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DY 268 - ≥98%(HPLC), high purity , CAS No.1609564-75-1

COA COA
    Grade & Purity:
  • ≥98%(HPLC)
In stock
Item Number
D288547
Grouped product items
SKU Size
Availability
 Price Qty
D288547-5mg
5mg
6
$98.90
D288547-10mg
10mg
5
$157.90
D288547-25mg
25mg
3
$355.90
D288547-50mg
50mg
3
$573.90
D288547-100mg
100mg
3
$939.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Potent FXR antagonist

View related series
FXR (37) Lipid metabolism (1912) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms 1-[(3-Methoxyphenyl)methyl]-N-[4-methyl-3-(4-morpholinylsulfonyl)phenyl]-3-(4-methylphenyl)-1H-pyrazole-4-carboxamide
Specifications & Purity ≥98%(HPLC)
Biochemical and Physiological Mechanisms Potent FXR antagonist (IC50= 7.5 nM). Exhibits no detectable cytotoxicity in cell-based assays.
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Product description

DY268 is a farnesoid X receptor (FXR) antagonist (IC50=7.5 nM in a time-resolved FRET assay). It inhibits FXR transactivation in a cell-based assay with an IC50 value of 468 nM.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Anilides
Intermediate Tree Nodes Not available
Direct Parent Aromatic anilides
Alternative Parents Phenylpyrazoles  Benzenesulfonamides  Benzenesulfonyl compounds  Pyrazole-4-carboxamides  Phenoxy compounds  Anisoles  Methoxybenzenes  Toluenes  Alkyl aryl ethers  Organosulfonamides  Morpholines  Vinylogous amides  Sulfonyls  Heteroaromatic compounds  Secondary carboxylic acid amides  Oxacyclic compounds  Azacyclic compounds  Dialkyl ethers  Organic oxides  Hydrocarbon derivatives  Organonitrogen compounds  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents Aromatic anilide - Phenylpyrazole - Benzenesulfonamide - Benzenesulfonyl group - Phenoxy compound - Anisole - Pyrazole-4-carboxamide - Phenol ether - Methoxybenzene - Alkyl aryl ether - Toluene - Morpholine - Oxazinane - Organosulfonic acid amide - Azole - Heteroaromatic compound - Pyrazole - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Sulfonyl - Vinylogous amide - Secondary carboxylic acid amide - Carboxamide group - Azacycle - Oxacycle - Ether - Dialkyl ether - Organoheterocyclic compound - Carboxylic acid derivative - Organic oxygen compound - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic nitrogen compound - Organic oxide - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as aromatic anilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with an aromatic group. They have the general structure RNC(=O)R', where R= benzene, and R = aryl group.
External Descriptors Not available

Associated Targets(Human)

NR1H4 Tclin Bile acid receptor (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CSNK1D Tchem Casein kinase I delta (4546 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NR1H4 Tclin Bile acid receptor FXR (6228 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U2OS (164939 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TRIM24 Tchem Transcription intermediary factor 1-alpha (2087 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BRPF1 Tchem Peregrin (2217 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Mapk1 MAP kinase ERK2 (650 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488202506
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488202506
IUPAC Name 1-[(3-methoxyphenyl)methyl]-N-(4-methyl-3-morpholin-4-ylsulfonylphenyl)-3-(4-methylphenyl)pyrazole-4-carboxamide
INCHI InChI=1S/C30H32N4O5S/c1-21-7-10-24(11-8-21)29-27(20-33(32-29)19-23-5-4-6-26(17-23)38-3)30(35)31-25-12-9-22(2)28(18-25)40(36,37)34-13-15-39-16-14-34/h4-12,17-18,20H,13-16,19H2,1-3H3,(H,31,35)
InChIKey KQSPAAPFKIEUGH-UHFFFAOYSA-N
Smiles CC1=CC=C(C=C1)C2=NN(C=C2C(=O)NC3=CC(=C(C=C3)C)S(=O)(=O)N4CCOCC4)CC5=CC(=CC=C5)OC
Isomeric SMILES CC1=CC=C(C=C1)C2=NN(C=C2C(=O)NC3=CC(=C(C=C3)C)S(=O)(=O)N4CCOCC4)CC5=CC(=CC=C5)OC
Molecular Weight 560.66
Reaxy-Rn 26849841
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26849841&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number Certificate Type Date Item
D2326250 Certificate of Analysis Mar 30, 2023 D288547
D2326251 Certificate of Analysis Mar 30, 2023 D288547
D2326265 Certificate of Analysis Mar 30, 2023 D288547
D2326258 Certificate of Analysis Mar 30, 2023 D288547
D2326290 Certificate of Analysis Mar 30, 2023 D288547
D2326270 Certificate of Analysis Mar 30, 2023 D288547
D2326269 Certificate of Analysis Mar 30, 2023 D288547
D2326259 Certificate of Analysis Mar 30, 2023 D288547
D2326255 Certificate of Analysis Mar 30, 2023 D288547
D2326520 Certificate of Analysis Mar 30, 2023 D288547

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 56.07, Max Conc. mM: 100
Molecular Weight 560.700 g/mol
XLogP3 3.800
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 8
Exact Mass 560.209 Da
Monoisotopic Mass 560.209 Da
Topological Polar Surface Area 111.000 Ų
Heavy Atom Count 40
Formal Charge 0
Complexity 931.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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