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Eplivanserin hemifumarate - ≥98%(HPLC), high purity , CAS No.130580-02-8

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 130580-02-8
Molecular Weight: 386.42
PubChem CID: 135456189

In stock

Item Number

E288211

Grouped product items
SKU	Size	Availability	Price
E288211-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$42.90
E288211-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$149.90
E288211-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$155.90
E288211-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$529.90
E288211-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$655.90

Potent and selective 5-HT2Aantagonist

View related series

5-hydroxytryptamine receptor (1) Class A GPCR (4138)

Basic Description

Synonyms	BT8UYC46KA \| SR 46349 \| Eplivanserinhemifumarate \| Eplivanserin fumarate [USAN] \| SR46349B \| SR-46349B \| SR 46349B \| UNII-BT8UYC46KA \| Eplivanserin hemifumarate
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent and selective 5-HT2Aantagonist (IC50values are 5.8 and 120 and >100 nM for 5-HT2A, 5-HT2Band 5-HT2C, respectively). Attenuates cocaine-induced hyperactivity. Increases dopamine (DA) release in rat medial prefrontal cortex (mPFC); potentiates halope
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Eplivanserin (SR-46349) hemifumarate is a potent, selective and orally active 5-HT2A receptor antagonist, with an IC50 of 5.8 nM in rat cortical membrane, and a Kd of 1.14 nM. Eplivanserin hemifumarate displays >20-fold selectivity more selective for 5-HT2A than 5-HT2B and 5-HT2C.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class Linear 1,3-diarylpropanoids
    - Subclass Cinnamylphenols

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Linear 1,3-diarylpropanoids
Subclass	Cinnamylphenols
Intermediate Tree Nodes	Not available
Direct Parent	Cinnamylphenols
Alternative Parents	Styrenes Fluorobenzenes 1-hydroxy-2-unsubstituted benzenoids Unsaturated fatty acids Dicarboxylic acids and derivatives Aryl fluorides Trialkylamines Carboxylic acids Organofluorides Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Not available
Substituents	Cinnamylphenol - Styrene - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Fluorobenzene - Halobenzene - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - Dicarboxylic acid or derivatives - Fatty acyl - Fatty acid - Benzenoid - Unsaturated fatty acid - Tertiary aliphatic amine - Tertiary amine - Carboxylic acid derivative - Carboxylic acid - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Amine - Carbonyl group - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Organohalogen compound - Organofluoride - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as cinnamylphenols. These are organic compounds containing the 1,3-diphenylpropene moiety with one benzene ring bearing one or more hydroxyl groups.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	(E)-but-2-enedioic acid;4-[(E,3Z)-3-[2-(dimethylamino)ethoxyimino]-3-(2-fluorophenyl)prop-1-enyl]phenol
INCHI	InChI=1S/2C19H21FN2O2.C4H4O4/c21-22(2)13-14-24-21-19(17-5-3-4-6-18(17)20)12-9-15-7-10-16(23)11-8-15;5-3(6)1-2-4(7)8/h23-12,23H,13-14H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b2*12-9+,21-19-;2-1+
InChIKey	RNLKLYQQDLHHBH-ABDBJYMXSA-N
Smiles	CN(C)CCON=C(C=CC1=CC=C(C=C1)O)C2=CC=CC=C2F.CN(C)CCON=C(C=CC1=CC=C(C=C1)O)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O
Isomeric SMILES	CN(CCO/N=C(\C1=CC=CC=C1F)/C=C/C2=CC=C(C=C2)O)C.CN(CCO/N=C(\C1=CC=CC=C1F)/C=C/C2=CC=C(C=C2)O)C.C(=C/C(=O)O)\C(=O)O
WGK Germany	2
PubChem CID	135456189
Molecular Weight	386.42

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 19.32, Max Conc. mM: 50
Sensitivity	Moisture sensitive
Molecular Weight	772.800 g/mol
XLogP3
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	16
Exact Mass	772.328 Da
Monoisotopic Mass	772.328 Da
Topological Polar Surface Area	165.000 Å²
Heavy Atom Count	56
Formal Charge	0
Complexity	537.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	5
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	5
Covalently-Bonded Unit Count	3

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