Basic Description

Synonyms	edtmp \| 1429-50-1 \| Ethylenebis(nitrilodimethylene)tetraphosphonic acid \| Lexidronam \| Ethylenediaminetetra(methylenephosphonic acid) \| [2-[bis(phosphonomethyl)amino]ethyl-(phosphonomethyl)amino]methylphosphonic acid \| EDTMPA \| ((Ethane-1,2-diylbis(azanetriyl))tetrakis
Specifications & Purity	≥95%
Shipped In	Normal

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Organic phosphonic acids and derivatives
    - Subclass Organic phosphonic acids

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Organic phosphonic acids and derivatives
Subclass	Organic phosphonic acids
Intermediate Tree Nodes	Not available
Direct Parent	Organic phosphonic acids
Alternative Parents	Organopnictogen compounds Organophosphorus compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aliphatic acyclic compounds
Substituents	Organophosphonic acid - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organophosphorus compound - Organonitrogen compound - Aliphatic acyclic compound
Description	This compound belongs to the class of organic compounds known as organic phosphonic acids. These are organic compounds containing phosphonic acid.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504752625
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504752625
IUPAC Name	[2-[bis(phosphonomethyl)amino]ethyl-(phosphonomethyl)amino]methylphosphonic acid
INCHI	InChI=1S/C6H20N2O12P4/c9-21(10,11)3-7(4-22(12,13)14)1-2-8(5-23(15,16)17)6-24(18,19)20/h1-6H2,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)
InChIKey	NFDRPXJGHKJRLJ-UHFFFAOYSA-N
Smiles	C(CN(CP(=O)(O)O)CP(=O)(O)O)N(CP(=O)(O)O)CP(=O)(O)O
Isomeric SMILES	C(CN(CP(=O)(O)O)CP(=O)(O)O)N(CP(=O)(O)O)CP(=O)(O)O
WGK Germany	1
Molecular Weight	436.12
Reaxy-Rn	1810320
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1810320&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot Number	Certificate Type	Date	Item
F2526101	Certificate of Analysis	Jul 01, 2025	E409435
C2328501	Certificate of Analysis	Apr 18, 2025	E409435
C2420041	Certificate of Analysis	Apr 01, 2023	E409435
C2328494	Certificate of Analysis	Apr 01, 2023	E409435
F2210276	Certificate of Analysis	Jun 13, 2022	E409435
F2210249	Certificate of Analysis	Jun 13, 2022	E409435
F2210279	Certificate of Analysis	Jun 13, 2022	E409435
F2210277	Certificate of Analysis	Jun 13, 2022	E409435
G2313168	Certificate of Analysis	Jun 13, 2022	E409435

Chemical and Physical Properties

Solubility	Soluble in water
Melt Point(°C)	215-217°C
Molecular Weight	436.120 g/mol
XLogP3	-11.200
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	11
Exact Mass	435.997 Da
Monoisotopic Mass	435.997 Da
Topological Polar Surface Area	237.000 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	486.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Lili Hao, Haoyang Ding, Xiangchuan Xu, Hongli Mao, Zhongwei Gu. (2024) Chelating ligand-bridged IO-Gd nanoparticles with enhanced contrast performance for dual-mode MRI. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY, 184 (54).
2. Wen Li, Wen Liu, Wendi Jia, Jin Zhang, Qi Zhang, Zhenguo Zhang, Jialin Zhang, Yunqi Li, Yiyang Liu, Haining Wang, Yan Xiang,, Shanfu Lu. (2024) Dual-Proton Conductor for Fuel Cells with Flexible Operational Temperature. ADVANCED MATERIALS, (2310584).
3. Chenhao Ni, Ningyi Chen, Jiahui He, Meilan Pan, Xianhua Wang, Bingjun Pan. (2023) Complexation-based selectivity of organic phosphonates adsorption from high-salinity water by neodymium-doped nanocomposite. WATER RESEARCH, 246 (120705).
4. Yongchao Miao, Shuming Wen, Zhenhao Guan, Qicheng Feng. (2023) Utilization of EDTMPA as an eco-friendly depressant for selective flotation separation of cassiterite from calcite in the oleate system. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 674 (131933).
5. Yufei Wang, Na Wei, Jia Zeng, Yaochen Wu, Tong Zhou, Guohan Liu, Qiushan Liu, Jin Guo. (2023) Nitrogen-doped carbon nanotube modified ultrafiltration membrane activating peroxymonosulfate for catalytic transformation of phosphonate and mitigation of membrane fouling. SEPARATION AND PURIFICATION TECHNOLOGY, 314 (123522).
6. Wen-Yuan Fan, Xin Zhang, Pu-Can Guo, Guo-Ping Sheng. (2023) Highly efficient removal of phosphonates by ferrate-induced oxidation coupled with in situ coagulation. JOURNAL OF HAZARDOUS MATERIALS, 451 (131104).
7. Shunlong Pan, Xinrui Guo, Xing Lu, Rong Li, Hao Hu, Xi Nie, Biming Liu, Rong Chen, Mingxin Zhu, Shengqiang Hei, Xianzheng Zhu, Shuo Zhang, Hua Zhou. (2023) Boosting peroxymonosulfate activation by a novel bifunctional core-shell nanoreactor MnFe2O4@HZO for nitrilotris-methylenephosphonic acid removal. APPLIED CATALYSIS B-ENVIRONMENTAL, 330 (122508).
8. Xukun Zhang, Fancheng Meng, Linquan Sun, Zhaowu Zhu, Desheng Chen, Lina Wang. (2022) Influence of Several Phosphate-Containing Additives on the Stability and Electrochemical Behavior of Positive Electrolytes for Vanadium Redox Flow Battery. Energies, 15 (21): (7829).
9. Xiao-Lu Pu, Song Gu, Yan-Fang Xiao, Yu-Zhong Wang, Li Chen. (2022) Novel organophosphonate-decorated WS2 nanosheets towards flame retardancy and mechanical enhancement of epoxy resin. POLYMER DEGRADATION AND STABILITY, 206 (110170).
10. Xiaoqing Qiu, Xule Wan, Zichun Wang, Zhiwei Li, Juan Li, Xiaohong Li, Zhijun Zhang. (2022) A simple and universal strategy for construction and application of silica-based flame-retardant nanostructure. COMPOSITES PART B-ENGINEERING, 238 (109887).
11. Wenduo Wang, Zhengzhou Wang. (2022) Functionalizing mesoporous silica with a nano metal–organic phosphonate towards mechanical-robust, thermal-resistant, and fire-safety epoxy resin. POLYMERS FOR ADVANCED TECHNOLOGIES, 33 (5): (1496-1511).
12. Qiang Chen, Zhengzhou Wang. (2022) A copper organic phosphonate functionalizing boron nitride nanosheet for PVA film with excellent flame retardancy and improved thermal conductive property. COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING, 153 (106738).
13. Lili Hao, Peng Wang, Zhenxu Wu, Zongliang Wang, Yu Wang, Yongzhan Zhu, Zhiqiang Xu, Min Guo, Jiansong Ji, Peibiao Zhang. (2021) EDTMP ligand-enhanced water interactions endowing iron oxide nanoparticles with dual-modal MRI contrast ability. Journal of Materials Chemistry B, 9 (43): (9055-9066).
14. Lei Chen, Huan Wang, Xiaohong Cao, Yue Feng, Zhibing Zhang, Youqun Wang, Yunhai Liu. (2021) Effects of different phosphorus sources on the adsorption of U(Ⅵ) by Zr(Ⅳ) organophosphate hybrids. JOURNAL OF SOLID STATE CHEMISTRY, 302 (122434).
15. Bi Lin, Jun Liu, Yanxing Wang, Fan Yang, Liyu Huang, Ruichan Lv. (2020) Enhanced Upconversion Luminescence-Guided Synergistic Antitumor Therapy Based on Photodynamic Therapy and Immune Checkpoint Blockade. CHEMISTRY OF MATERIALS, 32 (11): (4627–4640).
16. Chun Ding, Xuan Zhang, Shu Xiong, Liang Shen, Ming Yi, Boyang Liu, Yan Wang. (2020) Organophosphonate draw solution for produced water treatment with effectively mitigated membrane fouling via forward osmosis. JOURNAL OF MEMBRANE SCIENCE, 593 (117429).
17. Shu Wang, Shuhui Sun, Chao Shan, Bingcai Pan. (2019) Analysis of trace phosphonates in authentic water samples by pre-methylation and LC-Orbitrap MS/MS. WATER RESEARCH, 161 (78).
18. Yongquan Luo, Lei Zhang, Lingyi Zhang, Bohao Yu, Yajie Wang, Weibing Zhang. (2019) Multiporous Terbium Phosphonate Coordination Polymer Microspheres as Fluorescent Probes for Trace Anthrax Biomarker Detection. ACS Applied Materials & Interfaces, 11 (17): (15998–16005).
19. Shuhui Sun, Shu Wang, Yuxuan Ye, Bingcai Pan. (2019) Highly efficient removal of phosphonates from water by a combined Fe(III)/UV/co-precipitation process. WATER RESEARCH, 153 (21).
20. Liang Shen, Fangqian Wang, Lian Tian, Xuan Zhang, Chun Ding, Yan Wang. (2018) High-performance thin-film composite membranes with surface functionalization by organic phosphonic acids. JOURNAL OF MEMBRANE SCIENCE, 563 (284).
21. Yuhua Dong, Yutong Xie, Jiaqi Yu, Wenjiao Zhang, Xueyan Du, Qiong Zhou. (2025) A novel anti-scaling and protection coating based on hollow periodic mesoporous organosilica encapsulated with scale inhibitor. PROGRESS IN ORGANIC COATINGS, 199 (108942).
22. Hui-Song Hu, Tian-Yu Zhao, Hao Li, Hai-Jing Sun, Lian-Kui Wu, Fa-He Cao. (2025) A novel organic-reinforced zirconium-based composite conversion coating with long-term corrosion resistance property for ADC12 aluminum alloy. Surfaces and Interfaces, 62 (106301).
23. Changxin Dong, Xinhuan Niu, Chao He, Xinjie Li, Zheng Wu, Jiahui Li, Bin Hu, Yunhui Shi, Jiabao Cheng, Xiaodong Luan. (2025) Effects of organic compounds rich in phosphate functional groups as multifunctional inhibitors on copper film chemical-mechanical polishing properties: Combined experiment and theoretical calculation. TRIBOLOGY INTERNATIONAL, 201 (110276).
24. Tingting Xiang, Qingchao Zhu, Tanyu Zhou, Chenglong Chen, Ruibo Wang, Tieyu Hu, Bing Li, Ziwei Xu, Juan Yang. (2024) Tailoring ORR Activity in Fe−N−C Catalysts through Phosphorus Incorporation. CHEMISTRY-A EUROPEAN JOURNAL, (e202403162).

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SKU	Size	Availability	Price
E409435-5g	5g	Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks.	$9.90
E409435-25g	25g	4	$19.90
E409435-100g	100g	≥10	$52.90
E409435-500g	500g	2	$165.90

Ethylenebis(nitrilodimethylene)tetraphosphonic acid - 95%, high purity , CAS No.1429-50-1