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Elimusertib hydrochloride - 98%, high purity , CAS No.1876467-74-1(free base)

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 1876467-74-1(free base)

In stock

Item Number

E414104

Grouped product items
SKU	Size	Availability	Price
E414104-2mg	2mg	2	$181.90
E414104-5mg	5mg	2	$343.90
E414104-10mg	10mg	2	$583.90
E414104-25mg	25mg	2	$1,029.90
E414104-50mg	50mg	2	$1,716.90
E414104-100mg	100mg	2	$2,952.90

ATR Selective Inhibitors

View related series

DNA Damage (697)

Basic Description

Synonyms	BAY 1895344 hydrochloride \| BAY-1895344 HCl \| 2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-1,7-Naphthyridine hydrochloride
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Product Description	Information Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally availableATRinhibitor with an IC50 of 7 nM. Targets ATR (Cell-free assay) 7 nM In vitro BAY 1895344 is shown to be a very potent and highly selective ATR inhibitor (IC50 = 7 nM), which potently inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 = 78 nM). In cellular mechanistic assays BAY 1895344 potently inhibits hydroxyurea-induced H2AX phosphorylation (IC50 = 36 nM). In vivo BAY 1895344 reveals significantly improved aqueous solubility, bioavailability across species and no activity in the hERG patch-clamp assay. It also demonstrates very promising efficacy in monotherapy in DNA damage deficient tumor models as well as combination treatment with DNA damage inducing therapies. BAY 1895344 exhibits strong in vivo anti-tumor efficacy in monotherapy in a variety of xenograft models of different indications that are characterized by DDR deficiencies, inducing stable disease in ovarian and colorectal cancer or even complete tumor remission in mantle cell lymphoma models.

Associated Targets(Human)

ATR Tchem Serine/threonine-protein kinase ATR (1 Activities)

Discover Target: ATR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MTOR Tclin Serine/threonine-protein kinase mTOR (1 Activities)

Discover Target: MTOR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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7 results found

Lot Number	Certificate Type	Date	Item
F2524409	Certificate of Analysis	Jun 26, 2025	E414104
K2229688	Certificate of Analysis	Oct 19, 2022	E414104
K2229741	Certificate of Analysis	Oct 19, 2022	E414104
K2229742	Certificate of Analysis	Oct 19, 2022	E414104
K2229747	Certificate of Analysis	Oct 19, 2022	E414104
K2229745	Certificate of Analysis	Oct 19, 2022	E414104
K2229640	Certificate of Analysis	Oct 19, 2022	E414104

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 82 mg/mL (199.08 mM); Water: 82 mg/mL (199.08 mM); Ethanol: 82 mg/mL (199.08 mM);
Sensitivity	Moisture sensitive

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