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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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E111235-100ml
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100ml |
3
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$80.90
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E111235-500ml
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500ml |
2
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$300.90
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| Synonyms | Cyneol | Eucalyptol, 99% | Eucalyptol,(S) | HMS501A15 | NSC6171 | NSC-6171 | Spectrum5_000704 | CCRIS 3727 | EUCALYPTOL (USP MONOGRAPH) | BIDD:ER0481 | Cajeputol | KBio3_001625 | EUCALYPTOL (II) | Germ Free ARIA | 1,8-Epoxy-p-menthane | DTXCID60616 | KBio |
|---|---|
| Specifications & Purity | Moligand™, ≥99.5%(GC), for Determination of o-Cresol |
| Shipped In | Normal |
| Grade | Moligand™ |
| Action Type | ACTIVATOR |
| Mechanism of action | Activator of TRPM8 |
| Product Description |
Eucalyptol is an ingredient in many brands of mouthwash and cough suppressant. It controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition. Eucalyptol is an effective treatment for nonpurulent rhinosinusitis. Eucalyptol reduces inflammation and pain when applied topically. It kills leukaemia cells in vitro. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Oxanes |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Oxanes |
| Alternative Parents | Oxacyclic compounds Dialkyl ethers Hydrocarbon derivatives |
| Molecular Framework | Aliphatic heteropolycyclic compounds |
| Substituents | Oxane - Oxacycle - Ether - Dialkyl ether - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Aliphatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as oxanes. These are compounds containing an oxane (tetrahydropyran) ring, which is a six-member saturated aliphatic heterocycle with one oxygen atom and five carbon atoms. |
| External Descriptors | a monoterpenoid |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Pubchem Sid | 504750601 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504750601 |
| IUPAC Name | 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane |
| INCHI | InChI=1S/C10H18O/c1-9(2)8-4-6-10(3,11-9)7-5-8/h8H,4-7H2,1-3H3 |
| InChIKey | WEEGYLXZBRQIMU-UHFFFAOYSA-N |
| Smiles | CC1(C2CCC(O1)(CC2)C)C |
| Isomeric SMILES | CC1(C2CCC(O1)(CC2)C)C |
| WGK Germany | 2 |
| UN Number | 1993 |
| Packing Group | I |
| Molecular Weight | 154.25 |
| Beilstein | 105109 |
| Reaxy-Rn | 105109 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=105109&ln= |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | May 12, 2025 | E111235 | |
| Certificate of Analysis | Apr 09, 2025 | E111235 | |
| Certificate of Analysis | Jul 26, 2023 | E111235 | |
| Certificate of Analysis | Jul 26, 2023 | E111235 | |
| Certificate of Analysis | May 22, 2022 | E111235 | |
| Certificate of Analysis | May 22, 2022 | E111235 |
| Solubility | Soluble in water(3500 mg/L (at 21°C). Miscible with ether, alcohol, chloroform, glacial acetic acid, oils. Soluble in ethanol, ethyl ether; slightly soluble in carbon tetrachloride. |
|---|---|
| Refractive Index | n20/D 1.457 (lit.) |
| Flash Point(°C) | 48° C |
| Boil Point(°C) | 176-177 °C (lit.) |
| Melt Point(°C) | 1-2 °C (lit.) |
| Molecular Weight | 154.250 g/mol |
| XLogP3 | 2.500 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 154.136 Da |
| Monoisotopic Mass | 154.136 Da |
| Topological Polar Surface Area | 9.200 Ų |
| Heavy Atom Count | 11 |
| Formal Charge | 0 |
| Complexity | 164.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
Starting at $28.90
Starting at $65.90
Starting at $104.90
| 1. Shuai-Nan Zhang, Qi Liu, Xu-Zhao Li, Wu-De Yang, Ying Zhou. (2024) Liver protein and metabolite biolabels reveal hepatoprotective effects and active compounds of Eucommiae folium: Exploration of new application of herb based on multi-omics and bioinformatics. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 239 (115870). |
| 2. Tianyu Huang, Meng Lai, Zhenwei Lin, Ruiqi Luo, Xuezheng Xiang, Haozhe Xu, Ning Pan, Zhaojiang Zuo. (2024) Identification of algicidal monoterpenoids from four chemotypes of Cinnamomum camphora and their algicidal mechanisms on Microcystis aeruginosa. ENVIRONMENTAL RESEARCH, 241 (117714). |
| 3. Shanshan Gao, Xinyi Zhang, Can Zhou, Guangyan Zhang, Yonglei Zhang, Ruimin Li, Kunpeng Zhang. (2023) Minus-C odorant binding protein TcasOBP7G contributes to reproduction and defense against phytochemical in the red flour beetle, Tribolium castaneum. JOURNAL OF ASIA-PACIFIC ENTOMOLOGY, 26 (102151). |
| 4. Hengde Li, Hongna Qin, Shan Jiang, Bao Wang, Jianjiang Zeng, Kaiming Chen, Hao Tang, Yanxiong Fang. (2023) Liquid–liquid equilibria of ternary water—ethyl acetate—1,8-cineole system at different temperatures. FLUID PHASE EQUILIBRIA, 575 (113911). |
| 5. Meng Chen, Qilan Hu, Shengquan Wang, Ling Tao, Xiaoxia Hu, Xiangchun Shen. (2023) 1,8-Cineole ameliorates endothelial injury and hypertension induced by L-NAME through regulation of autophagy via PI3K/mTOR signaling pathway. EUROPEAN JOURNAL OF PHARMACOLOGY, 954 (175863). |
| 6. Zehao Wang, Ru Zhao, Hongfei Gao, Yang Yang, Xinyu Yang, Huiyan Gu, Lei Yang, Xiaonan Zhang, Tingting Liu. (2023) Solvent-free microwave extraction of essential oil and hydrosol from fresh leaves of Cinnamomum burmannii (Nees et T. Nees) Blume after screw extrusion treatment and evaluation of pancreatic lipase inhibitory activities in vitro compared to its main components. INDUSTRIAL CROPS AND PRODUCTS, 202 (116983). |
| 7. Zhangnian Liu, Shiquan Gan, Lingyun Fu, Yini Xu, Shengquan Wang, Guangqiong Zhang, Di Pan, Ling Tao, Xiangchun Shen. (2023) 1,8-Cineole ameliorates diabetic retinopathy by inhibiting retinal pigment epithelium ferroptosis via PPAR-γ/TXNIP pathways. BIOMEDICINE & PHARMACOTHERAPY, 164 (114978). |
| 8. Qiao Heng, Zhu Han, Li Hui, Chen Hongjian, Li Shouyin, Chen Cong, Hao Dejun. (2023) Isolation and characterization of gut bacteria associated with the degradation of host-specific terpenoids in Pagiophloeus tsushimanus (Coleoptera: Curculionidae) larvae. JOURNAL OF INSECT SCIENCE, 23 (2): |
| 9. Qinghan Tang, Fei Xu, Xuchao Wei, Jingyue Gu, Pengli Qiao, Xuemin Zhu, Shaoping Yin, Defang Ouyang, Jie Dong, Junhong Yao, Yiwei Wang, Jun Chen. (2023) Investigation of β-caryophyllene as terpene penetration enhancer: Role of stratum corneum retention. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 183 (106401). |
| 10. Xiaomin Zhang, Gaofeng Hu, Chaoyang Xu, Wen Nie, Kezhou Cai, Hongmei Fang, Baocai Xu. (2023) Inhibition of benzo[a]pyrene formation in charcoal-grilled pork sausages by ginger and its key compounds. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 103 (6): (2838-2847). |
| 11. Youyou Yang, Jing Li, Jiangtao Xing, Weihai Xing, Chaohua Tang, Zhenghua Rao, Junmin Zhang. (2022) Untargeted Profiling and Differentiation of Volatiles in Varieties of Meat Using GC Orbitrap MS. Foods, 11 (24): (3997). |
| 12. Yun-Jiao Ma, Tao Zhou, Wei Jiang, Bei-Wei Zhu, Ming Du, Xian-Bing Xu. (2023) Balanced extraction of volatile and semi-volatile compounds by dynamic linked position unity solid-phase microextraction. FOOD CHEMISTRY, 407 (135160). |
| 13. Xing Huang, Linjie Du, Tiantian Liu, Rui Ma, Xing Liu, Haibin Yuan, Shuai Liu. (2022) Insecticidal Activity of a Component, (-)-4-Terpineol, Isolated from the Essential Oil of Artemisia lavandulaefolia DC. against Plutella xylostella (L.). Insects, 13 (12): (1126). |
| 14. Liu Zhenyi, Wang Jing, Yin Meijuan, Liu Mengsheng, Gao Weijuan. (2022) Gas chromatography-mass spectrometry analysis of variations in the essential leaf oil of 6 Eucalyptus Species and allelopathy of mechanism 1,8-cineole. CIENCIA RURAL, 53 (e20210687). |
| 15. Fulin Li, Lihong Deng, Qiwei Xu, Ke Yuan, Hang Song. (2022) Extractive separation of 1,8-cineole and γ-terpinene with lactic acid-based deep eutectic solvents. JOURNAL OF MOLECULAR LIQUIDS, 363 (119828). |
| 16. Zimin Cai, Qin Wang, Jinzhuan Xu, Jia Zhou, Zhaohui Jiang, Di Pan, Yanyan Zhang, Ling Tao, Jianqing Peng, Yi Chen, Xiangchun Shen. (2022) Enhanced protective activity of 1,8-cineole on emphysema using hyaluronic acid-coated liposomes via quantitative pulmonary administration in mice. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 72 (103402). |
| 17. Chunmei Bai, Qianqian Ma, Qi Li, Lijun Yu, Dong Zhen, Mingjie Liu, Chengxi Wei. (2022) Combination of 1,8-cineole and beta-caryophyllene synergistically reverses cardiac hypertrophy in isoprenaline-induced mice and H9c2 cells. BIOORGANIC CHEMISTRY, 124 (105823). |
| 18. Ke Yuan, Fulin Li, Lincai Peng, Xiaomeng Zhao, Hang Song. (2022) Separation of 1,8-Cineole and terpenes by Liquid-liquid extraction with green alkanediols. JOURNAL OF MOLECULAR LIQUIDS, 350 (118516). |
| 19. Xu Chenyi, Ma Yuandan, Tian Zhengfeng, Luo Qingyun, Zheng Tiefeng, Wang Bin, Zuo Zhaojiang. (2022) Monoterpene emissions and their protection effects on adult Cinnamomum camphora against high temperature. TREES-STRUCTURE AND FUNCTION, 36 (2): (711-721). |
| 20. Yazhou Shao, Anqi Ning, Yue An, Zhibo Hou, Feng Zhou, Chuyu He, Ji Zhang, Junyu Liang. (2021) Evaluation of the composition and fumigant toxicity against Plodia interpunctella of essential oils from Ajania potaninii and Ajania fruticulosa. JOURNAL OF ASIA-PACIFIC ENTOMOLOGY, 24 (1235). |
| 21. Zhengfeng Tian, Qingyun Luo, Zhaojiang Zuo. (2021) Seasonal emission of monoterpenes from four chemotypes of Cinnamomum camphora. INDUSTRIAL CROPS AND PRODUCTS, 163 (113327). |
| 22. Yulin Liang, Junbo Zou, Xiaofei Zhang, Yajun Shi, Jia Tai, Yu Wang, Dongyan Guo, Ming Yang. (2020) Preparation and quality evaluation of a volatile oil microemulsion from Flos magnoliae and Centipeda minima. Molecular Medicine Reports, 22 (6): (4531-4540). |
| 23. Hao Dong, Jiapeng He, Kaijun Xiao, Chao Li. (2019) Temperature-sensitive polyurethane (TSPU) film incorporated with carvacrol and cinnamyl aldehyde: antimicrobial activity, sustained release kinetics and potential use as food packaging for Cantonese-style moon cake. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 55 (1): (293-302). |
| 24. Linghu Ke-Gang, Wu Guo-Ping, Fu Ling-Yun, Yang Hong, Li Hai-Zhi, Chen Yan, Yu Hua, Tao Ling, Shen Xiang-Chun. (2019) 1,8-Cineole Ameliorates LPS-Induced Vascular Endothelium Dysfunction in Mice via PPAR-γ Dependent Regulation of NF-κB. Frontiers in Pharmacology, 10 (178). |
| 25. Xue-min Zhu, Yu Li, Fei Xu, Wei Gu, Guo-jun Yan, Jie Dong, Jun Chen. (2019) Skin Electrical Resistance Measurement of Oxygen-Containing Terpenes as Penetration Enhancers: Role of Stratum Corneum Lipids. MOLECULES, 24 (3): (523). |
| 26. Jun-Bo Zhao, Fang Zhang, Yin-Long Guo. (2019) Quantitative Analysis of Metabolites at the Single-Cell Level by Hydrogen Flame Desorption Ionization Mass Spectrometry. ANALYTICAL CHEMISTRY, 91 (4): (2752–2758). |
| 27. Guo-Feng Mao, Xiao-Chang Mo, Hatem Fouad, Ghulam Abbas, Jian-Chu Mo. (2018) Attraction behaviour of Anagrus nilaparvatae to remote lemongrass (Cymbopogon distans) oil and its volatile compounds. NATURAL PRODUCT RESEARCH, |
| 28. Hengde Li, Li Wan, Guoqiang Chu, Wei Tan, Baoyu Liu, Yanlin Qin, Yuqing Feng, Dalei Sun, Yanxiong Fang. (2017) (Liquid + liquid) extraction of phenols from aqueous solutions with cineole. JOURNAL OF CHEMICAL THERMODYNAMICS, 107 (95). |
| 29. Kegang Linghu, Dan Lin, Hong Yang, Yini Xu, Yanyan Zhang, Ling Tao, Yan Chen, Xiangchun Shen. (2016) Ameliorating effects of 1,8-cineole on LPS-induced human umbilical vein endothelial cell injury by suppressing NF-κB signaling in vitro. EUROPEAN JOURNAL OF PHARMACOLOGY, 789 (195). |
| 30. Gaoming Lei, Peizhi Mao, Minqing He, Longhu Wang, Xuesong Liu, Anyun Zhang. (2015) Combination of column adsorption and supercritical fluid extraction for recovery of dissolved essential oil from distillation waste water of Yulania liliiflora. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 91 (6): (1896-1904). |
| 31. Dongwei Wei, Lishuo Wang, Chao Zhang. (2010) Solid−Liquid Equilibria in Binary Mixtures of 1,8-Cineole with p-Cymene, β-Pinene, and Camphene. JOURNAL OF CHEMICAL AND ENGINEERING DATA, 55 (3): (1456–1458). |
| 32. Hong Yang, Yong-xin Chen, Ke-gang Linghu, Peng-yan Ren, Yu-ting Yao, Feng Jiang, Guo-ping Wu, Ting-ting Chen, Ling Tao, Qian-yun Sun, Yue Li, Xiang-chun Shen. (2024) 1,8-Cineole alleviates Nrf2-mediated redox imbalance and mitochondrial dysfunction in diabetes mellitus by targeting Sirt1. PHYTOMEDICINE, (156099). |
| 33. Jian Zhang, Xinlin Li, Wenqing Cui, Dingchun Lu, Yanyan Zhang, Jiajia Liao, Linlin Guo, Chunen Jiao, Ling Tao, Yini Xu, Xiangchun Shen. (2024) 1,8-cineole ameliorates experimental diabetic angiopathy by inhibiting NLRP3 inflammasome-mediated pyroptosis in HUVECs via SIRT2. BIOMEDICINE & PHARMACOTHERAPY, 177 (117085). |
| 34. Shan Zixiang, Zhou Shixing, Arafat Yasir, Shi Kai, Shao Hua. (2024) Allelopathic Influence of Artemisia lancea Essential Oil on Selected Broad and Narrow Weeds. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 36 (e-20240173). |
| 35. Yingjie Luo, Junjie Qiu, Qiwei Xu, Jing Wei, Hang Song, Beibei Guo, Xuesong Liu, Yong Chen, Tengfei Xu. (2025) An unconventional separation method of α-Terpineol from its isomer 1,8-Cineole via in situ-association formation of deep eutectic solvent and machine learning. JOURNAL OF CHROMATOGRAPHY A, (465677). |
| 36. Jialin Tan, Hao Huang, Hengde Li, Xiaolan Cai, Guangping Zhou, Boxi Zeng, Jinrui He, Xiang Wang, Shaoqu Xie. (2024) Biobutanol extraction and dehydration with eucalyptus oil yielding linear and cyclic biofuel blends. AICHE JOURNAL, 70 (9): (e18495). |
| 37. Longzhu Zhou, Yimeng Ren, Yujie Shi, Shijie Fan, Liyuan Zhao, Miaomiao Dong, Jing Li, Youyou Yang, Yanan Yu, Qingyu Zhao, Junmin Zhang, Chaohua Tang. (2024) Comprehensive foodomics analysis reveals key lipids affect aroma generation in beef. FOOD CHEMISTRY, 461 (140954). |
| 38. Xiaoming Zeng, Hao He, Liejiang Yuan, Haizhi Wu, Cong Zhou. (2024) Determination of 24 Trace Aromatic Substances in Rosemary Hydrosol by Dispersed Liquid–Liquid Microextraction–Gas Chromatography. Processes, 12 (3): (498). |
| 39. Shuning Chen, Ao Yuan, Huafeng Wang, Daibin Yang, Li Cui, Fengjiao Hao, Xiaojing Yan, Huizhu Yuan. (2024) Enhancing agrochemical delivery in citrus leaves with geraniol: a promising strategy for controlling huanglongbing (HLB). PEST MANAGEMENT SCIENCE, |
| 40. You Zhou, De Qiang Qin, Min Xing Zhang, Miao Sun, Lu Sheng Wan, Jing Sheng Chen. (2024) Exploring bioactive molecules with fumigation toxicity against the red imported fire ant Solenopsis invicta Buren from commercial essential oils by GC–MS combined with chemometrics. INDUSTRIAL CROPS AND PRODUCTS, 209 (117993). |
| 41. Yuyan Wei, Ling Xie, Bertrand Muhoza, Qian Liu, Shiqing Song. (2024) Generation of Olfactory Compounds in Cat Food Attractants: Chicken Liver-Derived Protein Hydrolysates and Their Contribution to Enhancing Palatability. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 72 (28): (15906-15919). |
| 42. Gao Shanshan, Cao Yizhuo, Miao Wenbo, Li Dongyu, Zhou Can, Zhang Kunpeng. (2025) Glutathione S-transferase TcGSTu1 contributes to defense against eucalyptol in Tribolium castaneum. GENETICA, 153 (1): (1-11). |
| 43. Jin Liu, Wei Pan, Suzhen Li, Yuanjun Nie, Xinyuan Bi, Xu Jing, Li Li. (2025) Green solvent-based high-throughput dispersive liquid-liquid microextraction for detecting strobilurin fungicides in environmental water samples. JOURNAL OF CHROMATOGRAPHY A, 1749 (465888). |
| 44. Ping Duan, Xiya Feng, Aijun Li, Huijing Chen, Xiaowei Peng, Hongwei Wang, Jianquan Kan. (2024) Identification and characterization of aroma profiles of huajiao oil from different geographical origins using instruments and sensory analysis. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 129 (106074). |
| 45. Meiqian Wang, Ping Zhan, Jingzhang Geng, Peng Wang, Wanying He, Honglei Tian. (2024) Identification and inhibition of key off-odorants in boiled greenfin horse-faced filefish (Thamnaconus septentrionalis) subjected to perilla polyphenols extract. LWT-FOOD SCIENCE AND TECHNOLOGY, 199 (116120). |
| 46. Huanyan Liang, Feifei Lv, Mengting Xian, Chenghua Luo, Lei Zhang, Meihua Yang, Qian Li, Xiangsheng Zhao. (2025) Inhibition Mechanism of Cinnamomum burmannii Leaf Essential Oil Against Aspergillus flavus and Aflatoxins. Foods, 14 (4): (682). |
| 47. Yuwen Chen, Zhishuang Zhu, Weikai Yang, Yu Zhang, Jiawei Yang, Liulian Huang, Huichao Hu, Jianguo Li, Lihui Chen. (2024) Investigating the emission of volatile organic compound from Cinnamomum camphora. INDUSTRIAL CROPS AND PRODUCTS, 219 (119134). |
| 48. Shanshan Gao, Mengyi Guo, Weicheng Yu, Wenbo Miao, Haofei Ya, Dongfeng Liu, Ruimin Li, Kunpeng Zhang. (2024) Odorant binding protein TcOBPC02 contributes to phytochemical defense in the red flour beetle, Tribolium castaneum. ENTOMOLOGICAL RESEARCH, 54 (12): (e70009). |
| 49. Wang Yingying, Zhang Siyi, Ma Yuandan, Du Xianmin, Zong Qi, Lin Die, Lai Meng, Huang Tianyu, Luo Qingyun, Yang Lin, Li Zhanyong, Zuo Zhaojiang. (2024) Solvent effects on terpenoid compositions and antioxidant activities of Cinnamomum camphora (L.) J. Presl extracts and the main antioxidant agent evaluation through in vitro and in vivo assay. Chemical and Biological Technologies in Agriculture, 11 (1): (1-16). |