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EWP 815 - 98%, high purity , CAS No.20231-01-0

COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
E648767
Grouped product items
SKU Size
Availability
 Price Qty
E648767-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$85.90
E648767-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$140.90
E648767-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$280.90
E648767-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$450.90
E648767-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$720.90
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Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
Amino Acid/Protein Metabolism (1836) Dopamine β-hydroxylase (11) Glucose Metabolism (1943) Metabolic Enzyme/Protease (4860) Phosphatase (222)

Basic Description

Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms EWP 815 is a disulfiram analogue, is a potent inhibitor of Ins(1,4) P 2 phosphatase and Ins(1,4,5) P 3 5-phosphatase . EWP 815 also inhibits enzyme dopamine β-hydroxylase activity.
Storage Temp Store at 2-8°C,Protected from light
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

EWP 815 is a disulfiram analogue, is a potent inhibitor of Ins(1,4) P 2 phosphatase and Ins(1,4,5) P 3 5-phosphatase . EWP 815 also inhibits enzyme dopamine β-hydroxylase activity

In Vitro

EWP 815 inhibits thyrotropin-releasing hormone (TRH; 0.03 mM)-stimulated inositol phospholipid breakdown without affecting basal breakdown rates in prelabelled GH 3 cells with IC 50 s of 83 mM (soluble enzymes) and 71 mM (particulate enzymes), respectively. EWP 815 (30 μM; 1 h) exerts higher inhibition on Ins(1,4) P 2 phosphatase rather than Ins(1,4,5) P 3 5-phosphatase with the mean [ 3 H]Ins(1,4) P 2 /mean [ 3 H]Ins P recovery ratio of 2.6. EWP 815 (6, 8 μM; 10 min) inhibits dephosphorylation of [ 3 H]Ins(1,4,5) P 3 5-phosphatase in particulate and soluble fractions with IC 50 s of 6 μM and 8 μM, respectively. EWP 815 (3-300 μM; 30 min) suppresses thyrotropin-releasing hormone (TRH)-stimulated (100 nM) inositol phospholipid production by 30% (100 μM) and 1.8% (300 μM), respectively, without affecting Ins(1,4,5) P 3 binding. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

EWP 815 (50 mg/kg; i.p.; 30 min before killed) inhibits the enzyme dopamine β-hydroxylase activity in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female mice (20 g)Dosage: 50 mg/kg Administration: Intraperitoneal injection; 30 min before killed Result: Intraperitoneal injection; 30 min before killedInhibited β-hydroxylase of 3 H-α-methyldopamine. Reduced the amount of 3 H-α-Me-NA by 12%.

Form:Solid

IC50& Target:Ins(1,4)P2 phosphatase,Ins(1,4,5)P3 5-phosphatase, ,dopamine β-hydroxylase

Associated Targets(Human)

MGLL Tchem Monoglyceride lipase (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ALDH2 Tclin Aldehyde dehydrogenase (509 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FBP1 Tchem Fructose-1,6-bisphosphatase (1199 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
T47D (39041 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MGLL Tchem Monoglyceride lipase (1909 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Faah Anandamide amidohydrolase (3907 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Smiles CN1CCN(CC1)C(=S)SSC(=S)N2CCN(CC2)C
Isomeric SMILES CN1CCN(CC1)C(=S)SSC(=S)N2CCN(CC2)C
PubChem CID 30054
Molecular Weight 350.59

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Solubility DMSO : 50 mg/mL (142.62 mM; Need ultrasonic)
Molecular Weight 350.600 g/mol
XLogP3 1.300
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 3
Exact Mass 350.073 Da
Monoisotopic Mass 350.073 Da
Topological Polar Surface Area 128.000 Ų
Heavy Atom Count 20
Formal Charge 0
Complexity 315.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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