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Ethyl 4-hydroxybenzoate - reagent grade,99.0%, high purity , CAS No.120-47-8

    Grade & Purity:
  • CP
  • ≥99%
In stock
Item Number
E105141
Grouped product items
SKU Size
Availability
Price Qty
E105141-100g
100g
9
$11.90
E105141-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$45.90

Basic Description

Synonyms ETHYL HYDROXYBENZOATE [WHO-DD] | 4-Hydroxybenzoic acid ethyl ester | 4-Hydroxy-benzoic acid ethyl ester | bmse010255 | Ethyl 4-Hydroxybenzoate,(S) | ETHYL HYDROXYBENZOATE [WHO-IP] | BBL012166 | MFCD00002353 | Nipazin A | Bonomold OE | Ethyl parahydroxyben
Specifications & Purity CP, ≥99%
Shipped In Normal
Grade CP
Product Description

Ethyl Paraben is an anti-microbial agent used in cosmetic products.
An anti-microbial agent.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Benzoic acids and derivatives
Intermediate Tree Nodes Benzoic acid esters - p-Hydroxybenzoic acid esters
Direct Parent p-Hydroxybenzoic acid alkyl esters
Alternative Parents Benzoyl derivatives  1-hydroxy-2-unsubstituted benzenoids  Carboxylic acid esters  Monocarboxylic acids and derivatives  Organooxygen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic homomonocyclic compounds
Substituents P-hydroxybenzoic acid alkyl ester - Benzoyl - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Carboxylic acid ester - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as p-hydroxybenzoic acid alkyl esters. These are aromatic compounds containing a benzoic acid, which is esterified with an alkyl group and para-substituted with a hydroxyl group.
External Descriptors benzoate ester

Associated Targets(Human)

F2 Tclin Thrombin (11687 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC18A2 Tclin Synaptic vesicular amine transporter (118 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ESR2 Tclin Estrogen receptor beta (9272 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA1 Tclin Carbonic anhydrase I (13240 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA14 Tclin Carbonic anhydrase XIV (1305 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA12 Tclin Carbonic anhydrase XII (6231 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA9 Tclin Carbonic anhydrase IX (8255 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHN (49357 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAKI-1 (44928 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CCRF-CEM (65223 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
COLO 205 (50209 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DLD-1 (17511 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DMS-273 (14108 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HL-60 (67320 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-29 (80576 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
K562 (73714 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KM12 (47707 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
M14 (47487 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MOLT-4 (49676 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-4 (44535 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-5 (45555 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RPMI-8226 (44974 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RXF 393 (41971 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Ca7 Carbonic anhydrase VII (3 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ralstonia solanacearum (520 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488180791
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488180791
IUPAC Name ethyl 4-hydroxybenzoate
INCHI InChI=1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3
InChIKey NUVBSKCKDOMJSU-UHFFFAOYSA-N
Smiles CCOC(=O)C1=CC=C(C=C1)O
Isomeric SMILES CCOC(=O)C1=CC=C(C=C1)O
WGK Germany 1
RTECS DH2190000
Molecular Weight 166.17
Beilstein 1101972
Reaxy-Rn 1101972
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1101972&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number Certificate Type Date Item
D2530163 Certificate of Analysis May 16, 2025 E105141
F2124159 Certificate of Analysis Apr 03, 2025 E105141
A2415187 Certificate of Analysis Jan 18, 2024 E105141
K2214091 Certificate of Analysis Nov 16, 2022 E105141
D2310292 Certificate of Analysis Sep 15, 2022 E105141
I2208759 Certificate of Analysis Sep 15, 2022 E105141
I2208758 Certificate of Analysis Sep 15, 2022 E105141

Chemical and Physical Properties

Solubility Insoluble in water; Degree of Solubility in water: 885 mg/l 25 °C; Very soluble in Alcohol,Ether; Slightly soluble in Chloroform
Sensitivity Light sensitive.
Boil Point(°C) 178°C
Melt Point(°C) 115-118°C
Molecular Weight 166.170 g/mol
XLogP3 2.500
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 3
Exact Mass 166.063 Da
Monoisotopic Mass 166.063 Da
Topological Polar Surface Area 46.500 Ų
Heavy Atom Count 12
Formal Charge 0
Complexity 148.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

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3. Yi Chen, Yongfang Wang, Shasha Song, Xiaoli Zhang, Lili Wu, Jianbing Wu, Xinyu Li.  (2023)  Topical Application of Baicalin Combined with Echinacoside Ameliorates Psoriatic Skin Lesions by Suppressing the Inflammation-Related TNF Signaling Pathway and the Angiogenesis-Related VEGF Signaling Pathway.  ACS Omega,  (43): (40260–40276). 
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5. Jia Shen, Yating Zhu, Fengmei Zhou, Luyu Wang, Manli Guo, Yujuan Cao.  (2023)  Phosphorus-Doped Porous Carbon Coated Graphite Felt as An Efficient and Reusable Cathode for Electro-Fenton Degradation of Parabens.  ChemElectroChem,  10  (18): (e202300255). 
6. Jiangping Cao, Yifei He, Xiaoshuo Zhang, Lei Shi, Baizhao Zeng, Faqiong Zhao.  (2023)  Development of a tributyl phosphate-based hydrophobic deep eutectic solvent for liquid-liquid microextraction of total parabens in beverages.  JOURNAL OF MOLECULAR LIQUIDS,  387  (122593). 
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13. Lizhen Qiao, Yuan Tao, Honglin Qin, Ruiting Niu.  (2023)  Multi-magnetic center ionic liquids for dispersive liquid-liquid microextraction coupled with in-situ decomposition based back-extraction for the enrichment of parabens in beverage samples.  JOURNAL OF CHROMATOGRAPHY A,  1689  (463771). 
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16. Jiangping Cao, Lei Shi, Yifei He, Yuwen Liu, Faqiong Zhao.  (2022)  Effective extraction of parabens from toothpaste by vortex-assisted liquid-phase microextraction based on low viscosity deep eutectic solvent.  MICROCHEMICAL JOURNAL,  179  (107590). 
17. Yi-qiu Liu, Dandan Zhang, Junyu Deng, Ye Liu, Wei Li, Xuqiang Nie.  (2022)  Preparation and Safety Evaluation of Centella asiatica Total Glycosides Nitric Oxide Gel and Its Therapeutic Effect on Diabetic Cutaneous Ulcers.  Evidence-based Complementary and Alternative Medicine,  2022  (1419146). 
18. Nan Zhao, Xiuxiu Wang, Liru Yao, Huixuan Yan, Ban Qin, Chensha Li, Jianqi Zhang.  (2022)  Actuation performance of a liquid crystalline elastomer composite reinforced by eiderdown fibers.  Soft Matter,  18  (6): (1264-1274). 
19. Ning Xiao, Feng Xiao, Jinzhang Gao, Zhengkun Xu, Qianlei Wang, Jiajie Kuai, Wei Wei, Chun Wang.  (2021)  Effects of paeoniflorin-6′-O-benzene sulfonate on the pharmacokinetics, excretion and tissue distribution of leflunomide in rats.  BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,  130  (3): (364-374). 
20. Zhimin Gong, Gaobo Wang, Shuai Shao, Mengjie Wang, Kun Lu, Shixiang Gao.  (2022)  Co-degradation of coexisting pollutants methylparaben (mediators) and amlodipine in enzyme-mediator systems: Insight into the mediating mechanism.  JOURNAL OF HAZARDOUS MATERIALS,  423  (127112). 
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23. Xun Gao, Kai Xu, Miaomiao Chi, Jiaojiao Li, Lingzhe Suo, Lin Zhu, Kexin Chen, Jingqing Mu.  (2021)  Determination of four parabens in cosmetics by high-performance liquid chromatography with magnetic solid-phase and ionic dispersive liquid–liquid extraction.  REVIEWS IN ANALYTICAL CHEMISTRY,  40  (1): (161-172). 
24. Yuanyuan Fu, Zhentao Li, Qiaoyan Li, Changjun Hu, Yikun Liu, Wenqi Sun, Zilin Chen.  (2021)  In situ room-temperature preparation of a covalent organic framework as stationary phase for high-efficiency capillary electrochromatographic separation.  JOURNAL OF CHROMATOGRAPHY A,  1649  (462239). 
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30. Ping Zhong, Xuehong Chen, Rishuo Guo, Xiaomei Chen, Zhihao Chen, Cui Wei, Yusheng Li, Wanting Wang, Yi Zhou, Linghao Qin.  (2020)  Folic Acid-Modified Nanoerythrocyte for Codelivery of Paclitaxel and Tariquidar to Overcome Breast Cancer Multidrug Resistance.  MOLECULAR PHARMACEUTICS,  17  (4): (1114–1126). 
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35. Tiemei Li, Yuefei Song, Jingjie Xu, Jing Fan.  (2019)  A hydrophobic deep eutectic solvent mediated sol-gel coating of solid phase microextraction fiber for determination of toluene, ethylbenzene and o-xylene in water coupled with GC-FID.  TALANTA,  195  (298). 
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51. Kaikai Xu, Lulu Kong, Kebin Ye, Beibei Xu, Yongming Deng, Yicheng Wang, Shaohua Wei.  (2025)  NiPc-Cu 2D MOF: Facile and scalable synthesis of an antimicrobial agent rivaling clinical antibiotics.  INORGANIC CHEMISTRY COMMUNICATIONS,  177  (114343). 
52. Yi Chen, Shasha Song, Yongfang Wang, Xiaoli Zhang, Jiafen Zhang, Lili Wu, Jianbing Wu, Xinyu Li.  (2024)  Topical application of berberine ameliorates imiquimod-induced psoriasis-like dermatitis in BALB/c mice via suppressing JAK1/STAT1 signaling pathway.  Arabian Journal of Chemistry,  17  (105612). 
53. Yi Chen, Shasha Song, Yongfang Wang, Lili Wu, Jianbing Wu, Zhengmeng Jiang, Xinyu Li.  (2024)  Topical application of magnolol ameliorates psoriasis-like dermatitis by inhibiting NLRP3/Caspase-1 pathway and regulating tryptophan metabolism.  BIOORGANIC CHEMISTRY,    (108059). 

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