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Endomorphin 2 TFA - 98%, high purity , CAS No.141801-26-5, Agonist of μ receptor

COA COA
In stock
Item Number
E118809
Grouped product items
SKU Size
Availability
 Price Qty
E118809-5mg
5mg
3
$86.90
E118809-10mg
10mg
5
$156.90
E118809-25mg
25mg
4
$332.90
E118809-50mg
50mg
3
$598.90
E118809-100mg
100mg
3
$1,077.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Potent, selective μ opioid receptor agonist

View related series
Class A GPCR (4138) GPCR/G Protein (3172) Neuronal Signaling (3320) Opioid Receptor (113) μ receptor Agonist (41)

Basic Description

Synonyms l-tyrosyl-l-prolyl-l-phenylalanyl-l-phenylalaninamide, (-)- | TETRAPEPTIDE-15 [INCI] | NCGC00163677-01 | 3PH5M0466G | tyrosyl-prolyl-phenylalanyl-phenylalaninamide | (2S)-2-{[(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidin-2-yl]formamido}-N-[
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms Potent endogenous μ opioid receptor agonist (K i values are 0.69, 9.23 and 5.24 nM for opioid receptor subtypes μ, δ and κ, respectively). Antinociceptive activity. Limited ability to cross the blood-brain barrier.
Storage Temp Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type AGONIST
Mechanism of action Agonist of μ receptor
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Amino acids, peptides, and analogues
Intermediate Tree Nodes Peptides
Direct Parent Oligopeptides
Alternative Parents Phenylalanine and derivatives  N-acyl-alpha amino acids and derivatives  Proline and derivatives  Alpha amino acid amides  Amphetamines and derivatives  N-acylpyrrolidines  Pyrrolidinecarboxamides  1-hydroxy-2-unsubstituted benzenoids  Aralkylamines  Fatty amides  Tertiary carboxylic acid amides  Primary carboxylic acid amides  Secondary carboxylic acid amides  Azacyclic compounds  Organopnictogen compounds  Organic oxides  Monoalkylamines  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Alpha-oligopeptide - Phenylalanine or derivatives - Proline or derivatives - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Amphetamine or derivatives - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - N-acylpyrrolidine - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Aralkylamine - Monocyclic benzene moiety - Fatty amide - Benzenoid - Fatty acyl - Pyrrolidine - Tertiary carboxylic acid amide - Amino acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Primary carboxylic acid amide - Organoheterocyclic compound - Azacycle - Organopnictogen compound - Primary aliphatic amine - Organic oxygen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Amine - Primary amine - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
External Descriptors Not available

Associated Targets(Human)

OPRM1 Tclin Mu-type opioid receptor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TACR1 Tclin Neurokinin 1 receptor (6273 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Caco-2 (12174 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MIA PaCa-2 (5949 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Opioid receptors; mu & delta (1530 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CNR2 Tchem Cannabinoid receptor (238 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UMSCC1 (87 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Cavia porcellus (23802 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
N2a (708 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRM1 Mu-opioid receptor (26 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Brain (1 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ileum (29 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Vas deferens (9 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GCGR Uncharacterized protein (2 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRK1 Opioid receptor (mu and kappa) (192 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488195306
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488195306
IUPAC Name (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
INCHI InChI=1S/C32H37N5O5/c33-25(18-23-13-15-24(38)16-14-23)32(42)37-17-7-12-28(37)31(41)36-27(20-22-10-5-2-6-11-22)30(40)35-26(29(34)39)19-21-8-3-1-4-9-21/h1-6,8-11,13-16,25-28,38H,7,12,17-20,33H2,(H2,34,39)(H,35,40)(H,36,41)/t25-,26-,27-,28-/m0/s1
InChIKey XIJHWXXXIMEHKW-LJWNLINESA-N
Smiles C1CC(N(C1)C(=O)C(CC2=CC=C(C=C2)O)N)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CC=CC=C4)C(=O)N
Isomeric SMILES C1C[C@H](N(C1)C(=O)[C@H](CC2=CC=C(C=C2)O)N)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N
WGK Germany 3
Molecular Weight 571.67(free base basis)
Reaxy-Rn 25990884
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25990884&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot Number Certificate Type Date Item
C2328449 Certificate of Analysis Jan 04, 2023 E118809
C2328445 Certificate of Analysis Jan 04, 2023 E118809
C2328460 Certificate of Analysis Jan 04, 2023 E118809
C2328476 Certificate of Analysis Jan 04, 2023 E118809
C2328431 Certificate of Analysis Jan 04, 2023 E118809
C2328440 Certificate of Analysis Jan 04, 2023 E118809
C2328441 Certificate of Analysis Jan 04, 2023 E118809
C2328432 Certificate of Analysis Jan 04, 2023 E118809
C2328453 Certificate of Analysis Jan 04, 2023 E118809
C2328433 Certificate of Analysis Jan 04, 2023 E118809
F2518028 Certificate of Analysis Jan 04, 2023 E118809

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Chemical and Physical Properties

Sensitivity Moisture sensitive
Molecular Weight 571.700 g/mol
XLogP3 2.300
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 12
Exact Mass 571.279 Da
Monoisotopic Mass 571.279 Da
Topological Polar Surface Area 168.000 Ų
Heavy Atom Count 42
Formal Charge 0
Complexity 911.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 4
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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