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Ethinyl Estradiol - 10mM in DMSO, high purity , CAS No.57-63-6(DMSO), Estrogen receptor alpha agonist

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Item Number
E407833
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E407833-1ml
1ml
Available within 8-12 weeks(?)
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$141.90

Estrogen receptor Selective Inhibitors | Activators | Agonists | Antagonists | Chemicals | Modulators

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Compound libraries (12325)

Basic Description

Synonyms (17α)​-19-​Norpregna-​1,​3,​5(10)​-​trien-​20-​yne-​3,​17-​diol
Specifications & Purity Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms Ethinyl Estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.
Storage Temp Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type AGONIST, INHIBITOR
Mechanism of action Estrogen receptor alpha agonist
Product Description

Information

Ethinyl Estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills.
In vitro

Ethinyl Estradiol increases respiratory chain activity in both cultured rat hepatocytesand HepG2 cells. Ethinyl estradiol is a strong promoter of hepatocarcinogenesis. Ethinyl Estradiol enhances the transcript levels of nuclear genome- and mitochondrial genome-encoded genes and respiratory chain activity in female rat liver, and also inhibits transforming growth factor beta (TGFbeta)-induced apoptosis in cultured liver slices and hepatocytes from female rats. Ethinyl Estradiol increases the transcript levels of the mitochondrial genome-encoded genes cytochrome oxidase subunits I, II, and III in cultured female rathepatocytes. Ethinyl Estradiol significantly increases both the levels of glutathione (reduced [GSH] and oxidized [GSSG] forms) per mg protein in mitochondria and nuclei, while the percentage of total glutathione in the oxidized form is not affected.

In vivo

Ethinyl Estradiol (50 mg/kg/day) increases anogenital distance and reduces pup body weight at postnatal day 2, accelerates the age at vaginal opening, reduces F1 fertility and F2 litter sizes, and induces malformations of the external genitalia (5 mg/kg) in the female Long-Evans rat. Ethinyl Estradiol increases the number of low density lipoprotein (LDL) receptors in livers of rats, thereby producing a profound fall in plasma cholesterol levels. Ethinyl Estradiol exerts the same effect in livers of male and female rabbits and that the increase in receptor number is correlated with a 6- to 8-fold increase in the levels of receptor mRNA.
Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥98%

Product Properties

ALogP 4.886
HBD Count 1

Associated Targets(Human)

CYP2B6 Tchem Cytochrome P450 2B6 (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ESR1 Tclin Estrogen receptor (6 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ESR2 Tclin Estrogen receptor beta (5 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SULT1A1 Tchem Sulfotransferase 1A1 (6 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SLC6A2 Tclin Sodium-dependent noradrenaline transporter (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SLC6A3 Tclin Sodium-dependent dopamine transporter (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SLC6A4 Tclin Sodium-dependent serotonin transporter (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SHBG Tchem Sex hormone-binding globulin (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
AOX1 Tchem Aldehyde oxidase (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Names and Identifiers

Smiles CC12CCC3C(CCC4=CC(=CC=C34)O)C1CCC2(O)C#C
Molecular Weight 296.4
Reaxy-Rn 2624727
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2624727&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Solubility Solubility (25°C) In vitro      
DMSO(mg / mL) Max Solubility 59
DMSO(mM) Max Solubility 199.06
Water(mg / mL) Max Solubility <1

Citations of This Product

1. Yanting Li, Shu Zhu, Hua Zhao, Yan Xiong, Tao Gong, Yanru Tao, Jin Li, Jiangling Hu, Hongmei Wang, Xinhui Jiang.  (2024)  Cubic cobalt ferrite anchored on graphene sheets for non-enzymatic electrochemical detection of 17α-ethinyl estradiol in environmental and biological samples.  Journal of Environmental Chemical Engineering,  12  (111612). 
2. Si-xuan Zhou, Xiao-tong Lin, Jie Wang, Hai-xiang Wang, Gui-tang Chen.  (2023)  Novel hydrocortisone magnetic molecularly imprinted polymers: Preparation, characterization, and application.  FOOD CHEMISTRY,  421  (136196). 
3. Lei Miao, Shanshan Sun, Tian Ma, Yousif Abdelrahman Yousif Abdellah, Yue Wang, Yaozu Mi, Haohao Yan, Guanjun Sun, Ning Hou, Xinyue Zhao, Chunyan Li, Hailian Zang.  (2023)  A Novel Estrone Degradation Gene Cluster and Catabolic Mechanism in Microbacterium oxydans ML-6.  APPLIED AND ENVIRONMENTAL MICROBIOLOGY,  89  (3):  
4. Yunning Chen, Renquan Guan, Xueying Cheng, Jie Zhao, Zhengkai Wu, Yan Wang, Qingkun Shang, Yingnan Sun.  (2023)  Construction of surface oxygen vacancies by bimetallic doping combined with ellagic acid modification to enhance the photocatalytic degradation of ethinyl estradiol by TiO2.  CHEMICAL ENGINEERING JOURNAL,  455  (140929). 
5. Yan Wu, Panpan Cao, Yanhao Jiang, Yanjuan Liu, Yuefei Zhang, Wei Chen, Zhengwu Bai, Sheng Tang.  (2022)  Ingenious introduction of aminopropylimidazole to tune the hydrophobic selectivity of dodecyl-bonded stationary phase for environmental organic pollutants.  MICROCHEMICAL JOURNAL,  182  (107933). 
6. Yong Zhang, Kaifang Wei, Litao Wang, Guihua Gao.  (2022)  A membrane solid-phase extraction method based on MIL-53-mixed-matrix membrane for the determination of estrogens and parabens: Polyvinylidene difluoride membrane versus polystyrene-block-polybutadiene membrane.  BIOMEDICAL CHROMATOGRAPHY,  36  (11): (e5454). 
7. Shuo Qi, Xiaoze Dong, Yuhan Sun, Yin Zhang, Nuo Duan, Zhouping Wang.  (2022)  Split aptamer remodeling-initiated target-self-service 3D-DNA walker for ultrasensitive detection of 17β-estradiol.  JOURNAL OF HAZARDOUS MATERIALS,  439  (129590). 
8. Yan Du, Xiaohui Yan, Yuanbo Chen, Yi Wu, Qiankun Qiu, Yanshuo Li, Dapeng Wu.  (2022)  Magnetic polyimide nanosheet microspheres for trace analysis of estrogens in aqueous samples by magnetic solid-phase extraction-gas chromatography–mass spectrometry.  JOURNAL OF CHROMATOGRAPHY A,  1675  (463184). 
9. Yuping Zhang, Ning Wang, Zhenyu Lu, Na Chen, Chengxing Cui, Xinxin Chen.  (2022)  Smart Titanium Wire Used for the Evaluation of Hydrophobic/Hydrophilic Interaction by In-Tube Solid Phase Microextraction.  MOLECULES,  27  (7): (2353). 
10. Qianyu Li, Guoliang Li, Lihua Fan, Yanxin Yu, Jin Liu.  (2022)  Click reaction triggered turn-on fluorescence strategy for highly sensitive and selective determination of steroid hormones in food samples.  FOOD CHEMISTRY,  374  (131565). 
11. Xiaoxiao Zhu, Yijun Zhang, Pengfei Liu, Xiuzhi Bai, Na Chen, Yuping Zhang.  (2021)  Carbonized Aramid Fiber as the Adsorbent for In-Tube Solid-Phase Microextraction to Detect Estrogens in Water Samples.  Journal of Chemistry,  2021  (9970518). 
12. Shenling Wang, Yanling Geng, Xiaowei Sun, Rongyu Wang, Zhenjia Zheng, Shenghuai Hou, Xiao Wang, Wenhua Ji.  (2020)  Molecularly imprinted polymers prepared from a single cross-linking functional monomer for solid-phase microextraction of estrogens from milk.  JOURNAL OF CHROMATOGRAPHY A,  1627  (461400). 
13. Jian Wang, Xian Zhou, Michael Gatheru Waigi, Fredrick Owino Gudda, Pengfei Cheng, Wanting Ling.  (2019)  Simultaneous Removal of Estrogens and Antibiotics from Livestock Manure Using Fenton Oxidation Technique.  Catalysts,  (8): (644). 
14. Siyao Liu, Yuqing Chen, Ying Wang, Guohua Zhao.  (2019)  Group-Targeting Detection of Total Steroid Estrogen Using Surface-Enhanced Raman Spectroscopy.  ANALYTICAL CHEMISTRY,  91  (12): (7639–7647). 
15. Yan Xing, Jing Cheng, Mengfei Zhang, Meng Zhao, Liyan Ye, Wei Pan.  (2018)  A Novel Inorganic Ni–La2O3 Composite with Superfast and Versatile Water Purification Behavior.  ACS Applied Materials & Interfaces,  10  (50): (43723–43729). 
16. Xiaoli Qi, Hui Hu, Yuesuo Yang, Yunxian Piao.  (2018)  Graphite nanoparticle as nanoquencher for 17β-estradiol detection using shortened aptamer sequence.  ANALYST,  143  (17): (4163-4170). 
17. Lei Chen, Mingyue Zhang, Fengfu Fu, Jingguang Li, Zian Lin.  (2018)  Facile synthesis of magnetic covalent organic framework nanobeads and application to magnetic solid-phase extraction of trace estrogens from human urine.  JOURNAL OF CHROMATOGRAPHY A,  1567  (136). 
18. Xiaojiao Du, Ding Jiang, Liming Dai, Weiran Zhu, Xiaodi Yang, Nan Hao, Kun Wang.  (2018)  Oxygen Vacancy Engineering in Europia Clusters/Graphite-Like Carbon Nitride Nanostructures Induced Signal Amplification for Highly Efficient Electrochemiluminesce Aptasensing.  ANALYTICAL CHEMISTRY,  90  (5): (3615–3620). 
19. Guihua Gao, Sijia Li, Shuo Li, Yudan Wang, Pan Zhao, Xiangyu Zhang, Xiaohong Hou.  (2018)  A combination of computational−experimental study on metal-organic frameworks MIL-53(Al) as sorbent for simultaneous determination of estrogens and glucocorticoids in water and urine samples by dispersive micro-solid-phase extraction coupled to UPLC-MS/MS.  TALANTA,  180  (358). 
20. Xiaoyun Lei, Yang Li, Lu Yu, Siying Meng, Haitao Xu, Rui Wu, Junhai Liu, Xinxin Zhao, Zuoping Zhao.  (2025)  A reliable fluorescent aptasensor for selective detection of trace estradiol based on metal–organic framework click-grafting aptamers functionalized fabric.  MICROCHEMICAL JOURNAL,  210  (113010). 
21. Xu Jiaqi, Li Qianyu, Li Wenrui, Wu Di, Wu Yongning, Li Guoliang.  (2025)  Efficient adsorption and detection of steroid hormones in foods through the combination of novel magnetic TAPB-COF materials with click isotope probes.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,    (1-14). 
22. Wei Yuan, Yipeng Wang, Meng Jiang, Yan Jin, Wen Yan, Qingyu Wang, Lingmei Niu.  (2025)  Research on a molecularly imprinted electrochemical sensor based on a graphene quantum dot-gold nanoparticle composite for the determination of 17β-estradiol.  Analytical Methods,     

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