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Doxercalciferol - 98%, high purity , Vitamin D receptor agonist, CAS No.54573-75-0, Vitamin D receptor agonist

COA COA
In stock
Item Number
D120130
Grouped product items
SKU Size
Availability
 Price Qty
D120130-1mg
1mg
3
$24.90
D120130-5mg
5mg
3
$103.90
D120130-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$351.90
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Bulk Order  SDS  DATASHEET  Specification Sheet

Vitamin D2analog, VDR agonist

View related series
VD/VDR (83) Vitamin D receptor Agonist (16) Vitamin D Related/Nuclear Receptor (907)

Basic Description

Synonyms 1-Hydroxyergocalciferol | 1.alpha.-Hydroxyvitamin D2 | AKOS005146517 | DOXERCALCIFEROL [USAN] | DOXERCALCIFEROL [VANDF] | TSA-840 | D82103 | GTPL2790 | 1alpha-hydroxyvitamin D2 / 1alpha-hydroxyergocalciferol | BRN 4716774 | H05BX03 | (1R,3S,5Z)-5-[(2E)-2-
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms Vitamin D2analog that acts as a vitamin D receptor activator (VDRA).
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type AGONIST
Mechanism of action Vitamin D receptor agonist

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Lipids and lipid-like molecules
Class Steroids and steroid derivatives
Subclass Vitamin D and derivatives
Intermediate Tree Nodes Not available
Direct Parent Vitamin D and derivatives
Alternative Parents Triterpenoids  Secondary alcohols  Cyclic alcohols and derivatives  Hydrocarbon derivatives  
Molecular Framework Aliphatic homopolycyclic compounds
Substituents Triterpenoid - Cyclic alcohol - Secondary alcohol - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Alcohol - Aliphatic homopolycyclic compound
Description This compound belongs to the class of organic compounds known as vitamin d and derivatives. These are compounds containing a secosteroid backbone, usually secoergostane or secocholestane.
External Descriptors Vitamin D2 and derivatives

Product Properties

ALogP 6.3

Associated Targets(Human)

VDR Tclin Vitamin D3 receptor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CSNK1D Tchem Casein kinase I delta (4546 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Homo sapiens (32628 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U2OS (164939 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TRIM24 Tchem Transcription intermediary factor 1-alpha (2087 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BRPF1 Tchem Peregrin (2217 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK-293T (167025 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Mapk1 MAP kinase ERK2 (650 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504763332
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504763332
IUPAC Name (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
INCHI InChI=1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1
InChIKey HKXBNHCUPKIYDM-CGMHZMFXSA-N
Smiles CC(C)C(C)C=CC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
Isomeric SMILES C[C@H](/C=C/[C@H](C)C(C)C)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C
WGK Germany 3
PubChem CID 5281107
Molecular Weight 412.65

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
F1503057 Certificate of Analysis Feb 13, 2023 D120130
C2205470 Certificate of Analysis Mar 12, 2022 D120130
C2205463 Certificate of Analysis Mar 12, 2022 D120130

Chemical and Physical Properties

Solubility Solvent:ethanol, Max Conc. mg/mL: 20.63, Max Conc. mM: 50; Solvent:DMSO, Max Conc. mg/mL: 4.13, Max Conc. mM: 10
Sensitivity Heat Sensitive
Melt Point(°C) 140 °C
Molecular Weight 412.600 g/mol
XLogP3 6.300
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 5
Exact Mass 412.334 Da
Monoisotopic Mass 412.334 Da
Topological Polar Surface Area 40.500 Ų
Heavy Atom Count 30
Formal Charge 0
Complexity 712.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 7
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 3
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 3
Covalently-Bonded Unit Count 1

Solution Calculators

Reviews

Customer Reviews

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