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Enpp-1-IN-12 - 99%, high purity , CAS No.2631703-41-6

COA

Grade & Purity:

≥99%

Cas Number: 2631703-41-6
Molecular Weight: 374.42

In stock

Item Number

E648729

Grouped product items
SKU	Size	Availability	Price
E648729-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$340.90
E648729-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$580.90
E648729-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,150.90

View related series

Metabolic Enzyme/Protease (4860) Nucleic Acid Metabolism (395) Phosphodiesterase (PDE) (252)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Enpp-1-IN-12 (compound 43) is a potent and orally active ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor, with a Ki of 41 nM. Enpp-1-IN-12 exhibits anti-tumor activity.
Storage Temp	Store at 2-8°C,Protected from light,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Enpp-1-IN-12 (compound 43) is a potent and orally active ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor, with a Ki of 41 nM. Enpp-1-IN-12 exhibits anti-tumor activity In Vitro Enpp-1-IN-12 (5 μM) exhibits half-life and intrinsic clearance of >120 min and <11.55 μL/min/million cells and 61.88 min and 22.4 μL/min/million cells in human and mouse hepatocytes, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Enpp-1-IN-12 (100 mg/kg; p.o.) inhibits tumor growth in LLC1 syngeneic murine tumor model for lung cancer . Enpp-1-IN-12 (10 mg/kg; p.o.) exhibits moderate oral bioavailability (F=45.1%), half-life (t 1/2 =1.04 h), and C max (303.10 ng/mL) in healthy female BALB/c mice . Enpp-1-IN-12 (1 mg/kg; i.v.) exhibits half-life (t 1/2 =0.76 h), C max (308.64 ng/mL), and CL of 73.22 mL/min/kg in healthy female BALB/c mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 41 nM (ENPP1)

Names and Identifiers

Smiles	O=C(C(CC)SC1=NC(N)=NC2=C1NC=N2)NC3=CC=C(C(OC)=C3)O
Molecular Weight	374.42

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