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Elubrixin - 98%, high purity , Interleukin-8 receptor B antagonist, CAS No.688763-64-6, Interleukin-8 receptor B antagonist

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Elubrixin - 98%, high purity , Interleukin-8 receptor B antagonist, CAS No.688763-64-6, Interleukin-8 receptor B antagonist

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 688763-64-6
Molecular Weight: 463.31
EC Number: 629-900-7
PubChem CID: 10479502

In stock

Item Number

E610106

Grouped product items
SKU	Size	Availability	Price
E610106-1mg	1mg	3	$69.90
E610106-5mg	5mg	3	$219.90
E610106-10mg	10mg	3	$344.90
E610106-25mg	25mg	2	$689.90
E610106-50mg	50mg	1	$1,099.90
E610106-100mg	100mg	1	$1,766.90

View related series

Class A GPCR (4138) CXCR-Interleukin Related (1) CXCR2 Antagonist (8) Immunology/Inflammation (1929)

Basic Description

Synonyms	1-(4-chloro-2-hydroxy-3-(piperazin-1-ylsulfonyl)phenyl)-3-(2-chloro-3-fluorophenyl)urea \| SB-656933
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Interleukin-8 receptor B antagonist
Product Description	Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM).

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Benzenesulfonamides

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Benzenesulfonamides
Intermediate Tree Nodes	Not available
Direct Parent	Benzenesulfonamides
Alternative Parents	N-phenylureas Benzenesulfonyl compounds M-chlorophenols 1-hydroxy-4-unsubstituted benzenoids Fluorobenzenes Chlorobenzenes Piperazines Organosulfonamides Aryl chlorides Aryl fluorides Sulfonyls Ureas Azacyclic compounds Dialkylamines Carbonyl compounds Hydrocarbon derivatives Organic oxides Organochlorides Organofluorides
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Benzenesulfonamide - N-phenylurea - Benzenesulfonyl group - 3-halophenol - 3-chlorophenol - 1-hydroxy-4-unsubstituted benzenoid - Chlorobenzene - Fluorobenzene - Halobenzene - Phenol - Aryl chloride - Aryl fluoride - Aryl halide - 1,4-diazinane - Organosulfonic acid amide - Piperazine - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Urea - Azacycle - Secondary aliphatic amine - Organoheterocyclic compound - Secondary amine - Organosulfur compound - Amine - Organic nitrogen compound - Organohalogen compound - Organochloride - Organofluoride - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organonitrogen compound - Organooxygen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	2.5

Associated Targets(Human)

CXCR2 Tchem C-X-C chemokine receptor type 2 (2 Activities)

Discover Target: CXCR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CXCR2 Tchem Interleukin-8 receptor B (3491 Activities)

Discover Target: CXCR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CXCR1 Tchem Interleukin-8 receptor A (2256 Activities)

Discover Target: CXCR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1-(2-chloro-3-fluorophenyl)-3-(4-chloro-2-hydroxy-3-piperazin-1-ylsulfonylphenyl)urea
INCHI	InChI=1S/C17H17Cl2FN4O4S/c18-10-4-5-13(23-17(26)22-12-3-1-2-11(20)14(12)19)15(25)16(10)29(27,28)24-8-6-21-7-9-24/h1-5,21,25H,6-9H2,(H2,22,23,26)
InChIKey	YQYFEGTYCUQBEI-UHFFFAOYSA-N
Smiles	C1CN(CCN1)S(=O)(=O)C2=C(C=CC(=C2O)NC(=O)NC3=C(C(=CC=C3)F)Cl)Cl
Isomeric SMILES	C1CN(CCN1)S(=O)(=O)C2=C(C=CC(=C2O)NC(=O)NC3=C(C(=CC=C3)F)Cl)Cl
Alternate CAS	688763-64-6
PubChem CID	10479502
MeSH Entry Terms	SB 656933;SB-656933;SB656933
Molecular Weight	463.31

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number	Certificate Type	Date	Item
H2429186	Certificate of Analysis	May 22, 2024	E610106
H2429185	Certificate of Analysis	May 22, 2024	E610106
H2429187	Certificate of Analysis	May 22, 2024	E610106
H2429191	Certificate of Analysis	May 22, 2024	E610106
H2429188	Certificate of Analysis	May 22, 2024	E610106
H2429189	Certificate of Analysis	May 22, 2024	E610106
H2429190	Certificate of Analysis	May 22, 2024	E610106
H2429192	Certificate of Analysis	May 22, 2024	E610106
H2429193	Certificate of Analysis	May 22, 2024	E610106
H2429194	Certificate of Analysis	May 22, 2024	E610106
H2429195	Certificate of Analysis	May 22, 2024	E610106
H2429196	Certificate of Analysis	May 22, 2024	E610106

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Chemical and Physical Properties

Molecular Weight	463.300 g/mol
XLogP3	2.500
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	462.033 Da
Monoisotopic Mass	462.033 Da
Topological Polar Surface Area	119.000 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	677.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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