Terms	2-(3-(4-(4-fluorophenyl)-1-piperazinyl)propyl)-2H-naphth(1,8-cd)isothiazole 1,1-dioxide;fananserin;fananserine;RP 62203;RP-62203
Molecular Weight	425.52
Reaxy-Rn	4769415
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4769415&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number	Certificate Type	Date	Item
K2209420	Certificate of Analysis	Jul 26, 2022	F288498
K2209445	Certificate of Analysis	Jul 26, 2022	F288498
L2417237	Certificate of Analysis	Jul 26, 2022	F288498
K2209427	Certificate of Analysis	Jul 26, 2022	F288498
K2209489	Certificate of Analysis	Jul 26, 2022	F288498
K2209399	Certificate of Analysis	Jul 26, 2022	F288498
L2420227	Certificate of Analysis	Jul 26, 2022	F288498

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 42.55, Max Conc. mM: 100
Molecular Weight	425.500 g/mol
XLogP3	4.000
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	425.157 Da
Monoisotopic Mass	425.157 Da
Topological Polar Surface Area	52.200 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	683.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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