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Esculin hydrate - 98%, high purity , CAS No.531-75-9

3 Citations COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
E107333
Grouped product items
SKU Size
Availability
 Price Qty
E107333-1g
1g
5
$20.90
E107333-5g
5g
4
$80.90
E107333-25g
25g
3
$363.90
E107333-100g
100g
1
$1,308.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Antioxidant. Plant coumarin glucoside.

View related series
MAPK/ERK Pathway (546) p38 MAPK (136)

Basic Description

Synonyms 2H-1-Benzopyran-2-one, 6-(beta-D-glucopyranosyloxy)-7-hydroxy- | AKOS015895151 | SR-01000633930-1 | Z1494829512 | aesculin | CAS-531-75-9 | 7-hydroxy-2-oxo-2H-chromen-6-yl beta-D-glucopyranoside | C09264 | DTXCID5025318 | 7-hydroxy-6-(((2S,3R,4S,5S,6R)-3,
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Antioxidant and plant coumarin glucoside. Exerts SOD-mimetic effects and reduces superoxide radicals generation. Inhibitory effects of chemically induced oxidative DNA damage and carcinogenesis in vivo.
Shipped In Normal
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Product Introduction

Esculin hydrate has vasoprotective and venotonic properties.


Application

Esculin hydrate has been used as a component of sporulation-inducing esculin agar. It has also been used for esculin uptake assay.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Coumarins and derivatives
Subclass Coumarin glycosides
Intermediate Tree Nodes Not available
Direct Parent Coumarin glycosides
Alternative Parents Phenolic glycosides  7-hydroxycoumarins  Hexoses  O-glycosyl compounds  1-benzopyrans  Pyranones and derivatives  1-hydroxy-2-unsubstituted benzenoids  Oxanes  Heteroaromatic compounds  Lactones  Secondary alcohols  Oxacyclic compounds  Acetals  Polyols  Primary alcohols  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Coumarin o-glycoside - Coumarin-6-o-glycoside - Phenolic glycoside - 7-hydroxycoumarin - Hydroxycoumarin - Hexose monosaccharide - O-glycosyl compound - Glycosyl compound - Benzopyran - 1-benzopyran - Pyranone - 1-hydroxy-2-unsubstituted benzenoid - Pyran - Monosaccharide - Oxane - Benzenoid - Heteroaromatic compound - Secondary alcohol - Lactone - Acetal - Oxacycle - Organoheterocyclic compound - Polyol - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Alcohol - Primary alcohol - Organooxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as coumarin glycosides. These are aromatic compounds containing a carbohydrate moiety glycosidically bound to a coumarin moiety.
External Descriptors coumarins

Associated Targets(Human)

MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MIF Tchem Macrophage migration inhibitory factor (979 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLA Tclin Alpha-galactosidase A (5444 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CASP1 Tchem Caspase-1 (6235 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CASP7 Tchem Caspase-7 (3146 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Homo sapiens (32628 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TAS2R16 Tchem Taste receptor type 2 member 16 (102 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
dsDNA (365 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
quadruplex DNA (2700 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

pol Human immunodeficiency virus type 1 reverse transcriptase (18245 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cruzipain (33337 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
pol Human immunodeficiency virus type 1 integrase (9041 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
C6 (2371 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Impa1 Inositol monophosphatase 1 (16203 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488195236
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488195236
IUPAC Name 7-hydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one
INCHI InChI=1S/C15H16O9/c16-5-10-12(19)13(20)14(21)15(24-10)23-9-3-6-1-2-11(18)22-8(6)4-7(9)17/h1-4,10,12-17,19-21H,5H2/t10-,12-,13+,14-,15-/m1/s1
InChIKey XHCADAYNFIFUHF-TVKJYDDYSA-N
Smiles C1=CC(=O)OC2=CC(=C(C=C21)OC3C(C(C(C(O3)CO)O)O)O)O
Isomeric SMILES C1=CC(=O)OC2=CC(=C(C=C21)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O
RTECS DJ3085000
Molecular Weight 340.28(anhydrous)
Beilstein 18(3/4)1326
Reaxy-Rn 1297608
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1297608&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot Number Certificate Type Date Item
C1922108 Certificate of Analysis Jan 12, 2023 E107333
L2213356 Certificate of Analysis Oct 20, 2022 E107333
L2213173 Certificate of Analysis Oct 20, 2022 E107333
L2213161 Certificate of Analysis Oct 20, 2022 E107333
L2213342 Certificate of Analysis Oct 20, 2022 E107333
L2213163 Certificate of Analysis Oct 20, 2022 E107333
L2213132 Certificate of Analysis Oct 20, 2022 E107333
L2213378 Certificate of Analysis Oct 20, 2022 E107333
L2213143 Certificate of Analysis Oct 20, 2022 E107333

Chemical and Physical Properties

Specific Rotation[α] -79 ° (C=2.4, 50% Dioxane)
Melt Point(°C) 203-205°C
Molecular Weight 340.280 g/mol
XLogP3 -0.600
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 3
Exact Mass 340.079 Da
Monoisotopic Mass 340.079 Da
Topological Polar Surface Area 146.000 Ų
Heavy Atom Count 24
Formal Charge 0
Complexity 495.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 5
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Yin Lu, Yuan Zhang, Kan Zhang.  (2022)  Renewable biomass resources to access halogen- and phosphorus-free flame retardant thermosets with ultra-low heat release capacity.  CHEMICAL ENGINEERING JOURNAL,  448  (137670). 
2. Lizhen Chen, Jie Wu, Feng Yan, Huangxian Ju.  (2021)  A facile strategy for quantitative sensing of glycans on cell surface using organic electrochemical transistors.  BIOSENSORS & BIOELECTRONICS,  175  (112878). 
3. Yuanyang Dong, Qihang Hou, Meng Sun, Jingjing Sun, Bingkun Zhang.  (2020)  Targeted Isolation of Antioxidant Constituents from Plantago asiatica L. and In Vitro Activity Assay.  MOLECULES,  25  (8): (1825). 

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