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Enpp/Carbonic anhydrase-IN-1 - 99%, high purity , CAS No.2883495-35-8

COA

Grade & Purity:

≥99%

Cas Number: 2883495-35-8
Molecular Weight: 411.51

In stock

Item Number

E649829

Grouped product items
SKU	Size	Availability	Price
E649829-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$80.90
E649829-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$125.90
E649829-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$250.90
E649829-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$400.90
E649829-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$650.90

View related series

Apoptosis (4276) Carbonic Anhydrase (39) Glucose Metabolism (1943) Metabolic Enzyme/Protease (4860) Nucleic Acid Metabolism (395) Phosphodiesterase (PDE) (252)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent Enpp and carbonic anhydrase inhibitor with IC 50 s of 1.36, 1.35, 3.00, 0.88, 1.02 μM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 shows antiproliferative activity for
Storage Temp	Protected from light,Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent Enpp and carbonic anhydrase inhibitor with IC 50 s of 1.36, 1.35, 3.00, 0.88, 1.02 μM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-1 induces Apoptosis In Vitro Enpp/Carbonic anhydrase-IN-1 (compound 1e) (0-100 µM; ) inhibits some cancer cells growth with IC 50 s of 0.32, 0.40, 0.58, 0.87, 0.40, 0.96 µM for K-562, RPMI-8226, SR, COLO 205, HT-29, SF-539 cells, respectively. Enpp/Carbonic anhydrase-IN-1 (0-2 µM) shows low cytotoxic against normal breast epithelial cells (HME1) and normal skin fibroblast cells (F180) with IC 50 s of > 50 μM. Enpp/Carbonic anhydrase-IN-1 (0.32, 0.64 µM) induces apoptosis in a dose-dependent manner at K-562 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: K-562, RPMI-8226, SR, COLO 205, HT-29, SF-539 cells Concentration: 0-100 µM Incubation Time: Result: Inhibited the cell growth with IC 50 s of 0.32, 0.40, 0.58, 0.87, 0.40, 0.96 µM for K-562, RPMI-8226, SR, COLO 205, HT-29, SF-539 cells, respectively. Apoptosis AnalysisCell Line: K-562 cells Concentration: 0.32, 0.64 µM Incubation Time: Result: Induced apoptosis in a dose-dependent manner. Form:Solid IC50& Target:CA Ⅱ 0.88 μM (IC 50 ) CA Ⅸ 1.02 μM (IC 50 ) NPP1 1.36 μM (IC 50 ) NPP2 1.35 μM (IC 50 ) NPP3 3.00 μM (IC 50 )

Names and Identifiers

Smiles	O=S(C1=CC=CC=C1)(OC2=CC=C(C=C2)NC(C34CC5CC(C4)CC(C3)C5)=O)=O
Molecular Weight	411.51

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 100 mg/mL (243.01 mM; ultrasonic and warming and heat to 50°C)

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