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Enapotamab vedotin (anti-Axl) - Primary antibody, specific to AXL, >90% (SDS-PAGE&SEC), high purity, Human IgG1, INHIBITOR of Tubulin inhibitor, INHIBITOR of Tubulin inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: MC-VC-PAB-MMAE
In stock
Item Number
Ab183333
Grouped product items
SKU Size
Availability
Price Qty
Ab183333-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$189.90
Ab183333-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$919.90
Ab183333-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,299.90
Ab183333-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$3,679.90

Purity>90% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Conjugated (MC-VC-PAB-MMAE)

Basic Description

Product Name Enapotamab vedotin (anti-Axl) - Primary antibody, specific to AXL, >90% (SDS-PAGE&SEC), high purity, Human IgG1, INHIBITOR of Tubulin inhibitor
Synonyms Adhesion related kinase antibody | AI323647 antibody | Ark antibody | Axl antibody | AXL oncogene antibody | AXL receptor tyrosine kinase antibody | AXL transforming gene antibody | AXL transforming sequence/gene antibody | EC 2.7.10.1 antibody | JTK11 an
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity AXL
Conjugation MC-VC-PAB-MMAE
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Tubulin inhibitor
Product Description

Enapotamab vedotin (anti-Axl) is an AXL-specific human IgG1 antibody conjugated to the microtubule disrupting agent monomethyl auristatin E (MMAE) through a protease cleavable valine-citrulline (vc) linker.
Purity
>90% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 150.63 kDa
Purification Method Protein A purified
Purity >90% (SDS-PAGE&SEC)
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1912424-97-5

Associated Targets(Human)

AXL Tchem Tyrosine-protein kinase receptor UFO (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
AXL Tchem Tyrosine-protein kinase receptor UFO (3469 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AXL Tchem TEL/AXL (11 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Enapotamab vedotin (anti-Axl) (Ab183333) - Flow Cytometry
Flow Cytometry analysis of HeLa cells labelling Axl (red) with Enapotamab vedotin (anti-Axl) (Ab183333) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Enapotamab vedotin (anti-Axl) (Ab183333) - Flow Cytometry
Flow Cytometry analysis of U-2 OS cells labelling Axl (red) with Enapotamab vedotin (anti-Axl) (Ab183333) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Enapotamab vedotin (anti-Axl) (Ab183333) - ELISA
Immobilized Recombinant Human Axl protein (rp183600) at 1.0 μg/mL can bind Enapotamab vedotin (anti-Axl) (Ab183333) with the EC₅₀ of 28.23 ng/mL.

Enapotamab vedotin (anti-Axl) (Ab183333) - SEC
The purity of Enapotamab vedotin (anti-Axl) (Ab183333) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

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