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Elacridar - 10mM in DMSO, high purity , CAS No.143664-11-3
Basic Description
Synonyms
Elacridar | 143664-11-3 | GF120918 | Elacridar [INN] | GF-120918 | GG918 | N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide | Elacridar (GF120918) | GF 120918 | CHEMBL396298 | N-(4-(2-(6,7-dimethoxy-3,4-dihydrois
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
A prototypical BCRP (ABCG2) and MDR-1 inhibitor which inhibits the Bcrp1-mediated transport. It increases the availablity of cytotoxic antitumor drugs. Allows the uptake of more anti-HIV drugs in the brain and CNS.
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description
Elacridar (GF120918; GW0918) is a P-glycoprotein inhibitor and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules.
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Organoheterocyclic compounds
Class
Quinolines and derivatives
Subclass
Benzoquinolines
Intermediate Tree Nodes
Acridines
Direct Parent
Acridones
Alternative Parents
Aromatic anilides Quinoline carboxamides Hydroquinolones Hydroquinolines Tetrahydroisoquinolines Phenethylamines Anisoles Alkyl aryl ethers Aralkylamines Pyridines and derivatives Heteroaromatic compounds Vinylogous amides Secondary carboxylic acid amides Trialkylamines Amino acids and derivatives Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework
Aromatic heteropolycyclic compounds
Substituents
Acridone - Aromatic anilide - Quinoline-8-carboxamide - Dihydroquinolone - Dihydroquinoline - Tetrahydroisoquinoline - Phenethylamine - Anisole - Alkyl aryl ether - Aralkylamine - Monocyclic benzene moiety - Pyridine - Benzenoid - Heteroaromatic compound - Vinylogous amide - Tertiary aliphatic amine - Amino acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Tertiary amine - Azacycle - Carboxylic acid derivative - Ether - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Amine - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description
This compound belongs to the class of organic compounds known as acridones. These are acridines containing a ketone group attached to the C9 carbon atom of the acridine moiety.
External Descriptors
Not available
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
IUPAC Name
N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide
INCHI
InChI=1S/C34H33N3O5/c1-40-28-9-5-7-26-32(28)36-31-25(33(26)38)6-4-8-27(31)34(39)35-24-12-10-21(11-13-24)14-16-37-17-15-22-18-29(41-2)30(42-3)19-23(22)20-37/h4-13,18-19H,14-17,20H2,1-3H3,(H,35,39)(H,36,38)
InChIKey
OSFCMRGOZNQUSW-UHFFFAOYSA-N
Smiles
COC1=CC=CC2=C1NC3=C(C2=O)C=CC=C3C(=O)NC4=CC=C(C=C4)CCN5CCC6=CC(=C(C=C6C5)OC)OC
Isomeric SMILES
COC1=CC=CC2=C1NC3=C(C2=O)C=CC=C3C(=O)NC4=CC=C(C=C4)CCN5CCC6=CC(=C(C=C6C5)OC)OC
WGK Germany
3
RTECS
AR7621300
Molecular Weight
563.64
Reaxy-Rn
7324887
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7324887&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Sensitivity
Heat Sensitive
Melt Point(°C)
210 °C
Molecular Weight
563.600 g/mol
XLogP3
5.600
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Rotatable Bond Count
8
Exact Mass
563.242 Da
Monoisotopic Mass
563.242 Da
Topological Polar Surface Area
89.100 Ų
Heavy Atom Count
42
Formal Charge
0
Complexity
925.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
1
Citations of This Product
1.
Jieyu Zhang, Yan Chen, Wenxiang Fan, Linnan Li, Yueming Ma, Zhengtao Wang, Rong Shi, Li Yang.
(2023)
Study on herb-herb interaction between active components of Plantago asiatica L. seed and Coptis chinensis Franch. rhizoma based on transporters using UHPLC-MS/MS. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,
227
(115234).
2.
Qiurui Li, Hua Lin, Yanfen Niu, Yan Liu, Zhenyu Wang, Liudong Song, Lihui Gao, Ling Li.
(2020)
Mangiferin promotes intestinal elimination of uric acid by modulating intestinal transporters. EUROPEAN JOURNAL OF PHARMACOLOGY,
888
(173490).
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2 Citations