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Empagliflozin (BI 10773) - ≥99%, high purity , Sodium/glucose cotransporter 2 inhibitor, CAS No.864070-44-0, Sodium/glucose cotransporter 2 inhibitor

COA COA
In stock
Item Number
E127439
Grouped product items
SKU Size
Availability
 Price Qty
E127439-5mg
5mg
3
$48.90
E127439-250mg
250mg
2
$332.90
E127439-1g
1g
3
$444.90
E127439-5g
5g
3
$1,236.90
E127439-25g
25g
3
$5,566.90
E127439-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$20,039.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
Membrane Transporter (607) Membrane Transporter/Ion Channel (1822) SGLT (27) Sodium/glucose cotransporter 1 Inhibitor (14) Sodium/glucose cotransporter 2 Inhibitor (12)

Basic Description

Synonyms Empagliflozinum | GTPL4754 | NSC71966 | A852380 | s8022 | C23H27ClO7 | DTXSID601026093 | Empagliflozin [USAN:INN] | SW219120-1 | AMY1858 | HB4638 | AC-27643 | EMPAGLIFLOZIN [MI] | AKOS015999175 | BI-10773;Empagliflozin | D-Glucitol, 1,5-anhydro-1-C-(4-chl
Specifications & Purity Moligand™, ≥99%
Biochemical and Physiological Mechanisms

Empagliflozin is a potent, selective sodium glucose co-transporter-2 inhibitor that is in development for the treatment of type 2 diabetes. Empagliflozin is an inhibitor of the sodium glucose co-transporter-2 (SGLT-2), which is found almo

Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Sodium/glucose cotransporter 2 inhibitor
Product Description

Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. Phase 3.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic oxygen compounds
Class Organooxygen compounds
Subclass Carbohydrates and carbohydrate conjugates
Intermediate Tree Nodes Glycosyl compounds
Direct Parent Phenolic glycosides
Alternative Parents Diphenylmethanes  C-glycosyl compounds  Phenoxy compounds  Phenol ethers  Alkyl aryl ethers  Chlorobenzenes  Aryl chlorides  Oxanes  Monosaccharides  Tetrahydrofurans  Secondary alcohols  Polyols  Oxacyclic compounds  Dialkyl ethers  Organochlorides  Primary alcohols  Hydrocarbon derivatives  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Phenolic glycoside - Diphenylmethane - C-glycosyl compound - Phenoxy compound - Phenol ether - Alkyl aryl ether - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Benzenoid - Monocyclic benzene moiety - Oxane - Monosaccharide - Tetrahydrofuran - Secondary alcohol - Ether - Dialkyl ether - Polyol - Organoheterocyclic compound - Oxacycle - Organochloride - Primary alcohol - Alcohol - Hydrocarbon derivative - Organohalogen compound - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as phenolic glycosides. These are organic compounds containing a phenolic structure attached to a glycosyl moiety. Some examples of phenolic structures include lignans, and flavonoids. Among the sugar units found in natural glycosides are D-glucose, L-Fructose, and L rhamnose.
External Descriptors aromatic ether - monochlorobenzenes - C-glycosyl compound - tetrahydrofuryl ether

Product Properties

ALogP 2

Associated Targets(Human)

SLC5A2 Tclin Sodium/glucose cotransporter 2 (5 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SLC5A1 Tclin Sodium/glucose cotransporter 1 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
F2 Tclin Thrombin (11687 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC18A2 Tclin Synaptic vesicular amine transporter (118 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SCN5A Tclin Sodium channel protein type V alpha subunit (3462 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ABCB11 Tchem Bile salt export pump (2311 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slc5a1 Sodium/glucose cotransporter 1 (11 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slc5a2 Sodium/glucose cotransporter 2 (17 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488197794
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488197794
IUPAC Name (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
INCHI InChI=1S/C23H27ClO7/c24-18-6-3-14(23-22(28)21(27)20(26)19(11-25)31-23)10-15(18)9-13-1-4-16(5-2-13)30-17-7-8-29-12-17/h1-6,10,17,19-23,25-28H,7-9,11-12H2/t17-,19+,20+,21-,22+,23-/m0/s1
InChIKey OBWASQILIWPZMG-QZMOQZSNSA-N
Smiles C1COCC1OC2=CC=C(C=C2)CC3=C(C=CC(=C3)C4C(C(C(C(O4)CO)O)O)O)Cl
Isomeric SMILES C1COC[C@H]1OC2=CC=C(C=C2)CC3=C(C=CC(=C3)[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)Cl
Alternate CAS 864070-44-0
MeSH Entry Terms 1-chloro-4-(glucopyranos-1-yl)-2-(4-(tetrahydrofuran-3-yloxy)benzyl)benzene;BI 10773;BI-10773;BI10773;empagliflozin;Jardiance
Molecular Weight 450.91
Reaxy-Rn 31635249
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31635249&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

16 results found

Lot Number Certificate Type Date Item
B2311534 Certificate of Analysis Nov 18, 2024 E127439
B2311651 Certificate of Analysis Nov 18, 2024 E127439
B2311713 Certificate of Analysis Nov 06, 2024 E127439
B2311650 Certificate of Analysis Nov 06, 2024 E127439
B2311694 Certificate of Analysis Nov 06, 2024 E127439
B2311692 Certificate of Analysis Nov 06, 2024 E127439
H2103241 Certificate of Analysis May 11, 2023 E127439
H2103432 Certificate of Analysis May 11, 2023 E127439
H2103431 Certificate of Analysis May 11, 2023 E127439
H2103430 Certificate of Analysis May 11, 2023 E127439
D2412099 Certificate of Analysis Jan 11, 2023 E127439
D2409038 Certificate of Analysis Jan 11, 2023 E127439
G1502202 Certificate of Analysis Jan 09, 2023 E127439
L2011098 Certificate of Analysis Oct 14, 2022 E127439
L2011097 Certificate of Analysis Oct 14, 2022 E127439
C2226640 Certificate of Analysis May 23, 2022 E127439

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Chemical and Physical Properties

Solubility DMSO 90 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Molecular Weight 450.900 g/mol
XLogP3 2.000
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 6
Exact Mass 450.145 Da
Monoisotopic Mass 450.145 Da
Topological Polar Surface Area 109.000 Ų
Heavy Atom Count 31
Formal Charge 0
Complexity 558.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 6
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

  1. Empagliflozin (BI 10773), Sodium/glucose cotransporter 2 inhibitor
    Empagliflozin (BI 10773), Sodium/glucose cotransporter 2 inhibitor

    Starting at $196.90

Solution Calculators

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