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E. coli heat-stable enterotoxin (STa), TFA salt, Agonist of Guanylyl cyclase-C, CAS No.118447-40-8(free base), Agonist of Guanylyl cyclase-C

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Item Number
rp174249
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rp174249-1mg
1mg
Available within 8-12 weeks(?)
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$229.90
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Guanylyl cyclase-C Agonist (5)

Basic Description

Product Name E. coli heat-stable enterotoxin (STa), TFA salt, Agonist of Guanylyl cyclase-C, CAS No.118447-40-8(free base)
Synonyms STh
Grade Moligand™
Product Description

STh, an Escherichia coli heat-stable toxin, is a 19 amino acid polypeptide encompassing three disulfide bridges. STh is an antigen of interest in the search for a broad coverage enterotoxigenic Escherichia coli (ETEC) vaccine.

Specifications & Purity Moligand™, ≥95%(HPLC)
Sequence NSSNYCCELCCNPACTGCY (Disulfide bridge:Cys6-11;Cys7-15;Cys10-18)
Action Type AGONIST
Mechanism of action Agonist of Guanylyl cyclase-C

Associated Targets(Human)

GUCY2C Tclin Heat-stable enterotoxin receptor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Storage and Shipping

Storage Temp Protected from light,Store at -20°C,Argon charged,Desiccated,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -20 ℃. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. Sealed storage, away from moisture. Protect from light.
CAS 118447-40-8(free base)

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Genetic information

Alternate Names STh
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

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