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DY131 - ≥98%, high purity , CAS No.95167-41-2, Agonist of Estrogen-related receptor-β;Agonist of Estrogen-related receptor-γ

COA COA
In stock
Item Number
D126355
Grouped product items
SKU Size
Availability
 Price Qty
D126355-10mg
10mg
3
$98.90
D126355-50mg
50mg
3
$345.90
D126355-250mg
250mg
2
$1,557.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Agonist selective for estrogen-related receptors ERRβ and ERRγ

View related series
Estrogen Receptor/ERR (213) Estrogen-related receptor-β Agonist (4) Estrogen-related receptor-γ Agonist (8) Smo (39) Stem Cell/Wnt (1019) Vitamin D Related/Nuclear Receptor (907)

Basic Description

Synonyms DTXSID00176875 | EN300-1700019 | N'-((1E)-(4-(diethylamino)phenyl)methylene)-4-hydroxybenzohydrazide | DY131 | N'-{[4-(diethylamino)phenyl]methylidene}-4-hydroxybenzohydrazide | Aminotris(methylenephoshonic acid) pentasodium salt | Z49615781 | AC-35431 |
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms Novel selective agonist at estrogen-related receptors ERRβand ERRγ. Displays minimal activity at ERRα, ERαand ERβat concentrations up to 30μM.
Storage Temp Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type AGONIST
Mechanism of action Agonist of Estrogen-related receptor-β;Agonist of Estrogen-related receptor-γ
Product Description

DY131(GSK 9089) is a novel selective agonist of ERRβ and ERRγ; displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM.
A novel selective agonist at ERRβ and ERRγ

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Benzoic acids and derivatives
Intermediate Tree Nodes Not available
Direct Parent Benzoic acids and derivatives
Alternative Parents Dialkylarylamines  Benzoyl derivatives  Aniline and substituted anilines  1-hydroxy-2-unsubstituted benzenoids  Amino acids and derivatives  Organopnictogen compounds  Organooxygen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic homomonocyclic compounds
Substituents Benzoic acid or derivatives - Benzoyl - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Aniline or substituted anilines - Phenol - 1-hydroxy-2-unsubstituted benzenoid - Tertiary amine - Amino acid or derivatives - Carboxylic acid derivative - Hydrocarbon derivative - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Amine - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as benzoic acids and derivatives. These are organic compounds containing a carboxylic acid substituent attached to a benzene ring.
External Descriptors Not available

Associated Targets(Human)

ESRRB Tchem Steroid hormone receptor ERR2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ESRRG Tchem Estrogen-related receptor gamma (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ESRRG Tchem Estrogen-related receptor gamma (587 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CASP1 Tchem Caspase-1 (6235 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504763898
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504763898
IUPAC Name N-[(E)-[4-(diethylamino)phenyl]methylideneamino]-4-hydroxybenzamide
INCHI InChI=1S/C18H21N3O2/c1-3-21(4-2)16-9-5-14(6-10-16)13-19-20-18(23)15-7-11-17(22)12-8-15/h5-13,22H,3-4H2,1-2H3,(H,20,23)/b19-13+
InChIKey WLKOCYWYAWBGKY-CPNJWEJPSA-N
Smiles CCN(CC)C1=CC=C(C=C1)C=NNC(=O)C2=CC=C(C=C2)O
Isomeric SMILES CCN(CC)C1=CC=C(C=C1)/C=N/NC(=O)C2=CC=C(C=C2)O
Molecular Weight 311.38
Reaxy-Rn 2765110
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2765110&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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Lot Number Certificate Type Date Item
D1727042 Certificate of Analysis Nov 16, 2022 D126355

Chemical and Physical Properties

Solubility Solvent:ethanol, Max Conc. mg/mL: 3.11, Max Conc. mM: 10; Solvent:DMSO, Max Conc. mg/mL: 31.14, Max Conc. mM: 100
Refractive Index 1.57
Molecular Weight 311.400 g/mol
XLogP3 3.100
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 6
Exact Mass 311.163 Da
Monoisotopic Mass 311.163 Da
Topological Polar Surface Area 64.900 Ų
Heavy Atom Count 23
Formal Charge 0
Complexity 380.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 1
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 1
Covalently-Bonded Unit Count 1

Solution Calculators

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