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Dynarrestin - ≥98%(HPLC), high purity , CAS No.2222768-84-3

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 2222768-84-3
Molecular Weight: 431.5
PubChem CID: 137919864
PubChem SID: 504773517

In stock

Item Number

D286946

Grouped product items
SKU	Size	Availability	Price
D286946-5mg	5mg	3	$107.90
D286946-10mg	10mg	3	$184.90
D286946-25mg	25mg	3	$416.90
D286946-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$489.90
D286946-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$882.90

Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein

View related series

Hedgehog (25) Stem Cell/Wnt (1019)

Basic Description

Synonyms	Ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiazole-5-carboxylate \| 4-(4-Diethylaminophenyl)-2-(2,4-difluoro-phenylamino)-thiazole-5-carboxylic acid ethyl ester
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Dynein inhibitor. Inhibits hedgehog signalingin vitro(IC50= 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

Pubchem Sid	504773517
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504773517
IUPAC Name	ethyl 4-[4-(diethylamino)phenyl]-2-(2,4-difluoroanilino)-1,3-thiazole-5-carboxylate
INCHI	InChI=1S/C22H23F2N3O2S/c1-4-27(5-2)16-10-7-14(8-11-16)19-20(21(28)29-6-3)30-22(26-19)25-18-12-9-15(23)13-17(18)24/h7-13H,4-6H2,1-3H3,(H,25,26)
InChIKey	UZNNDDDSGCMQOQ-UHFFFAOYSA-N
Smiles	CCN(CC)C1=CC=C(C=C1)C2=C(SC(=N2)NC3=C(C=C(C=C3)F)F)C(=O)OCC
Molecular Weight	431.5
Reaxy-Rn	32644520
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32644520&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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6 results found

Lot Number	Certificate Type	Date	Item
C2506067	Certificate of Analysis	Sep 26, 2022	D286946
B2309501	Certificate of Analysis	Sep 26, 2022	D286946
B2309887	Certificate of Analysis	Sep 26, 2022	D286946
B23091299	Certificate of Analysis	Sep 26, 2022	D286946
B2309989	Certificate of Analysis	Sep 26, 2022	D286946
B23091252	Certificate of Analysis	Sep 26, 2022	D286946

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 43.15, Max Conc. mM: 100
Sensitivity	Light sensitive
Molecular Weight	431.500 g/mol
XLogP3	6.100
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	9
Exact Mass	431.148 Da
Monoisotopic Mass	431.148 Da
Topological Polar Surface Area	82.700 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	546.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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